Multidrug Resistance Gene-1 Is a Useful Predictor of Paclitaxel-Based Chemotherapy for Patients with Ovarian Cancer

Kamazawa, Shunji; Kigawa, Junzo; Kanamori, Yasunobu; Itamochi, Hiroaki; Sato, Shinya; Iba, Takahiro; Terakawa, Naoki

doi:10.1006/gyno.2002.6738

Cited by 97 publications

(69 citation statements)

References 14 publications

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“…Importantly, it has been demonstrated that MDR1 and MRP2, as well as MRP3 and MRP7, mediate paclitaxel transport [7][8][9][10]. However, exposing SK-OV-3 cells transiently overexpressing OATP1B1 and OATP1B3 to paclitaxel decreased their IC 50 , indicating that the sensitivity of the ovarian cancer cells to paclitaxel can be modulated by OATP1B1/1B3 expression levels.…”

Section: Discussionmentioning

confidence: 99%

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Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport

Svoboda

Wlcek

Taferner

et al. 2011

Biomedicine & Pharmacotherapy

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Our results revealed OATP1B1 and OATP1B3 as high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues, suggesting a role for these polypeptides in the disposition of paclitaxel during therapy. Conclusions:Our results revealed OATP1B1 and OATP1B3 as high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues, suggesting a role for these polypeptides in the disposition of paclitaxel during therapy.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, taxane resistance due to overexpression of P-glycoprotein (MDR1) has been shown in ovarian cancer [7].…”

Section: Introductionmentioning

confidence: 99%

Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport

Svoboda

Wlcek

Taferner

et al. 2011

Biomedicine & Pharmacotherapy

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“…With a threshold P-value (＜0.05 with FDR), we identified genetic polymorphisms (Gv) and transcriptional profiles (Ts) in the anticancer agent-related pathways as indicative markers for survival after the administration of anticancer drugs (platinum and taxane agents) with a trial set of ovarian cancer (OV) samples (n = 30). To our knowledge, whereas previous studies reported the taxane-base anticancer agent efflux functions of ABCC1 and NR1I2 (14,15), the association of their genetic variations to the individual variation of general treatment of OV (platinum-taxane) has been firstly suggested in our study. The transcriptional contribution of CYPA5 was identified in our study meanwhile genetic association of CYPA5 was taxane-base drug clearance with OV tissues (16) (P = 6.12 × 10 -3…”

Section: Identified Candidates Of Indicative Markers In the Trial Setmentioning

confidence: 80%

Relationships between genetic polymorphisms and transcriptional profiles for outcome prediction in anticancer agent treatment

Paik

Lee²,

Lee³

2010

BMB Reports

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“…P-gp functions as an efflux pump to decrease the intracellular accumulation of a variety of lipophilic drugs, including paclitaxel (25). Previous studies showed that P-gp contributed to paclitaxel resistance and MDR-1 gene expression might be a useful predictor for combination paclitaxel based chemotherapy in ovarian cancer cells (26). Cellular P-gp can be detected in protein levels by Western blot analysis with monoclonal antibodies against human P-gp.…”

Section: Discussionmentioning

confidence: 99%

Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro

Liu²,

Mao³

et al. 2009

Oncol Rep

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Abstract. Ovarian cancer has the highest mortality rate among gynecologic malignancies in the world, and the development of drug resistance is a major impediment toward successful treatment of the desease. Emodin has been reported to sensitize human tumor cells to chemotherapeutic agents. The present study investigated whether emodin could overcome chemoresistance of A2780/taxol cells. Cells were treated with different concentration of emodin alone or combined with paclitaxel, then the cell viability was measured by MTT and the apoptosis was determined by flow cytometric analysis. The changes of mRNA and protein were examined by QRT-PCR and Western blotting. The function of P-glycoprotein was also determined by flow cytometry. The results showed that emodin induced apoptosis alone at a high concentration and increased paclitaxel-induced apoptosis at a low concentration. It enhanced the sensitivity of A2780/taxol cells to paclitaxel with down-regulation of P-glycoprotein, XIAP and survivin. Taken together, the results demonstrated a dual role for emodin in the inhibition of drug resistant ovarian tumor growth by increasing paclitaxel cellular concentration and re-sensitizing the resistant cells to paclitaxel. Our results suggest the possibility of an innovative chemotherapeutic strategy that uses emodin in combination with paclitaxel to increase the sensitivity of tumor cells.

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Multidrug Resistance Gene-1 Is a Useful Predictor of Paclitaxel-Based Chemotherapy for Patients with Ovarian Cancer

Cited by 97 publications

References 14 publications

Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport

Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport

Relationships between genetic polymorphisms and transcriptional profiles for outcome prediction in anticancer agent treatment

Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro

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