Multidimensional visualization for the immune system state presentation in breast cancer patients

Стахеева, М. Н.; Eidenzon, Dmitri; Чердынцева, Н. В.; Slonimskaya, Е. М.; Cherdyntsev, Evgeny

doi:10.1063/1.4936066

Cited by 2 publications

(3 citation statements)

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“…In our previous study, using the integrative approach of multidimensional visualization (NovoSpark Corporation) to portray immune system (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) 28 (28-28) 24 (20-28) 23 (18-30) 25 (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) CD4 + /CD8 + ratio 1.2 (0.9-1.7) 1.2 (0.9-1.7) 1.3 (0.8-1.7) 1.4 (0.7-1.7) 1.2 (0.8-1.9) 0.8 (0.7-0.9) 1.6 (1.0-2.3) 1.2 (0.9-1.8) 1.2 (0.9-1.7) CD56 + NK cells, % 15 (9- Note: *differences are statistically significant in comparison with group without progression, p < 0.05; # differences are statistically significant in comparison with group favorable immune system state, p < 0.05. state as a single visual image [43], we found that the immune system can be reside in at least two differ ent states. One status, which we called as favorable, was observed in BC patients without recurrence, and another status -unfavorable -was associated with relapses in BC patients within 3 year followup pe riod [43]. Existence of different states of an immune system in cancer patients is in concordance with the concept of cancer immunoediting, which postulated immune system ability to protect cancer or, in contrast, to promote tumor growth and progression [47].…”

Section: Discussionmentioning

confidence: 90%

“…In our previous study, we have applied the approach of NovoSpark multidimensional data visualization to generate an integral characteristic of the immune system state, uniting 52 separate immunological pa rameters, in 65 BC patients before treatment [43]. When we analyzed features of a visual curve as an integral characteristic of the immune system for each BC pa tient, we found that its location in multidimensional data space depends on disease outcome followed for 3 years [43]. The obtained data allow us to assume that a unified characteristic of the integral state of the im mune system can have a predictive value for cancer out come.…”

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confidence: 99%

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Integral characteristic of the immune system state predicts breast cancer outcome

Стахеева

Eidenzon²,

Slonimskaya

et al. 2023

Exp. oncol.

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Summary. The immune system dramatically contributes to the pathogenesis of cancer. An integral estimation of immune system state is considered to be perspective as a prognostic criterion for cancer. We hypothesize that the integral characteristic, uniting numerous parameters of immune response to tumor and presenting the state of the immune system of a cancer patient, may be of prognostic significance. The aim of this work was to verify this hypothesis. Materials and Methods: We have evaluated 17 parameters characterizing key innate and adaptive arms of immune system in 146 patients with primary diagnosed local breast cancer (BC) before cancer treatment. Using the original integrative approach of NovoSpark Corporation (Canada), we have presented the state of the immune system by a single visual image for each patient. Results: We classified all BC patients in two groups: with favorable and unfavorable immune system states according to our previous data demonstrating dramatic differences of the visual images of immune system states in patients with good or poor disease outcomes. Then, we have examined the relationship between integral characteristic of the immune system state and the clinical outcome. The 3-year disease-free survival (DFS) of BC patients with favorable immune system state was more than 96.0% vs 65.4% in patients with unfavorable status (p = 0.00006). Univariate Cox proportional hazards regression analysis showed that the integral characteristic of immune system state assessed prior to cancer treatment as unfavorable, was predictive of the poorer DFS (HR = 15.70 [2.15–114.90], p = 0.0007). Conclusion: The integral characteristic of the immune system state is a significant prognostic factor in BC patients. The BC patients with favorable integral immune system state can be considered as a target group for immunotherapeutic approach.

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Section: Discussionmentioning

confidence: 90%

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confidence: 99%

Integral characteristic of the immune system state predicts breast cancer outcome

Стахеева

Eidenzon²,

Slonimskaya

et al. 2023

Exp. oncol.

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“…Visualization of the state of the immune system in metastatic melanoma patients with different responses to vaccine therapy Visualization of the immune system state as a multidimensional observation makes it possible to demonstrate a qualitative difference in the immunological status in cancer patients [7,[12][13][14]. It is important that this methodological approach allows identification of immunological parameters that are statistically significant for discrimination of the immune system state in groups with various clinical manifestations.…”

Section: State Of the Immune System In Melanoma Patients With Differe...mentioning

confidence: 99%

The immune system contributes to the effectiveness of vaccine therapy in patients with metastatic melanoma

et al. 2023

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The aim of the study was to identify differences in the immune system parameters between metastatic melanoma patients who responded and did not respond to dendritic cell vaccination.Material and Methods. The study group included 20 patients with stage III–IV metastatic melanoma, who received vaccine therapy with dendritic cells (DC) in a prophylactic mode. The control groups included 13 patients who had symptoms of disease progression at the time of starting vaccine therapy, and 5 healthy donors. The DC-vaccine was prepared in the form of a suspension of the patient’s autologous dendritic cells loaded with tumor antigens in vitro. A single dose had 2 million dendritic cells in 1 ml of phosphate buffer solution, which was administered intradermally in the nearest site to the regional lymphatic collectors. The immune system status was assessed before starting vaccination. The immune system status was evaluated according to the indices of 25 peripheral blood cell populations using multicolor flow cytometry and integral characteristic in the form of the visual image generated by the visualization method of multidimensional data (NovoSpark, Canada).Results. The immune status in patients with metastatic melanoma at the start of DC-vaccination differed and was associated with the effectiveness of subsequent vaccine therapy. The response to vaccination was observed in patients whose immune system status was similar to that of healthy individuals. Low efficacy of DC-vaccine therapy was shown in patients whose immune system status corresponded to that of patients with disease progression. Alterations of the immune system in patients with metastatic melanoma were registered both at the level of individual immunological parameters and at the level of visualized integral characteristics. The integral characteristics of the immune system associated with the patient’s immunocompromised status can be considered as a criterion for stratification of patients with metastatic melanoma for the effective DC-vaccine therapy.Conclusion. The effectiveness of vaccine therapy with dendritic cells in patients with metastatic melanoma is associated with the immune system state before starting this therapy.

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Multidimensional visualization for the immune system state presentation in breast cancer patients

Cited by 2 publications

References 3 publications

Integral characteristic of the immune system state predicts breast cancer outcome

Integral characteristic of the immune system state predicts breast cancer outcome

The immune system contributes to the effectiveness of vaccine therapy in patients with metastatic melanoma

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