Multielemental analysis of human thyroid glands using particle induced X-ray emission (PIXE)

Maeda, Kuniko; Yokode, Yutaka; Sasa, Y.; Kusuyama, Hiroko; Uda, M.

doi:10.1016/0168-583x(87)90323-5

Cited by 21 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mean values obtained for Br, Ca, I, and Mn contents in TBN (Table 3) agree well with median of mean values reported by other researches [56][57][58]60,61,64]. Mean mass fractions of Cl and Na in TBN obtained in present study were almost one order of magnitude and 3 times higher those in only published article on Cl [59] and Na [65].…”

Section: Differences Between Mean Values (Msem) Of Br Ca CL I K Mg M...supporting

confidence: 90%

“…Mean values obtained for Ca, I, Mg, and Mn contents in TMN (Table 3) agree well with median of mean values reported by other researches [56,59,62,66,[68][69][70]. Mean mass fraction obtained for Br in TMN was almost one order of magnitude higher median of previously reported means but inside the range of means [66,67].…”

Section: Differences Between Mean Values (Msem) Of Br Ca CL I K Mg M...supporting

confidence: 89%

“…The comparison of our results with published data for Br, Ca, Cl, I, K, Mg, Mn, and Na mass fraction in TBN [56][57][58][59][60][61][62][63][64][65] and TMN [56,59,62,[66][67][68][69][70] is shown in Table 3. A number of values for ChEs mass fractions were not expressed on a dry mass basis by the authors of the cited references.…”

Section: Resultsmentioning

confidence: 62%

See 2 more Smart Citations

Distinguish Thyroid Malignant from Benign Alterations using Neutron Activation Analysis of Chemical Element Contents in Nodular Tissue

Zaichick¹

2022

JCCRS

View full text Add to dashboard Cite

Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in chemical elements (ChEs) contents in nodular tissue for diagnosis of thyroid malignancy. Contents of eight ChEs including bromine (Br), calcium (Ca), chlorine (Cl), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), and sodium (Na) were prospectively evaluated in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using instrumental neutron activation analysis. It was observed that in TMN tissue the mass fractions of Br and I are approximately 2.9 and 14 times, respectively, lower, while the mass fraction of Ca, K, and Mg are 94%, 56%, and 36%, respectively, higher than in TBN tissue. Contents of Cl, Mn, and Na found in the TBN and TMN groups of nodular tissue samples were similar. Finally, it was proposed to use the I mass fraction and I/Ca, I/K, and I/Mg mass fraction ratios in a needle-biopsy of thyroid nodules as a potential tool to diagnose thyroid malignancy. Further studies on larger number of samples are required to confirm our findings and proposals.

show abstract

Section: Differences Between Mean Values (Msem) Of Br Ca CL I K Mg M...supporting

confidence: 90%

Section: Differences Between Mean Values (Msem) Of Br Ca CL I K Mg M...supporting

confidence: 89%

See 1 more Smart Citation

Distinguish Thyroid Malignant from Benign Alterations using Neutron Activation Analysis of Chemical Element Contents in Nodular Tissue

Zaichick¹

2022

JCCRS

View full text Add to dashboard Cite

show abstract

“…One study observed higher levels of Ti, V, Cr, Mn, Co, Fe, and Sr in cancerous tissues compared to the normal thyroid tissues [36]. While comparing their observation with another study which also studied trace elements in thyroid, both studies established consistent concentrations of K, Ca, and I, while variations were observed in the concentration of Cu, Zn, and Fe in cancerous thyroid compared to noncancerous tissues [36, 37]. Zn concentration in adenoma and cancerous thyroid was found to be lower than that in normal tissues, an observation consistent with other findings in the study of kidney and hair samples, respectively [38, 39].…”

Section: Trace Metal Concentrations In Human Tissuesmentioning

confidence: 99%

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Mulware

2013

Journal of Biophysics

View full text Add to dashboard Cite

The effect of high or low levels of trace metals in human tissues has been studied widely. There have been detectable significant variations in the concentrations of trace metals in normal and cancerous tissues suggesting that these variations could be a causative factor to various cancers. Even though essential trace metals play an important role such as stabilizers, enzyme cofactors, elements of structure, and essential elements for normal hormonal functions, their imbalanced toxic effects contribute to the rate of the reactive oxygen species (ROS) and formation of complexities in the body cells which may lead to DNA damage. The induction of oxidative-induced DNA damage by ROS may lead to isolated base lesions or single-strand breaks, complex lesions like double-strand breaks, and some oxidative generated clustered DNA lesions (OCDLs) which are linked to cell apoptosis and mutagenesis. The difference in published works on the level of variations of trace metals in different cancer tissues can be attributed to the accuracy of the analytical techniques, sample preparation methods, and inability of taking uniform samples from the affected tissues. This paper reviews comparative trace elemental concentrations of cancerous and noncancerous tissues using PIXE that has been reported in the published literature.

show abstract

“…The comparison of our results with published data for Br, Cu, Fe, Rb, Sr, and Zn mass fraction in normal and adenomatous thyroid [9,[52][53][54][55][56][57][58][59][60][61][62] is shown in Table 3.…”

Section: Resultsmentioning

confidence: 81%

Evaluation of Trace Elements in Thyroid Adenomas Using Energy Dispersive X-Ray Fluorescent Analysis

Zaichick¹

2021

J NanoSci Res Rep

View full text Add to dashboard Cite

Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of trace elements (TE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to examine the content of bromine (Br), cooper (Cu), iron (Fe), rubidium (Rb), strontium (Sr), and zinc (Zn) in the normal and in adenomatous thyroid. Thyroid tissue levels of six TE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. It was found that contents of Br and Cu were significantly higher (25.8 and 4.16 times, respectively) and content of Sr were significantly lower (39%) in adenomatous thyroid in comparison with normal level. There are considerable changes in TE contents in the adenomatous thyroid.

show abstract

Multielemental analysis of human thyroid glands using particle induced X-ray emission (PIXE)

Cited by 21 publications

References 7 publications

Distinguish Thyroid Malignant from Benign Alterations using Neutron Activation Analysis of Chemical Element Contents in Nodular Tissue

Distinguish Thyroid Malignant from Benign Alterations using Neutron Activation Analysis of Chemical Element Contents in Nodular Tissue

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Evaluation of Trace Elements in Thyroid Adenomas Using Energy Dispersive X-Ray Fluorescent Analysis

Contact Info

Product

Resources

About