The presented paper deals with the design of a knee simulator that uses pin-on-ball configuration, ie cartilage and CoCrMo head. The translational motion consists of the cartilage and the rotating head when the load of the articulating pair is derived. The simulator meets the predetermined kinematic conditions according to the ISO 14243-3 standard, including dynamic loading. The simulator is able to record the coefficient of friction during the test, which helps to understand the biotribological processes in the knee. The structural part of the simulator is preceded by a research part, in which the existing simulators and tribometers, which helped to create this design, are analyzed. In the experimental part, specific elements (drives, sensors, etc.) are selected that meet the defined boundary conditions, and the method of friction measurement is determined. The paper concludes with an overall evaluation of the proposed knee joint simulator, which will be able to achieve the conditions according to ISO 14243-3 and at the same time record the course of the coefficient of friction between the cartilage surface and the CoCrMo head.