Multidisciplinary care of craniosynostosis

Buchanan, Edward P.; Xue, Yunfeng; Xue, Amy S.; Olshinka, Asaf; Lam, Sandi

doi:10.2147/jmdh.s100248

Cited by 45 publications

(44 citation statements)

References 12 publications

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“…Fibroblast growth factor receptor (FGFR) mutations are most frequently cited in association with craniosynostosis, especially syndromic types. A single genetic anomaly has still not been identified as a cause for craniosynostosis [8]. Fig.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmological outcomes of unilateral coronal synostosis in young children

et al. 2020

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Background: To report refractive outcomes, describe types of strabismus and evaluate the outcomes of surgical intervention for unilateral coronal synostosis (UCS) in paediatric patients. Methods: This study retrospectively included 30 UCS cases. Patients aged from 3 months to 6 years (median: 1.8 years) were enrolled from January 2018 to December 2019 at Shanghai Children's Hospital. Sixteen patients had all types of strabismus; 15 of these patients underwent surgery. Results: Refractive errors of 30 cases were included. In 60% of patients, astigmatism of 1.00D or more existed in not less than one eye at last record. Twenty (66.7%) patients had the larger amount of astigmatism in the contralateral eye. Fifteen patients received strabismus surgery, of whom 6 patients with monocular elevation deficiency (MED) underwent the standard Knapp procedure, with or without a horizontal deviation procedure. Fifteen cases were horizontally aligned within 5 prism dioptres (Δ). Six patients with MED (100%) had attained ≥25% elevation improvement after surgery, and the vertical deviation decreased from 25.83 Δ ± 4.92 Δ (range, 20 Δ-30 Δ) to 0.83 Δ ± 4.92 Δ after surgery (range, 0 Δ-10 Δ), for an improvement of 26.67 Δ ± 4.08 Δ (t = 16 P < 0.05). In 1 patient with esotropia, the horizontal deviation decreased from + 80 Δ to + 5 Δ after surgery. One patient was diagnosed with trichiasis and one with contralateral lacrimal duct obstruction. Conclusions: Contralateral MED was also the main type of strabismus in UCS. Superior oblique muscle palsy was still the most common, as previously reported. There is a risk of developing a higher astigmatism and anisometropia in the contralateral eye to synostosis. Other ophthalmic disorders should be treated in a timely manner. Trial registration: The study was approved by the Institutional Review Board of Shanghai Children's Hospital (approval No. 2020R023-E01) and adhered to the tenets of the Declaration of Helsinki. Ethics approval was procured on March 30, 2020. This was a retrospective study. Written informed consent was sought from the patients' parents or legal guardians. Clinical Trials Registry number: ChiCTR2000034910. Registration URL: http://www.chictr.org.cn/showproj.aspx?proj=56726.

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Section: Discussionmentioning

confidence: 99%

Ophthalmological outcomes of unilateral coronal synostosis in young children

et al. 2020

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“…However, and as a consequence of premature fusion of the calvarial suture, skull growth is restricted parallel to the affected suture; in addition, the growing brain beneath the suture is limited as well, due to the inability of the involved sutures to accommodate this structure ( 8 ). In other words, distortion of the skull shape is primarily due to a combination of lack of growth perpendicular to the fused suture, and compensatory overgrowth at the non-fused sutures ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…A single genetic anomaly has not been identified as a causal factor for the condition. The genes most frequently involved in CS include those encoding for the different fibroblast growth-factor receptors ( 3 ); these mutations lead to defects in signaling and tissue interactions, resulting in abnormal suture maturation and cranial malformation, particularly in the syndromic type ( 2 , 3 , 8 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…This condition may occur either in an isolated way –representing about 85% of cases and called Non-Syndromic Craniosynostosis (NSCS)–, or associated with more than 150 different structural malformations or syndromes (known as syndromic craniosynostoses) ( 6 ). Some commonly cited CS syndromes include Apert, Crouzon, Pfeiffer, Muenke, Saethre-Chotzen, and Antley-Bixter ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, some of the malformations result in fetal death ( 13 ). Approximately 80% of cases belong to the NSCS group ( 8 ). CS occurs more commonly overall in boys than in girls ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Non-syndromic craniosynostosis in children: Scoping review

et al. 2018

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BackgroundCraniosynostosis (CS) is a complex condition consisting of the early fusion of one or more cranial sutures in the intrauterine stage. The affected infant exhibits abnormal head shape at time of birth or shortly thereafter. It can be observed in normal individuals (non-syndromic CS or NSCS) or as a part of a multisystem syndrome. The purposes of the present article were to carry out a scoping review on Non-Syndromic CS and to discuss the most important findings retrieved.Material and MethodsThe steps of this scoping review were as follows: first, to pose a research question; second, to identify relevant studies to answer the research question; third, to select and retrieve the studies; fourth, to chart the critical data, and finally, to collate, summarize, and report the results from the most important articles. Relevant articles published over a 20-year period were identified and retrieved from five Internet databases: PubMed; EMBASE; Cochrane Library; Google Scholar, and EBSCO.ResultsFourteen articles were finally included in the present scoping review. The following four most important clinical issues are discussed: (i) normal cranial development, clinical manifestations, and pathogenesis of NCSC; (ii) clinical evaluation of NCSC; (iii) treatment and post-surgical follow-up; and (iv) additional considerations.ConclusionsNSCS may be present with associated head shapes. Multiple early surgical reconstructive options are currently available for the disorder. Pediatric Dentistry practitioners must be familiarized with this condition and form part of a multi-approach health team as those responsible for the opportune oral health care of the affected child. Key words:Craniosynostosis, cranial development, children, scoping review, dental management.

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The Developmental Interrelation Between the Nervous System and Craniofacial Complex as Evidenced from Craniofacial Malformations

Ornoy

2021

Fundamentals of Craniofacial Malformations

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Multidisciplinary care of craniosynostosis

Cited by 45 publications

References 12 publications

Ophthalmological outcomes of unilateral coronal synostosis in young children

Ophthalmological outcomes of unilateral coronal synostosis in young children

Non-syndromic craniosynostosis in children: Scoping review

The Developmental Interrelation Between the Nervous System and Craniofacial Complex as Evidenced from Craniofacial Malformations

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