Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids

Murakami, Chika; Fukamiya, Narihiko; Tamura, Sadaaki; Okano, Masayoshi; Bastow, Kenneth F.; Tokuda, Harukuni; Mukainaka, Teruo; Nishino, H; Lee, Kuo Hsiung̀

doi:10.1016/j.bmc.2004.06.045

Cited by 47 publications

(37 citation statements)

References 22 publications

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“…Quassinoids isolated from Ailanthus spp. possess several biological activities including anti-tumor [5], anti-viral [6,7], anti-tuberculosis [8] properties reported in a Review [9]. Quassinoids were also shown to be the active principles responsible for the anti-malarial activity of Ailanthus altissima.…”

Section: Introductionmentioning

confidence: 94%

Anti-plasmodial activity of Ailanthus excelsa

et al. 2008

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The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC 50 4.6 and 2.8 μg/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 μg/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC 50 of 13.43 ± 1.74 μg/ml) and of the haem detoxification to haemozoin.

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Section: Introductionmentioning

confidence: 94%

Anti-plasmodial activity of Ailanthus excelsa

et al. 2008

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“…Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptosis of human HL-60 leukemia cells: The role of mitochondrial permeability transition pore and DNA damage anti-HIV (Okano et al, 1996), and cytotoxic and antitumor activities (Tischler et al, 1992;Itokawa et al, 1993;MataGreenwood et al, 2001;Murakami et al, 2004;von Bueren et al, 2007;Silva et al, 2009). Since the use of bruceantin (Kupchan et al, 1973) in phase II breast cancer and melanoma clinical trials and its subsequent withdrawal due to the concerns about toxicity (Wiseman et al, 1982;Arseneau et al, 1983), studies on the antitumor properties of quassinoids have increased steadily (Okano et al, 1985;Mata-Greenwood et al, 2001;Guo et al, 2005a).…”

Section: Research Articlementioning

confidence: 99%

Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptosis of human HL-60 leukemia cells: The role of mitochondrial permeability transition pore and DNA damage

Cavalcanti¹,

Costa²,

Carvalho³

et al. 2012

Pharmaceutical Biology

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“…Other quassinoids [e.g., brusatol (H2)] and quassinoid glycosides [e.g., bruceoside B (H3)] from B. javanica have been studied extensively for antitumor [89][90][91][92] and cancer chemopreventive [93] effects. A recent review of biologically active quassinoids discussed their potential for drug design [94].…”

Section: Anticancer and Antitumor Compoundsmentioning

confidence: 99%

Plant-derived natural product research aimed at new drug discovery

et al. 2008

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Many important bioactive compounds have been discovered from natural sources using bioactivity-directed fractionation and isolation (BDFl) [Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78:431-441]. Continuing discovery has also been facilitated by the recent development of new bioassay methods. These bioactive compounds are mostly plant secondary metabolites, and many naturally occurring pure compounds have become medicines, dietary supplements, and other useful commercial products. Active lead compounds can also be further modified to enhance the biological profiles and developed as clinical trial candidates. In this review, the authors will summarize research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors' laboratories as antitumor and anti-HIV clinical trial candidates.

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Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids

Cited by 47 publications

References 22 publications

Anti-plasmodial activity of Ailanthus excelsa

Anti-plasmodial activity of Ailanthus excelsa

Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptosis of human HL-60 leukemia cells: The role of mitochondrial permeability transition pore and DNA damage

Plant-derived natural product research aimed at new drug discovery

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