Multidimensional gas chromatography using microfluidic switching and low thermal mass gas chromatography for the characterization of targeted volatile organic compounds

Luong, Jim; Gras, Ronda; Hawryluk, Myron; Shellie, Robert A.; Cortes, Hernan J.

doi:10.1016/j.chroma.2013.02.084

Cited by 13 publications

(12 citation statements)

References 21 publications

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“…Biosensor is a newly developed and promising analytical technique for preservatives, but this technique can only detect organophosphorous preservatives [10]. GC and GC-MS suit for volatile preservatives [20,21]. ELISA, CE and other detection instruments can not be compared with ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in many fields such as sensitivity, application range and so on.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of 18 preservative residues in vegetables by ultra high performance liquid chromatography coupled with triple quadrupole/linear ion trap mass spectrometry using a dispersive-SPE procedure

Zhou

Cao

et al. 2015

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of 18 preservative residues in vegetables by ultra high performance liquid chromatography coupled with triple quadrupole/linear ion trap mass spectrometry using a dispersive-SPE procedure

Zhou

Cao

et al. 2015

Journal of Chromatography B

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“…In fact, the performance of the modulator speaks to the need to improve the performance of GC so much more efficient 1 D separations are achieved, such as providing 1 w b of ∼200−400 ms concurrently with a P M of ∼100 ms, so the sampling density is more appropriate. Recent advances in GC technology have been very promising in this regard, 29,30 such as resistively heated temperature programming, 27,31,32 with extension to micro-GC formats. 33−35 Developments in axial thermal gradient GC 36 and flow field thermal gradient GC 37 are also very promising platforms for potential integration with pulse flow valve modulation.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Development of Ultrafast Separations Using Negative Pulse Partial Modulation To Enable New Directions in Gas Chromatography

et al. 2019

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Partial modulation via a pulse flow valve operated in the negative pulse mode is developed for highspeed one-dimensional gas chromatography (1D-GC), comprehensive two-dimensional (2D) gas chromatography (GC × GC), and comprehensive three-dimensional gas chromatography (GC 3 ). The pulse flow valve readily provides very short modulation periods, P M , demonstrated herein at 100, 200, and 300 ms, and holds significant promise to increase the scope and applicability of GC instrumentation. The negative pulse mode creates an extremely narrow, local analyte concentration pulse. The reproducibility of the negative pulse mode is validated in a 1D-GC mode, where a pseudosteady-state analyte stream is modulated, and 8 analytes are baseline resolved (resolution, R s ≥ 1.5) in a 200 ms window, providing a peak capacity, n c , of 14 at unit resolution (R s = 1.0). Additionally, the pulse width, p w , of the pulse flow valve "injection" relationship to peak width-at-base, w b , resolution between peaks and detection sensitivity are studied. To demonstrate the applicability to GC × GC, a high-speed separation of a 20-component test mixture of similar, volatile analytes is shown. Analytes were separated on the second-dimension column, 2 D, with 2 w b ranging from 7 to 12 ms, providing an exceptional 2 D peak capacity, 2 n c , of ∼12 using a modulation period (P M ) of 100 ms. Next, a 12 min separation of a diesel sample using a P M of 300 ms is presented. The 1 w b is ∼4 s, resulting in a 1 n c of ∼180, and 2 w b is ∼18 ms, resulting in a 2 n c of ∼17, thus achieving a n c,2D of ∼3000 in this rapid GC × GC diesel separation. Finally, GC 3 with time-of-flight mass spectrometry (TOFMS) detection using a P M of 100 ms applied between the 2 D and 3 D columns is reported. Narrow third dimension, 3 D, peaks with 3 w b of ∼15 ms were obtained, resulting in a GC 3 peak capacity, n c,3D , of ∼35 000 in a 45 min separation.

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“…Other techniques for rapid column heating, such as thermal gradient chromatography [20][21][22][23] have shown promise as novel technologies in the fast GC field. The results we present herein, as well as the results presented in previous references have important implications for two-dimensional gas chromatography (GC × GC or GC-GC) [24][25][26]. Consideration of separation times, peak widths, flow rates, heating rates, and other instrumental parameters must be implemented in a way that adequately preserves the two-dimensionality of the data that make GC × GC and GC-GC such powerful techniques.…”

Section: Introductionmentioning

confidence: 88%

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography

Fitz

Mannion

et al. 2015

Journal of Chromatography A

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Multidimensional gas chromatography using microfluidic switching and low thermal mass gas chromatography for the characterization of targeted volatile organic compounds

Cited by 13 publications

References 21 publications

Simultaneous determination of 18 preservative residues in vegetables by ultra high performance liquid chromatography coupled with triple quadrupole/linear ion trap mass spectrometry using a dispersive-SPE procedure

Simultaneous determination of 18 preservative residues in vegetables by ultra high performance liquid chromatography coupled with triple quadrupole/linear ion trap mass spectrometry using a dispersive-SPE procedure

Development of Ultrafast Separations Using Negative Pulse Partial Modulation To Enable New Directions in Gas Chromatography

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography

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