Multidisciplinary examination of patients with illness attributed to dental fillings

Langworth, Sven; Björkman, Lars; Elinder, Carl Gustaf; Järup, Lars; Savlin, P.

doi:10.1046/j.1365-2842.2002.00963.x

Cited by 59 publications

(52 citation statements)

References 22 publications

(22 reference statements)

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“…Multiple human studies, however, have failed to establish causation [74][75][76][77][78][79][80][81]. Some studies have reported improvement in a variety of symptoms after the removal of mercury amalgam; however, these studies have not clearly established a link between amalgam removal and improvement of symptoms [82,83]. It should be noted that removal of mercury amalgam appears to increase plasma mercury by three-to fourfold for a short time after removal [84,85].…”

Section: Dental Amalgammentioning

confidence: 99%

Heavy metal poisoning: management of intoxication and antidotes

Rusyniak

Arroyo

Acciani

et al. 2010

Experientia Supplementum

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Abstract. Of the known elements, nearly 80% are either metals or metalloids. The highly reactive nature of most metals result in their forming complexes with other compounds such oxygen, sulfide and chloride. Although this reactivity is the primary means by which they are toxic, many metals, in trace amounts, are vital to normal physiological processes; examples include iron in oxygen transport, manganese and selenium in antioxidant defense and zinc in metabolism. With these essential metals toxicity occurs when concentrations are either too low or too high. For some metals there are no physiological concentrations that are beneficial; as such these metals only have the potential to cause toxicity. This chapter focuses on four of these: arsenic, mercury, lead and thallium.

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Section: Dental Amalgammentioning

confidence: 99%

Heavy metal poisoning: management of intoxication and antidotes

Rusyniak

Arroyo

Acciani

et al. 2010

Experientia Supplementum

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“…It has been feared that mercury in amalgam may cause a variety of symptoms. This so-called 'amalgam disease' is however controversial, and although some authors claim proof of symptom relief after removal of dental amalgam fillings (Lindh et al, 2002); there is no scientific evidence of this (Langworth et al, 2002). Mercury exposure affects the central nervous system, brain functions, causes DNA and chromosomal damage, and causes reproductive problems.…”

Section: Toxicology Of Mercurymentioning

confidence: 99%

Heavy Metals of Special Concern to Human Health and Environment

Mansour¹

2014

Practical Food Safety

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“…So far there is no convincing evidence from epidemiological, toxicological or immunological research that 'amalgam burden' or 'amalgam hypersensitivity' (beyond rare cases of proven allergic reactions like oral lichenoid reactions) are valid pathological concepts [1,2]. Nevertheless many patients and physicians are convinced that amalgam is hazardous to health [3,4]. In 1996, a group of about 1,500 patients who attributed their chronic complaints to amalgam fillings filed a lawsuit against Degussa, the major German manufacturer of this material.…”

Section: Introductionmentioning

confidence: 99%

Prognos®in the Diagnosis of Amalgam Hypersensitivity – a Diagnostic Case-Control Study

Köhler¹,

Linde²,

Halbach

et al. 2007

Complement Med Res

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Objective: We aimed to investigate whether the Prognos® device might be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings. Participants and Methods: A diagnostic case-control study was performed in 27 patients who complained about health problems attributed to amalgam (cases), 27 healthy volunteers with amalgam fillings (controls I), and 27 healthy amalgamfree volunteers (controls II). All participants were tested before and after application of 300 mg DMPS (2.3-dimercapto- 1-propanesulfonic acid) with Prognos®, a diagnostic device for the energetic measurement of Traditional Chinese Medicine meridians. In addition, mercury was measured in blood, urine, and saliva, and a lymphocyte transformation test (LTT) was performed. Results: Diagnoses derived from the first and second Prognos® testing did not agree above chance (Cohen’s Kappa = -0.11, 95% confidence interval -0.33 to 0.10; p = 0.30). Agreement for secondary outcome measures was poor, too. Prognos® measurements did not differ between cases and controls. Correlations with measurements in urine, blood and saliva were low. Conclusion: In this study Prognos® could not be shown to be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings.

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Multidisciplinary examination of patients with illness attributed to dental fillings

Abstract: The results do not support the hypothesis that release of mercury from amalgam fillings is the cause of 'amalgam disease', but suggest that there may be various explanations for the patient's complaints.

Cited by 59 publications

References 22 publications

Heavy metal poisoning: management of intoxication and antidotes

Heavy metal poisoning: management of intoxication and antidotes

Heavy Metals of Special Concern to Human Health and Environment

Prognos®in the Diagnosis of Amalgam Hypersensitivity – a Diagnostic Case-Control Study

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