Multifaceted Application of Silica Nanoparticles. A Review

Jeelani, Peerzada Gh; Mulay, Prajakta; Venkat, R Bhethanabotla; Ramalingam, C.

doi:10.1007/s12633-019-00229-y

Cited by 338 publications

(197 citation statements)

References 122 publications

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“…Also, they are easily detectable in SAXS and DLS, which are the two main methods in this study. They have a widespread usage, and are commonly studied in biological and environmental studies from 1 μg•mL -1 in biology to 200 mg•mL -1 in agriculture studies [20]. To be able to depict the early stage of NP agglomeration triggered by environmental changes, we developed a microfluidic mixing device followed by a quartz capillary allowing the investigation on the NP behavior in situ by SAXS ( Fig.…”

Section: Introductionmentioning

confidence: 99%

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

et al. 2020

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Nanoparticle (NP) colloidal stability plays a crucial role in biomedical application not only for human and environmental safety but also for NP efficiency and functionality. NP agglomeration is considered as a possible process in monodispersed NP colloidal solutions, which drastically affects colloidal stability. This process is triggered by changes in the physicochemical properties of the surrounding media, such as ionic strength (IS), pH value, or presence of biomolecules. Despite different available characterization methods for nanoparticles (NPs), there is a lack of information about the underlying mechanisms at the early stage of dynamic behaviors, namely changing in NP size distribution and structure while placing them from a stable colloidal solution to a new media like biological fluids. In this study, an advanced in situ approach is presented that combines small angle X-ray scattering (SAXS) and microfluidics, allowing label-free, direct, time-resolved, and dynamic observations of the early stage of NP interaction/agglomeration initiated by environmental changes. It is shown for silica NPs that the presence of protein in the media enormously accelerates the NP agglomeration process compared to respective changes in IS and pH. High IS results in a staring agglomeration process after 40 min, though, in case of protein presence in media, this time decreased enormously to 48 s. These time scales show that this method is sensitive and precise in depicting the dynamics of fast and slow NP interactions in colloidal conditions and therefore supports understanding the colloidal stability of NPs in various media concluding in safe and efficient NP designing for various applications.

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Section: Introductionmentioning

confidence: 99%

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

et al. 2020

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“…Indeed, with the increasing use of SiO 2 NPs, its release into the environment may occur either from localized sources, such as industrial plants or landfills, or from non-localized sources, e.g., storm-water runoffs, runoffs from soils and from the degradation of products containing these nanomaterials (for example: personal care products, plastics, rubbers, coatings and ceramics) [6]. The addition of manufactured nanosilica can change the soil mineral composition, being frequently applied in the agriculture sector to increase seed viability and germination rate, as an ingredient in pesticides/fertilizer elements and to enhance plant tolerance to abiotic stresses [7][8][9]. Hence, it is expected that soil will be an important reservoir of engineered SiO 2 nanopowders in variable states of aggregation and combination, making crucial a correct assessment of potential impacts in terrestrial environments and in the overall soil ecosystem [7].…”

Section: Introductionmentioning

confidence: 99%

“…The addition of manufactured nanosilica can change the soil mineral composition, being frequently applied in the agriculture sector to increase seed viability and germination rate, as an ingredient in pesticides/fertilizer elements and to enhance plant tolerance to abiotic stresses [7][8][9]. Hence, it is expected that soil will be an important reservoir of engineered SiO 2 nanopowders in variable states of aggregation and combination, making crucial a correct assessment of potential impacts in terrestrial environments and in the overall soil ecosystem [7]. These are important interdisciplinary approaches, namely because reported studies on engineered nanoparticles, have also shown specific abiotic properties (e.g., size, shape, surface-to-volume ratio and silanol group concentration) that modify toxic effects in organisms as compared to bulk silica powders [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Amorphous Silica Nanopowders on the Avoidance Behavior of Five Soil Species—A Screening Study

et al. 2020

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Silica nanoparticles (SiO2NPs) are one of the most used in commercial products and biomedical tools, however, their environmental effects have not been fully described. Although negative effects of SiO2NPs on the behavior of freshwater invertebrates have been reported, the knowledge is limited, especially the effect of nanopowders in terrestrial organisms. Accordingly, the aim of the present study is to understand the effects of SiO2NPs on the avoidance behavior of five soil species, whose niche may differ thus contributing to differential harmful SiO2NPs effects. Hence, avoidance assays testing SiO2NPs concentrations of 0, 10, 100, 250, 500 and 1000 mg/kg were performed with Enchytraeus crypticus, Folsomia candida, Tenebrio molitor, Porcellionides pruinosus and Eisenia fetida. SiO2NPs induced different behavioral effects, depending on the invertebrate ecology/habitat, exposure route and physiology. T. molitor, P. pruinosus and F. candida did not avoid contaminated soil; however, E. crypticus and E. fetida significantly avoided SiO2NPs spiked soil. Since these terrestrial worms (oligochaetes) live mostly burrowed in the soil, this can provide greater opportunity for SiO2NPs’ uptake. On the other hand, the other tested organisms mainly living on the upper part of the soil did not avoid the SiO2NPs spiked soil. The avoidance data obtained here also highlight the need for further studies to understand whether (or not) the detected behavioral responses are linked to either neurotransmission processes or sensorial aspects of the biological models.

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“…Silica (SiO 2 ) nanomaterials (NMs) are currently produced in large-scale and are amongst the most widely commercialised manufactured NMs. SiO 2 NMs are easily synthesized in different size, shape, crystallinity, porosity and surface chemistry enabling their use in different elds from biomedicine to cosmetics, in the food industry or for bioremediation [1,2,3]. More speci cally, amorphous silica nanomaterials (aSiO 2 NMs) are being extensively used for industrial purposes such as biosensors and catalytic supports, stabilizers of emulsions or foams in enhanced oil recovery processes, for the improvement of the mechanical characteristics of polymers and composites, and as additives for paints/lacquers/coatings [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…SiO 2 NMs are easily synthesized in different size, shape, crystallinity, porosity and surface chemistry enabling their use in different elds from biomedicine to cosmetics, in the food industry or for bioremediation [1,2,3]. More speci cally, amorphous silica nanomaterials (aSiO 2 NMs) are being extensively used for industrial purposes such as biosensors and catalytic supports, stabilizers of emulsions or foams in enhanced oil recovery processes, for the improvement of the mechanical characteristics of polymers and composites, and as additives for paints/lacquers/coatings [1,3]. This wide range of industrial applications and growing commercial production obviously increased the likelihood of human exposure to aSiO 2 NMs, mainly through inhalation [4,5].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity and Gene Expression in the Rat Lung Tissue Following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NMs)

Brandão

Costa

Bessa

et al. 2020

Preprint

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Background: Synthetic amorphous silica (SAS) has been widely used in several industrial and consumer applications for decades and considered safe for humans. However, several reports on the in vitro and in vivo toxicity of amorphous silica nanomaterials (aSiO2 NMs) have been questioning its safety at the nanoscale. In the present study, we investigated the influence of the physicochemical properties (size and surface chemistry) on in vivo pulmonary toxicity using four variants of aSiO2 NMs (SiO2_15_Unmod, SiO2_15_Amino, SiO2_7 and SiO2_40). We focused on alterations in lung DNA and protein integrity, and gene expression following intratracheal instillation in rats. Additionally, a short-term inhalation study (STIS) was carried out for SiO2_7, using TiO2_NM105 as a benchmark NM.Results: Overall, single intratracheal instillation of all tested NMs did not cause a significant increase of DNA strand breaks in the rat lung. However, a significant but slight increase of oxidative DNA damage in rats exposed to the highest instilled dose (0.36 mg/rat) of SiO2_15_ Amino was observed at 21 days post-exposure. In turn, exposure to SiO2_7 or SiO2_40 markedly increased oxidative DNA lesions in the rat lung cells in every tested dose at 3 days post-exposure, even though in a dose-independent manner. Nevertheless, this damage seems to be repaired since no changes compared to controls were observed in the recovery groups. In STIS, a significant increase of DNA strand breaks in the lung cells of rats exposed to 0.5 mg/m3 of SiO2_7 or to 50 mg/m3 of TiO2_NM105 was observed at both assessed time-points. The gene expression changes detected suggest that oxidative stress and/or inflammation pathways are likely implicated in the induction of (oxidative) DNA damage.Conclusions: Overall, all tested aSiO2 NMs were not associated with marked in vivo toxicity following instillation or STIS. Under our experimental conditions, pyrogenic aSiO2 NMs (SiO2_7 and SiO2_40) showed a higher genotoxic potential compared to colloidal aSiO2 (SiO2_15_Unmod and SiO2_15_Amino). Overall, genotoxicity findings for SiO2_7 from instillation and STIS are concordant, however changes in STIS animals were more permanent/difficult to revert.

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Multifaceted Application of Silica Nanoparticles. A Review

Cited by 338 publications

References 122 publications

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

Effects of Amorphous Silica Nanopowders on the Avoidance Behavior of Five Soil Species—A Screening Study

Genotoxicity and Gene Expression in the Rat Lung Tissue Following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NMs)

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