Multidrug-resistant Mycobacterium tuberculosis and associated risk factors in Oromia Region of Ethiopia

Mulisa, Girma; Workneh, Tilaye; Hordofa, Niguse; Suaudi, Mohamed; Abebe, Gemeda; Jarso, Godana

doi:10.1016/j.ijid.2015.08.013

Cited by 83 publications

(146 citation statements)

References 20 publications

(25 reference statements)

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“…This study conducted an analysis of sputum samples from patients with presumed MDR-TB and identified a high percentage of MDR-TB strains. One explanation may be close contact with known TB and MDR-TB patients, an association that was reported in several studies [9][10][11][12]. However, other risk factors associated with MDR-TB may be age, previous history of TB, HIV coinfection and alcohol consumption but not TB contact as reported elsewhere [13].…”

Section: Discussionmentioning

confidence: 87%

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Suthum

Samosornsuk

2020

J Infect Dev Ctries

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Introduction: Multidrug-resistant tuberculosis (MDR-TB) is commonly found in Thailand especially in the public health region 5, the Western region of Thailand. This study’s aim was to characterize katG, inhA, rpoB and pncA genes in Mycobacterium tuberculosis. Methodology: One hundred strains of Mycobacterium tuberculosis (MTB) were isolated from sputum samples of MDR-TB risk patients in the laboratory of the Office of Disease Prevention and Control 5th Ratchaburi province, Thailand from January to December 2015. Drug susceptibility testing (DST) was performed using a BACTEC MGIT 960 system. Furthermore, the genes katG, inhA, rpoB and pncA were characterized by DNA sequencing. Results: Of a total of 100 MTB samples which underwent drug susceptibility testing, 42% showed isoniazid (INH) and rifampicin (RIF) resistance, and a further 25% showed INH mono-resistance (25%). The most common gene mutations found using DNA sequencing were katG_Ser315Thr (70%), rpoB_Ser531leu (81%) and pncA_Ile31Thr (84%). The common mutation of pncA_Ile31Thr substitution was detected in 26 of 91 (29%) pyrazinamide (PZA) susceptible isolates. Conclusion: Using DNA sequencing to screen for gene mutations conferring drug resistance may be feasible and use less time than using DST to detect resistance patterns.

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Section: Discussionmentioning

confidence: 87%

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Suthum

Samosornsuk

2020

J Infect Dev Ctries

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“…This is even better than the 20% reduction rate targeted by WHO in 2015 and to be achieved in 2020. 31 The overall declining trend of TB within the recent three years is comparable to the national level, 210/100,000 in 2014, 32 ,200/100,000 in 2015, 33 ,196/100,000 in 2017 34 and 172/100,000 in 2018. 32 Similar studies from Zambia, 35 Zimbabwe, 36 Thailand, 37 Saudi Arabia 38 and United Kingdom 24 reported an increasing trend of TB.…”

Section: Annual Detection Ratementioning

confidence: 78%

<p>Six Years Trend Analysis of Tuberculosis in Northwestern Tigrai, Ethiopia; 2019: A Retrospective Study</p>

Negash¹,

Legese²,

Adhanom³

et al. 2020

IDR

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Background: Ethiopia is one of the 22 high tuberculosis burden countries. In our country. there are limited published data to show the trend analysis of tuberculosis. Hence, we designed this trend analysis to fill the information gap in our study area. Institutional based retrospective cross-sectional study was employed from 2013 to 2018 to determine the trend analysis of tuberculosis among tuberculosis presumptive clients in Northwestern Tigrai. We have used a standard checklist to extract the data. There were some missing data from the logbooks which are then excluded from the analysis. Results: A total of 7793 tuberculosis presumptive clients were requested for laboratory diagnosis of which about 7639 results had a valid result for X-pert MTB/Rif assay. The overall detection rate of tuberculosis was found to be 9.9% (756/7639). Of the total tuberculosis cases, 8.7 % (66/756) were rifampicin-resistant. The trend of tuberculosis across the six years was fluctuating with a declining trend in the recent three years. HIV infection and being presumptive to drug resistance were associated with tuberculosis detection. Conclusion: Although there was a cumulative declining trend of tuberculosis within the last six years, prevention and control strategies still need to be improved to achieve the stop tuberculosis strategy. To create a world free of tuberculosis, there should be quality service provision regarding tuberculosis case detection and treatment.

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“…Previous treatment with a second-line injectable drug is the strongest risk factor for XDR-TB 80 , however various studies have linked being female as another major risk factor for MDR and XDR-TB. 81,82 Treatment needs to be offered in ways that maximises patient adherence to improve positive TB treatment outcome rates. Social factors due to work schedules of men and fear of stigma for women need to be considered and addressed, in order to provide appropriate interventions for both sexes and reduce treatment dropout rates.…”

Section: Sex Differences In Treatmentmentioning

confidence: 99%

Sex Bias in Tuberculosis in the Developing World

Shaw¹,

Purdy²

2019

AJUR

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Tuberculosis (TB), the most deadly global single organism infectious disease, kills nearly twice as many men as women. Understanding the factors that drive this bias in TB mortality is an important aspect of the global effort to reduce the enormous burden of this disease in the developing world. One third of the world’s population is estimated to be infected TB, with Low and Middle Income Countries (LMIC) bearing the greatest disease burden. In LMIC sex bias in TB is influenced by sociocultural, behavioural as well as biological factors, with dynamic interactions between reporting variables, other confounding variables and physiological mechanisms, which each influence one another to produce the male-biased sex ratio observed in TB transmission, prevalence and mortality. While confounding factors are addressed in the existing global drive to tackle TB it is the biological aspects of sex bias in TB that present specific challenges for diagnosis and treatment in men and women as they potentially influence future immunological-based interventions to treat TB.

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Multidrug-resistant Mycobacterium tuberculosis and associated risk factors in Oromia Region of Ethiopia

Cited by 83 publications

References 20 publications

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

<p>Six Years Trend Analysis of Tuberculosis in Northwestern Tigrai, Ethiopia; 2019: A Retrospective Study</p>

Sex Bias in Tuberculosis in the Developing World

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