“…Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptosis of human HL-60 leukemia cells: The role of mitochondrial permeability transition pore and DNA damage anti-HIV (Okano et al, 1996), and cytotoxic and antitumor activities (Tischler et al, 1992;Itokawa et al, 1993;MataGreenwood et al, 2001;Murakami et al, 2004;von Bueren et al, 2007;Silva et al, 2009). Since the use of bruceantin (Kupchan et al, 1973) in phase II breast cancer and melanoma clinical trials and its subsequent withdrawal due to the concerns about toxicity (Wiseman et al, 1982;Arseneau et al, 1983), studies on the antitumor properties of quassinoids have increased steadily (Okano et al, 1985;Mata-Greenwood et al, 2001;Guo et al, 2005a).…”