Multidirectional and simultaneous evaluation of gastroschisis-related intestinal damage in chick embryos

Caglar, Muge; Karagüzel, Güngör; Gökhan-Ocak, Güzide Ayşe; Yasar, Duygu; Berker-Karaüzüm, Sibel; Gelen, Tekinalp; Celik, Fatma Nur; Demır, Necdet; Melikoğlu, Mustafa

doi:10.1016/j.jpedsurg.2014.06.019

Cited by 2 publications

(2 citation statements)

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“…This suggests that this delayed release of I-FABP after the small intestine surgery is either caused by protracted stricture of the circulation, which combines higher intestinal damage and delayed I-FABP release, or that it is a result of re-perfusion damage to the intestine [4]. This is in agreement with studies on animal models of GS, showing that increased intra-abdominal pressure leads to gut mucosa damage, possibly via oxidative stress and an increase in apoptotic activity of enterocytes [19, 20].…”

Section: Discussionsupporting

confidence: 81%

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

et al. 2019

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Background/PurposeWe analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery.MethodsIn this prospective study, we collected urine during the first 48h after surgery from neonates operated between 2012 and 2015 for GS. Neonates with surgery that did not include gut mucosa served as controls for simple GS and neonates with surgery for intestinal atresia served as control for complex GS patients. The I-FABP levels were analyzed by ELISA.ResultsUrinary I-FABP after the surgery is significantly higher in GS newborns than in control group; I-FABP in complex GS is higher than in simple GS. I-FABP can predict subsequent operation for ileus in patients with complex GS. Both ways of abdominal wall closure (i.e. primary closure and stepwise reconstruction) led to similar levels of I-FABP. None of the static I-FABP values was useful for the outcome prediction. The steep decrease in I-FABP after the surgery is associated with faster recovery, but it cannot predict early start of minimal enteral feeding, full enteral feeding or length of hospitalization.ConclusionUrinary I-FABP reflects the mucosal damage in gastroschisis but it has only a limited predictive value for patients’ outcome.

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Section: Discussionsupporting

confidence: 81%

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

et al. 2019

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“…These results showed more damage at the epithelial layer and on intramural neural ganglia, associated with a significant downregulation of apoptosis by the nuclear factor family. 47 Ulusoy et al investigated the effects of the lipid or water soluble subfractions of meconium on the intestines and found that the first promotes more DI. The same study was performed measuring the contractility of SMA, and it was found that the water soluble subfractions of meconium promoted vasoconstriction of artery 48,49 (►Table 2).…”

Section: Gastroschisis Model Surgically Created In Chickmentioning

confidence: 99%

Gastroschisis: State of the Art in Translating Experimental Research to the Bedside

et al. 2019

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The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs and fetal therapies in an attempt to reduce the intestinal damage and to provide a rapid return of intestinal motility. Our aim was to describe the main GS models and the translational, historical impact of these research advances on the disease.

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Multidirectional and simultaneous evaluation of gastroschisis-related intestinal damage in chick embryos

Cited by 2 publications

References 47 publications

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

Gastroschisis: State of the Art in Translating Experimental Research to the Bedside

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