Multifaceted activation of STING axis upon Nipah and Measles virus-induced syncytia formation
Lucia Amurri,
Claire Dumont,
Rodolphe Pelissier
et al.
Abstract:Activation of the DNA-sensing STING axis by RNA viruses plays a role in antiviral response through mechanisms that remain poorly understood. Here, we show that the STING pathway regulates Nipah virus (NiV) replication in vivo in mice. Moreover, we demonstrate that following both NiV and measles virus (MeV) infection, IFNγ-inducible protein 16 (IFI16), an alternative DNA sensor in addition to cGAS, induces the activation of STING, leading to the phosphorylation of NF-κB p65 and the production of IFNβ and interl… Show more
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