Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines

Olender, Dorota; Żwawiak, Justyna; Zaprutko, Lucjusz

doi:10.3390/ph11020054

Cited by 78 publications

(49 citation statements)

References 72 publications

(82 reference statements)

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“…Nitro-compounds consist of nitro functional groups bound to the carbon of alcohol, such as 2-nitro-1-propanol ( NP , C 3 H 7 NO 3 ) ( Olender et al., 2018 ). The NP and nitro-ethanol could inhibit food-born pathogens, including Salmonella , Enterococcus , Campylobacter , and Eimeria coli ( Jung et al., 2003 , 2004a ; Dimitrijevic et al., 2006 ; Horrocks et al., 2007 ).…”

Section: Introductionmentioning

confidence: 99%

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

et al. 2020

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A 2 × 3 factorial arrangement study was conducted to evaluate 3 dosages of 2-nitro-1-propanol ( NP ; 0, 150, and 200 ppm) on intestinal health of birds with or without Eimeria challenge. A total of 432 thirteen-day-old male broiler chickens were randomly allocated to 6 treatments with 8 replicate cages of 9 birds per cage. All birds were fed with treatment diets from day 13 to 21. Birds in the challenge groups were gavaged with Eimeria maxima (50,000 oocysts per bird), Eimeria tenella (50,000 oocysts per bird), and Eimeria acervulina (250,000 oocysts per bird) on day 15. Growth performance was evaluated from day 13 to 21, and gut permeability was measured by fluorescein isothiocyanate dextran on day 20. The intestinal lesion, intestinal morphology, and oocysts shedding were determined at the end of the trial. The linear and quadratic orthogonal polynomial contrasts were used to evaluate the effects of increasing NP doses in responses to Eimeria challenge. The results showed that NP was not able to maintain efficient growth performance but improved gut leakage during Eimeria infection period. On the other hand, Eimeria infection increased gut permeability ( P < 0.0001) and reduced ileal digestible energy ( IDE ) and apparent ileal digestibility ( AID ) of nitrogen. However, the increase of NP linearly enhanced IDE and AID of nitrogen ( P < 0.01). Moreover, an interaction between challenge and linear dosage effects was observed for IDE ( P = 0.0066) and AID of nitrogen ( P = 0.0462). The results indicated that NP improved nutrient digestibility and reduced total oocysts shedding in birds challenged with Eimeria spp. Besides, higher NP doses numerically improved villi height in the intestine. In summary, NP was not able to maintain growth performance of birds but presented positive outcomes on nutrient digestibility and reduced oocysts shedding during mixed Eimeria infection.

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Section: Introductionmentioning

confidence: 99%

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

et al. 2020

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“…Some cinnamic acid derivatives are reported to demonstrate a superior antimicrobial activity to that of cinnamic acid itself [5,6]. Pharmaceutical active ingredients containing the nitro group in their structure constitute a vast family with diverse pharmacological effects [7]. In aromatic compounds, a nitro group has a strong electron-withdrawing effect on the aromatic π-system, resulting in deactivation of the ring towards electrophilic aromatic substitutions [8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Crystal Structure of N-(3-nitrophenyl)cinnamamide

et al. 2019

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N-(3-nitrophenyl)cinnamamide 1 with formula C15H12N2O3 was synthesized, and its crystal structure was determined by single-crystal X-ray diffraction analysis. Compound 1 crystallizes in the monoclinic space group P21/n with unit cell dimensions: a = 6.7810 (5) Å, b = 23.0913 (15) Å, c = 8.2079 (5) Å, V = 1282.76 (15) Å3, Z = 4, determined at 150 K with MoKα radiation. The experimental structure refined against atomic scattering factors is compared with the structure obtained using a Hirshfeld Atom Refinement (HAR) approach and Density Functional Theory (DFT) geometry optimizations.

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“…Drugs containing a nitro group are widely used in the treatment of many illnesses and conditions e.g., hypertension, heart failure, coronary artery disease, and in the prevention of stroke [24].…”

Section: Discussionmentioning

confidence: 99%

The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

Żwawiak

Zaprutko

2018

Sci. Pharm.

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Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures.

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Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines

Cited by 78 publications

References 72 publications

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

2-Nitro-1-propanol improved nutrient digestibility and oocyst shedding but not growth performance of Eimeria-challenged broilers

Synthesis, Characterization, and Crystal Structure of N-(3-nitrophenyl)cinnamamide

The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

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