Multidrug - Resistant Acinetobacter Species Infection among Neonates

Abstract

Background: Multidrug resistant Acinetobacter infection has emerged as an important pathogen in neonatal sepsis in the recent years causing morbidity as well as mortality. Methods: Neonates admitted with sepsis in NICU from Jan 2014 to Dec.2014 were retrospectively analysed to find out the incidence, clinical features, antibiotic sensitivity pattern and the risk factors associated with mortality in culture positive Acinetobacter sepsis. Results: Incidence of neonatal sepsis was 11.3% (26/230).Neonatal sepsis caused by Acinetobacter spp was 5.65% (13/230). Pure growth of Acinetobacter was obtained in 13 and all of them were multidrug resistant. Resistance to Meropenem was 50%.Out of 13, six were early onset and seven were late onset sepsis. The major signs were poor perfusion (9/13), hypotension (9/13) and respiratory distress (13/13). Mortality due to Acinetobacter neonatal sepsis was 76.92% (10/13 ).The major risk factors associated with death in Acinetobacter sepsis were female sex, prematurity (<30 weeks) , birth weight less than 1500 gm and normal deliveries. Conclusion: Multidrug resistant Acinetobacter infection is fatal, particularly in premature and very low birth weight neonates.

Multidrug Resistant Acinetobacter Species Infection among Neonatal Sepsis

“…This study showed with gestational age lower than 36 weeks, actinobacteria prevalence was significantly higher in females than males. and this was supported by Keskar et al (15) who revealed that Acinetobacter cases are more common in females, babies under 1500 g and under 30 weeks gestation than non-acinetobacter cases. Acinetobacter cases were less common among males, newborns with a birth weight of more than 1500 g, gestational ages of more than 30 weeks, and normal deliveries, compared to non-Acinetobacter cases.…”