Multienzyme‐Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy

Yang, Peipei; Tao, Jia; Chen, Fengfeng; Chen, Yuying; He, Jiaming; Shen, Kui; Zhao, Peng; Li, Yingwei

doi:10.1002/smll.202005865

Cited by 88 publications

(53 citation statements)

References 58 publications

(53 reference statements)

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“…In addition, other metal elements have also been exploited for realizing two‐metal‐ion‐based CDT. [ 371–388 ] Yang et al. designed ancient pigment nanosheets (SrCuSi 4 O 10 NSs, abbreviated as SC NSs) and functionalized them with GOx to afford SC@G NSs for the synergistic action of ST, PTT, and CDT ( Figure a).…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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287

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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287

212

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“…The results of our in vivo experiment under osteoporosis conditions are consistent with those reported in the literature. Although there may be concerns about the biosafety of MOF nanomaterials, a number of recent studies have shown that low concentrations of MOF nanomaterials have no significant biotoxicity [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation

et al. 2022

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Background Femoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this implant in patients with osteoporosis is limited due to excessive bone resorption. Macrophages participate in the regulation of inflammatory response and have been a topic of increasing research interest in implant field. However, few study has explored the link between macrophage polarization and osteogenic–osteoclastic differentiation. The present study aims to develop a novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through immunotherapy. Method To improve the osteointegration under osteoporosis, we developed a hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold (PT). Biomimetic extracellular matrix (ECM) was constructed inside the interconnected pores of PT in micro-scale. And in nano-scale, a drug cargo icariin@Mg-MOF-74 (ICA@MOF) was wrapped in ECM-like structure that can control release of icariin and Mg2+. Results In this novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold, the macroporous structure provides mechanical support, the microporous structure facilitates cell adhesion and enhances biocompatibility, and the nanostructure plays a biological effect. We also demonstrate the formation of abundant new bone at peripheral and internal sites after intramedullary implantation of the biofunctionalized PT into the distal femur in osteoporotic rats. We further find that the controlled-release of icariin and Mg2+ from the biofunctionalized PT can significantly improve the polarization of M0 macrophages to M2-type by inhibiting notch1 signaling pathway and induce the secretion of anti-inflammatory cytokines; thus, it significantly ameliorates bone metabolism, which contributes to improving the osseointegration between the PT and osteoporotic bone. Conclusion The therapeutic potential of hierarchical PT implants containing controlled release system are effective in geriatric orthopaedic osseointegration. Graphical Abstract

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“…[61][62][63] Meanwhile, due to their porous structure and excellent catalytic properties, MOFs are also widely used in CDT. [64,65] Ding et al fabricated a hybrid nanoagent (Au/FeMOF@CPT NPs) using gold nanoparticles (Au NPs) and FeMOF NPs to load camptothecin (CPT) (Figure 2C). [63] Once exposed to the excess phosphate in tumor cells, Au/FeMOF@CPT NPs would collapse to release CPT completely and activate a cascade catalytic reaction.…”

Section: Fe-based Nanocatalysts For Fenton Reactionmentioning

confidence: 99%

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Zhang

Wan

et al. 2021

Adv Healthcare Materials

126

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Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal therapy, are developed and used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton-like reaction to generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O 2 ) to kill cancer cells, which displays promising therapeutic potentials for tumor treatment. However, the low catalytic efficiency and off-target side effects of Fenton reaction limit the biomedical application of CDT. In this regard, various strategies are implemented to potentiate CDT against tumor, including retrofitting the tumor microenvironment (e.g., increasing H 2 O 2 level, decreasing reductive substances, and reducing pH), enhancing the catalytic efficiency of nanocatalysts, and other strategies. This review aims to summarize the development of CDT and summarize these recent progresses of nanocatalyst-mediated CDT for antitumor application. The future development trend and challenges of CDT are also discussed.

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Multienzyme‐Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy

Cited by 88 publications

References 58 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

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