Multidisciplinary Baseline Assessment of Homosexual Men With and Without Human Immunodeficiency Virus Infection

Stern, Yaakov; Marder, Karen; Bell, Karen L.; Chen, Jenn; Dooneief, George; Goldstein, S.; Mindry, Deborah; Richards, Marcus; Sano, Mary; Williams, Janet B. W.; Gorman, Jack M.; Ehrhardt, Anke Α.; Mayeux, Richard

doi:10.1001/archpsyc.1991.01810260039006

Cited by 142 publications

(65 citation statements)

References 25 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study supports and extends previous reports regarding the everyday life significance of NP impairments associated with HIV infection (Albert et al, 1995;Heaton et al, 1996;Hinkin et al, 2002;Marcotte et al, 1999;Stern et al, 1991). It is the largest such study to date and the most comprehensive in its coverage of both performance-based measures of IADLs and manifest measures of daily functioning outside of the laboratory.…”

Section: Discussionsupporting

confidence: 89%

“…HIV-infection can be associated with CNS involvement and changes in neurobehavioral status, particularly in advanced stages of the illness (Bornstein et al, 1992;Grant et al, 1987;Heaton et al, 1995;Stern et al, 1991). Neuroimaging and neuropsychological (NP) studies suggest initial preferential involvement of frontostriatal circuitries, reduction in white matter volumes, and a spotty pattern of mild NP impairments, with increasing structural abnormalities and NP impairment as HIV disease state advances (Heaton et al, 1995;Jernigan et al, 1993;Stout et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…At present, the few available studies concerning functional impact of HIV-related NP deficits suggest that these deficits are associated with impaired driving ability, worse performance on standardized work samples, increased unemployment and complaints of problems in vocational functioning and everyday living (Albert et al, 1995;Benedict et al, 2000;Heaton et al, 1996;Mapou et al, 1993;Marcotte et al, 1999;Stern et al, 1991). Of particular importance to HIV1 patients is the ability to effectively manage their antiretroviral medications.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

677

689

View full text Add to dashboard Cite

HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or "real-world" impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction0Executive Function, Learning, Attention0Working Memory and Verbal abilities most strongly and consistently predicted failures on the functional battery. Both NP impairment and impairment on the functional battery were significantly associated with subjective experiences of cognitive difficulties, as well as unemployment and increased dependence in activities of daily living; multivariate prediction models that also considered depressed mood and biological measures of disease progression revealed that impairment on the functional battery and depression were the only unique predictors of all three indicators of "real-world" functioning. The current results add to growing evidence concerning the clinical significance of HIV-associated NP impairment. Objective, laboratory based functional measures, such as those used here, may compliment NP testing in future studies directed at understanding the impact on life quality of central nervous system disorders and their treatments. Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons. (JINS, 2004, 10, 317-331.)

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

677

689

View full text Add to dashboard Cite

show abstract

“…More specifically, a BDI factor reflecting disturbance in mood and motivation was more strongly associated with neurocognitive performance than were factors representing either negative self-view or somatic disturbance. The neurocognitive domains most closely associated with the mood and motivation disturbance factor were verbal memory, executive functioning, and motor performance, all of which have been shown to be affected by HIV-infection (Bornstein et al, 1993a;Heaton et al, 1995;Stern et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…It is well established that neuropsychological compromise can occur secondary to HIV infection Bornstein et al, 1993a;Grant & Martin, 1994;Heaton et al, 1995;Hinkin, Castellon, van Gorp, & Satz, 1998;Maj et al, 1994aMaj et al, , 1994bMartin et al, 1992;Stern et al, 1991;van Gorp, Miller, Satz & Visscher, 1989;von Giesen, Baecker, Hefter, & Arendt, 2001). When present, HIV-related neurocognitive impairment can range from subtle deficits of unknown clinical significance to frank dementia syndromes that profoundly disrupt an individual's functioning and activities of daily living.…”

Section: Introductionmentioning

confidence: 99%

Components of Depression in HIV-1 Infection: Their Differential Relationship to Neurocognitive Performance

Castellon

Hardy

Hinkin

et al. 2006

Journal of Clinical and Experimental Neuropsychology

View full text Add to dashboard Cite

Both depression and neurocognitive compromise are commonly observed among persons infected with the Human Immunodeficiency Virus (HIV). To date, the majority of studies have failed to find a consistent relationship between mood and cognition among HIV-seropositive (HIV+) individuals, suggesting that these constructs are independent of one another. However, depression is a multidimensional syndrome and its measurement often utilizes multi-factorial instruments containing cognitive, affective, somatic, and motivational components. The degree to which various symptoms or dimensions of depression might be related to neuropsychological performance in HIV-1 infection is not typically explored and was a main objective of the current study. A sample of 247 HIV+ persons completed both a comprehensive neurocognitive battery and the Beck Depression Inventory (BDI) as part of a standard clinical evaluation at a major community hospital. To examine the dimensionality of the BDI, a principal components analysis was conducted which suggested a three-factor solution comprised of factors representing Self-Reproach (SR), Mood-Motivation Disturbance (MM), and Somatic Disturbance (SOM). The relationship between each of these three factors and neurocognitive performance was examined using both regression and analysis of variance techniques. These analyses showed the MM factor, more so than either the SR or SOM factors, to be associated with several aspects of neurocognitive performance, including verbal memory, executive functioning, and motor speed. These findings suggest that certain items on depression rating scales may be more indicative of central nervous system (CNS) involvement than others. The association between disturbance in mood and motivation and neurocognitive compromise may suggest that each are sequelae of disease specific mechanisms.

show abstract

A Prospective Controlled Study of Magnetic Resonance Imaging of the Brain in Gay Men and Parenteral Drug Users With Human Immunodeficiency Virus Infection

Dooneief

Bello²,

Todak³

et al. 1992

Archives of Neurology

View full text Add to dashboard Cite

show abstract

Multidisciplinary Baseline Assessment of Homosexual Men With and Without Human Immunodeficiency Virus Infection

Cited by 142 publications

References 25 publications

The impact of HIV-associated neuropsychological impairment on everyday functioning

The impact of HIV-associated neuropsychological impairment on everyday functioning

Components of Depression in HIV-1 Infection: Their Differential Relationship to Neurocognitive Performance

A Prospective Controlled Study of Magnetic Resonance Imaging of the Brain in Gay Men and Parenteral Drug Users With Human Immunodeficiency Virus Infection

Contact Info

Product

Resources

About