2002
DOI: 10.1002/mrm.10219
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Multiecho segmented EPI with z‐shimmed background gradient compensation (MESBAC) pulse sequence for fMRI

Abstract: A MultiEcho Segmented EPI with z-shimmed BAckground gradient Compensation (MESBAC) pulse sequence is proposed and validated for functional MRI (fMRI) study in regions suffering from severe susceptibility artifacts. This sequence provides an effective tradeoff between spatial and temporal resolution and reduces image distortion and signal dropout. The blood oxygenation level-dependent (BOLD)-weighted fMRI signal can be reliably obtained in the region of the orbitofrontal cortex (OFC). To overcome physiological … Show more

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Cited by 30 publications
(24 citation statements)
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“…Although z-shimming leads to a prolongation of the total acquisition time by the necessity to acquire multiple images, it has shown to considerably improve fMRI examinations in problematic areas. Recently the MESBAC sequence has been proposed, in which multiple data with four different z-shim values are acquired in a single data acquisition (43).…”
Section: Signal Behavior In Bold Fmrimentioning
confidence: 99%
“…Although z-shimming leads to a prolongation of the total acquisition time by the necessity to acquire multiple images, it has shown to considerably improve fMRI examinations in problematic areas. Recently the MESBAC sequence has been proposed, in which multiple data with four different z-shim values are acquired in a single data acquisition (43).…”
Section: Signal Behavior In Bold Fmrimentioning
confidence: 99%
“…However, these methods [8][9][10] determine the z-shim values to acquire on an empirical basis which is subjective and results in a compromised solution which can be far from optimal. Z-shim methods with in-built calibration have been developed [11][12][13][14], but these tend to use lengthy calibration procedures which expend valuable examination time, or operator intervention which introduces subjective errors into the correction.…”
Section: Introductionmentioning
confidence: 99%
“…Other z-shim allied methods have used multi-echo sequences to collect limited numbers of z-shims [8][9][10][11], with [10] and [11] acquiring two z-shims after a single excitation by using partial Fourier acquisition. However, these methods [8][9][10] determine the z-shim values to acquire on an empirical basis which is subjective and results in a compromised solution which can be far from optimal.…”
Section: Introductionmentioning
confidence: 99%
“…The OFC, the ventral surface of the human forebrain, is the subject of intense investigation in multiple neuroscience disciplines [16]. Since the noise characteristics of OFC BOLD data area are heavily influenced by static magnetic field gradients present in the lower brain, specialized MRI acquisition strategies have been developed to compensate for them [23]. Data from an actual FMRI experiment is used to demonstrate Bayesian source separation, instead of a simulation that attempts to replicate these circumstances.…”
Section: Introductionmentioning
confidence: 99%