Multidisciplinary Aspects of Regulatory Systems Relevant to Multiple Stressors: Aging, Xenobiotics and Radiation

Rollo, C. David

doi:10.1007/978-1-4020-6335-0_13

Cited by 6 publications

(4 citation statements)

References 208 publications

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“…In particular, many channels are modulated by reversible modification of redox-sensitive cysteine or methionine residues, often in conjunction with GSH/GSSG redox status [101][102][103]. Thus, free radical theories of damage and regulation seamlessly enfold an ion channel paradigm.…”

Section: Ion Channels In Aging and Neuropathologymentioning

confidence: 98%

“…The free radical theory expanded recently from a focus on damage to recognize pervasive roles for RONS in cell signalling and diverse functions, including neuronal activity and synaptic plasticity [e.g., 103,[212][213][214][215]. Thus, SOR associated with NMDA receptors is required to activate PKC and MAPK-ERK involved in LTP [118,133,216,217].…”

Section: The Mammalian Regulatory Bauplan: It's About Timementioning

confidence: 98%

“…Electrical properties are particularly emphasized for neurons. Thus, this dynamic organization might be described as an ''Electroplasmic Cycle'' [103].…”

Section: The Mammalian Regulatory Bauplan: It's About Timementioning

confidence: 99%

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Dopamine and Aging: Intersecting Facets

Rollo

2008

Neurochem Res

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Aging encompasses life itself so understanding requires frameworks that forge unity amidst complexity. The free radical theory of aging is one example. The original focus on damage was augmented recently by appreciation that reactive oxygen and nitrogen species are essential to normal signaling and cell function. This paradigm is currently undergoing an explosive expansion fueled by the discovery that regulatory organization is a merry-go-round of redox cycling seamlessly fused to endogenous clocks. This might best be described as an "Electroplasmic Cycle." This is certainly applicable to dopaminergic neurons with their exceptional metabolic, electrical and rhythmic properties. Here I review normal aging of dopamine systems to highlight them as a valuable model. I then examine the possible integration of free radical and ion channel theories of aging. Finally, I incorporate clocks and explore the multifaceted implications of electroplasmic cycles with special emphasis on dopamine.

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Section: Ion Channels In Aging and Neuropathologymentioning

confidence: 98%

Section: The Mammalian Regulatory Bauplan: It's About Timementioning

confidence: 98%

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Dopamine and Aging: Intersecting Facets

Rollo

2008

Neurochem Res

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“…ROS signalling is essential for long-term potentiation (Kamsler and Segal 2003;Tejada-Simon et al 2005). Redox cycles critically impinge on virtually all cellular and organismal functions (Rollo 2007c) so selection to offset oxidative stress might be expected in Tg. DA neurons are exceptionally sensitive to oxidative stress which could explain alterations seen in Tg and Cr (Michel et al 2006;Rollo 2008).…”

Section: Oxidative Stress Hypothesismentioning

confidence: 99%

Modifier Selection by Transgenes: The Case of Growth Hormone Transgenesis and Hyperactive Circling Mice

et al. 2008

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Deleterious impacts of major mutations can be ameliorated by stabilising selection acting on modifier genes. We hypothesise that a new hyperactive circling mouse (counterspin: Cr) arises when modifier genes inadvertently selected to ameliorate the negative impacts of a growth hormone transgenic insertion segregate into the normal genetic background that lacks the transgene. We hypothesise that such modifiers generate a phenotype ''mirror image'' to the transgenics on the otherwise normal background. We highlight this by testing a priori hypotheses that counterspin and transgenic growth hormone mice deviate oppositely from normal mice across a broad spectrum of characteristics. Results spanning growth, sensorimotor performance, cognition and striatal neurotransmitters provide strong circumstantial evidence for the hypothesis. In a more direct test for selection in the transgenic mice, we found that those examined in 2008 slept *3 h/d less than they did 14 years ago (P \ 0.0005). This is a profound change strongly supporting the reality of modifier selection in these mice. Our results highlight that modifiers may act powerfully on genetically engineered constructs given a genetically variable background. Furthermore, we suggest that modifier selection might provide a novel method for deriving genetic models, and specifically, models phenotypically opposite to engineered constructs or natural mutations.

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Necromone Death Cues and Risk Avoidance by the Cricket Acheta domesticus: Effects of Sex and Duration of Exposure

Aksenov

Rollo

2017

J Insect Behav

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Multidisciplinary Aspects of Regulatory Systems Relevant to Multiple Stressors: Aging, Xenobiotics and Radiation

Cited by 6 publications

References 208 publications

Dopamine and Aging: Intersecting Facets

Dopamine and Aging: Intersecting Facets

Modifier Selection by Transgenes: The Case of Growth Hormone Transgenesis and Hyperactive Circling Mice

Necromone Death Cues and Risk Avoidance by the Cricket Acheta domesticus: Effects of Sex and Duration of Exposure

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