Multidisciplinary investigation of a multicountry outbreak of Salmonella Stanley infections associated with turkey meat in the European Union, August 2011 to January 2013

Kinross, Pete; Alphen, Loek van; Martínez-Urtaza, Jaime; Struelens, Marc; Takkinen, Johanna; Coulombier, D; Mäkelä, P; Bertrand, Sophie; Mattheus, Wesley; Schmid, Daniela; Kanitz, Elisabeth Eva; Rücker, Viktoria; Krisztalovics, Katalin; Pászti, Judit; Szogyenyi, Zsuzsanna; Lancz, Z.; Rabsch, Wolfgang; Pfefferkorn, Beatrice; Hiller, Petra; Mooijman, Kirsten A.; Gossner, Céline M

doi:10.2807/1560-7917.es2014.19.19.20801

Cited by 30 publications

(18 citation statements)

References 9 publications

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“…1B; see Table S3 (Table S3). The outbreak of Salmonella serotype Stanley in 2012 was traced back to Hungary by joint European Centre for Disease Prevention and Control (ECDC) efforts (41). Also notable is the stable, low prevalence of Salmonella serotype Newport (annually between 0.49 and 0.80%), which is comparable to the European average (1) but 10-fold lower than the global average (42,43).…”

Section: Resultsmentioning

confidence: 65%

Trends in Serotype Distribution and Antimicrobial Susceptibility in Salmonella enterica Isolates from Humans in Belgium, 2009 to 2013

Ceyssens

Mattheus

Vanhoof

et al. 2015

Antimicrob Agents Chemother

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Although 377 different serotypes were identified, the landscape is dominated by S. enterica serovars Typhimurium (55%) and Enteritidis (19%) in a ratio which is inverse to European Union averages. With outbreaks of Salmonella serotypes Ohio, Stanley, and Paratyphi B variant Java as prime examples, 20 serotypes displayed significant fluctuations in this 5-year period. Typhoid strains account for 1.2% of Belgian salmonellosis cases. Large-scale antibiotic susceptibility analyses (n ‫؍‬ 4,561; panel of 12 antibiotics) showed declining resistance levels in S. Enteritis and Typhimurium isolates for 8 and 3 tested agents, respectively. Despite low overall resistance to ciprofloxacin (4.4%) and cefotaxime (1.6%), we identified clonal lineages of Salmonella serotypes Kentucky and Infantis displaying rising resistance against these clinically important drugs. Quinolone resistance is mainly mediated by serotype-specific mutations in GyrA residues Ser83 and Asp87 (92.2% not wild type), while an additional ParC_Ser80Ile mutation leads to ciprofloxacin resistance in 95.5% S. Kentucky isolates, which exceeds European averages. Plasmid-mediated quinolone resistance (PMQR) alleles qnrA1 (n ‫؍‬ 1), qnrS (n ‫؍‬ 9), qnrD1 (n ‫؍‬ 4), and qnrB (n ‫؍‬ 4) were found in only 3.0% of 533 isolates resistant to nalidixic acid. In cefotaxime-resistant isolates, we identified a broad range of Ambler class A and C ␤-lactamase genes (e.g., bla SHV-12 , bla TEM-52 , bla CTX-M-14 , and bla CTX-M-15 ) commonly associated with members of the family Enterobacteriaceae. In conclusion, resistance to fluoroquinolones and cefotaxime remains rare in human S. enterica, but clonal resistant serotypes arise, and continued (inter)national surveillance is mandatory to understand the origin and routes of dissemination thereof.

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Section: Resultsmentioning

confidence: 65%

Trends in Serotype Distribution and Antimicrobial Susceptibility in Salmonella enterica Isolates from Humans in Belgium, 2009 to 2013

Ceyssens

Mattheus

Vanhoof

et al. 2015

Antimicrob Agents Chemother

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“…Additionally, the isolated serovars were among the most frequently implicated in human cases in Europe, highlighting the emergence of certain serovars in the EU, including Latvia [2]. This covers the increases in the prevalence of S. Derby and S. Stanley in food and clinical cases, and confirmation of the monophasic S. Typhimurium variant 4, [5], 12; i:-;, which became one of the most predominant in several European countries [2,19,26].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antimicrobial resistance of <i>Salmonella</i> in meat and meat products in Latvia

Terentjeva¹,

Avsejenko²,

Streikiša³

et al. 2017

Ann Agric Environ Med.

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Terentjeva M, Avsejenko J, Streikiša M, Utināne A, Kovaļenko K, Bērziņš A. Prevalence and antimicrobial resistance of Salmonella in meat and meat products in Latvia. Ann Agric Environ Med. 2017; 24(2): 317-321. AbstractIntroduction and objective. Salmonella is a foodborne pathogen which causes gastrointestinal illness in consumers, and exhibits resistance to antimicrobials of veterinary and clinical significance. The aim of this study is to detect the prevalence and antimicrobial resistance of Salmonella isolates from meat in Latvia. Materials and method. A total of 3,152 samples of raw and ready-to-eat (RTE) meats were collected during the official control and in-house control procedures in 2015. Samples were tested in accordance with ISO 6579:2002. All S. Typhimurium, S. Enteritidis and other isolates recovered from the official control samples (S. Derby, S. Give) were tested for antimicrobial resistance. The minimum inhibitory concentration (MIC) values were investigated in line with the requirements of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results. The prevalence of Salmonella was 0.8% (25/3152). The highest prevalence (1.5%) of Salmonella was found in minced meat and meat preparations (7/481), while the lowest (0%) in frozen meat and meat preparations (0/349) and RTE meats (0/364). The most common serovars were S. Typhimurium (36%, 9/25) and S. Derby (32%, 8/25). In total, 62% (13/21) of Salmonella isolates were resistant to at least one antimicrobial agent. Altogether, 40% (8/20) of isolates were resistant to sulfamethoxazole, 25% (5/20) to nalidixic acid, ciprofloxacin, ampicillin and 20% (4/20) to tetracycline. All isolates were susceptible to ceftazidime, cefotaxime, meropenem, azithromycin and tigecycline. S. Typhimurium exhibited antimicrobial resistance more often (87.5%) than other serovars. Conclusion. The study shows that the presence of Salmonella in meat, together with the high prevalence of resistant strains, is a significant public health related issue in Latvia.

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“…In this issue of Eurosurveillance, Kinross et al report about a cross-border outbreak of an unusual strain of serovar Salmonella Stanley that occurred in 2011-12 with more than 700 non-travel related human cases reported in 10 EU countries [1]. This number probably only represents the tip of the iceberg because additional cases might have not been captured by the surveillance systems in different countries.…”

Section: Success Of Salmonella National Control Programmesmentioning

confidence: 99%

“…More recently, further human cases of salmonellosis due to a S. Stanley strain exhibiting similar microbiological characteristics (i.e. resistance to ciprofloxacin) were detected and also linked to turkey meat in Austria in April 2014, suggesting that the outbreak may still be continuing with one or several similar sources [1,22].…”

Section: Success Of Salmonella National Control Programmesmentioning

confidence: 99%

Controlling Salmonella along the food chain in the European Union - progress over the last ten years

Hugas

Belœil

2014

Eurosurveillance

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Multidisciplinary investigation of a multicountry outbreak of Salmonella Stanley infections associated with turkey meat in the European Union, August 2011 to January 2013

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 30 publications

References 9 publications

Trends in Serotype Distribution and Antimicrobial Susceptibility in Salmonella enterica Isolates from Humans in Belgium, 2009 to 2013

Trends in Serotype Distribution and Antimicrobial Susceptibility in Salmonella enterica Isolates from Humans in Belgium, 2009 to 2013

Prevalence and antimicrobial resistance of <i>Salmonella</i> in meat and meat products in Latvia

Controlling Salmonella along the food chain in the European Union - progress over the last ten years

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