Multidisciplinary management of a hepatic and renal transplant patient with Alagille syndrome

Maisonneuve, Emeline; Morin, Francine; Crochetière, Chantal; Lemyre, Emmanuelle; Bigras, JL; Leduc, Line; Girardin, Catherine; Bilodeau, Marc

doi:10.1016/j.ijoa.2012.08.003

Cited by 5 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The author(s) received no financial support for the research, authorship, and/or publication of this article. 13 1 Yes IUGR -terminated at 24 weeks' gestation, 640g female Ferrarese 14 1 No Uncomplicated pregnancy -delivery at 38 weeks Maissoneuve 15 1 Yes Mother liver/kidney transplant Uncomplicated pregnancy ; spontaneous labour 37 weeks; 2080 g female Romero 16 1 ?…”

Section: Fundingmentioning

confidence: 99%

Alagille syndrome and pregnancy

Morton

Kumar

2019

Obstet Med

View full text Add to dashboard Cite

Alagille syndrome is an autosomal dominant multisystem disorder with an estimated frequency of 1 in 30 000. Only a small number of pregnancy outcomes have been described in women with this condition. The report details the pregnancy outcomes of two women with Alagille syndrome. We also review the literature pertaining to this syndrome in pregnancy and demonstrate a significant risk of adverse pregnancy outcomes.

show abstract

Section: Fundingmentioning

confidence: 99%

Alagille syndrome and pregnancy

Morton

Kumar

2019

Obstet Med

View full text Add to dashboard Cite

show abstract

The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development

Romero

2018

Alagille Syndrome

View full text Add to dashboard Cite

Management of adults with Alagille syndrome

et al. 2023

View full text Add to dashboard Cite

Alagille syndrome (ALGS) is a complex rare genetic disorder that involves multiple organ systems and is historically regarded as a disease of childhood. Since it is inherited in an autosomal dominant manner in 40% of patients, it carries many implications for genetic counselling of patients and screening of family members. In addition, the considerable variable expression and absence of a clear genotype–phenotype correlation, results in a diverse range of clinical manifestations, even in affected individuals within the same family. With recent therapeutic advancements in cholestasis treatment and the improved survival rates with liver transplantation (LT), many patients with ALGS survive into adulthood. Although LT is curative for liver disease secondary to ALGS, complications secondary to extrahepatic involvement remain problematic lifelong. This review is aimed at providing a comprehensive review of ALGS to adult clinicians who will take over the medical care of these patients following transition, with particular focus on certain aspects of the condition that require lifelong surveillance. We also provide a diagnostic framework for adult patients with suspected ALGS and highlight key aspects to consider when determining eligibility for LT in patients with this syndrome.

show abstract

Multidisciplinary management of a hepatic and renal transplant patient with Alagille syndrome

Cited by 5 publications

References 21 publications

Alagille syndrome and pregnancy

Alagille syndrome and pregnancy

The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development

Management of adults with Alagille syndrome

Contact Info

Product

Resources

About