Multidimensional futuristic approaches to address the pandemics beyond COVID-19

Kotwal, Shifa Bushra; Orekondey, Nidhi; Saradadevi, Gargi Prasad; Priyadarshini, Neha; Puppala, Navinchandra V.; Bhushan, Mahak; Motamarry, Snehasri; Kumar, Rahul; Mohannath, Gireesha; Dey, Ruchi Jain

doi:10.1016/j.heliyon.2023.e17148

Cited by 4 publications

(4 citation statements)

References 294 publications

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“…VLP vaccines have been shown to be much more effective than subunit vaccines, which are a similar technology, in terms of stimulating the immune system . VLPs mimic infection more successfully in terms of cellular uptake, and since they contain many different viral antigenic structures, they can create a high level of antibody response against different epitopes and also trigger cellular immunity. ,,− However, the disadvantages of this system are the complexity in its production, high production cost, stability problems, and the difficulty of creating a VLP structure. , Nevertheless, due to the superior advantages it provides, the VLP vaccine platform has become a highly preferred technology, especially among vaccine candidates developed or under development against Covid-19. ,, In this respect, there are many VLP Covid-19 vaccine candidates in approval process and among these, only plant-based Covifenz has been approved for use in Canada. , Additionally, there are currently commercial VLP vaccines developed against human papillomavirus (HPV) and hepatitis B virus. − …”

Section: Currently Available Viral Vaccine Typesmentioning

confidence: 99%

“… 21 , 39 , 40 In this respect, there are many VLP Covid-19 vaccine candidates in approval process and among these, only plant-based Covifenz has been approved for use in Canada. 20 , 42 Additionally, there are currently commercial VLP vaccines developed against human papillomavirus (HPV) and hepatitis B virus. 39 − 41 …”

Section: Currently Available Viral Vaccine Typesmentioning

confidence: 99%

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Animal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspective

Demirden,

Kimiz-Gebologlu,

Oncel

2024

ACS Omega

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Vaccines are considered the most effective tools for preventing diseases. In this sense, with the Covid-19 pandemic, the effects of which continue all over the world, humanity has once again remembered the importance of the vaccine. Also, with the various epidemic outbreaks that occurred previously, the development processes of effective vaccines against these viral pathogens have accelerated. By these efforts, many different new vaccine platforms have been approved for commercial use and have been introduced to the commercial landscape. In addition, innovations have been made in the production processes carried out with conventionally produced vaccine types to create a rapid response to prevent potential epidemics or pandemics. In this situation, various cell lines are being positioned at the center of the production processes of these new generation viral vaccines as expression platforms. Therefore, since the main goal is to produce a fast, safe, and effective vaccine to prevent the disease, in addition to existing expression systems, different cell lines that have not been used in vaccine production until now have been included in commercial production for the first time. In this review, first current viral vaccine types in clinical use today are described. Then, the reason for using cell lines, which are the expression platforms used in the production of these viral vaccines, and the general production processes of cell culture-based viral vaccines are mentioned. Also, selection parameters for animal cell lines as expression platforms in vaccine production are explained by considering bioprocess efficiency and current regulations. Finally, all different cell lines used in cell culture-based viral vaccine production and their properties are summarized, with an emphasis on the current and future status of cell cultures in industrial viral vaccine production.

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Section: Currently Available Viral Vaccine Typesmentioning

confidence: 99%

Section: Currently Available Viral Vaccine Typesmentioning

confidence: 99%

Animal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspective

Demirden,

Kimiz-Gebologlu,

Oncel

2024

ACS Omega

View full text Add to dashboard Cite

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“…[33][34][35][36][37][38] Plant-based expression system also provides a high level of safety and can facilitate regulatory approvals without costly infrastructure. 39,40 Proteins expressed from the chloroplast genome can retain their structure and function at room temperature, enabling long-term Plasma B cells produce specific neutralizing antibodies aimed at eliminating the virus storage in non-refrigerated environments. 41 Compared with inactivated viruses, subunit protein vaccines use specific immunogenic epitopes, eliciting more robust immune responses and neutralizing antibodies.…”

Section: Current Covid-19 Preventive and Therapeutic Strategies Curre...mentioning

confidence: 99%

“…3). 39,131 Small molecule-based inhibitors papain-like protease (PL-pro) instead of M-pro can also target other vital proteases in virus replication. 132,133 siRNA acts directly and specifically on viral RNA, reducing the risk of drug resistance and improving drug safety.…”

Section: Current Covid-19 Preventive and Therapeutic Strategies Curre...mentioning

confidence: 99%

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

Ao,

He,

Liu

et al. 2023

Sig Transduct Target Ther

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The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and social unrest. In response, various prevention and control strategies have been implemented globally, including vaccine and drug development and the promotion of preventive measures. Implementing these strategies has effectively curbed the transmission of the virus, reduced infection rates, and gradually restored normal social and economic activities. However, the mutations of SARS-CoV-2 have led to inevitable infections and reinfections, and the number of deaths continues to rise. Therefore, there is still a need to improve existing prevention and control strategies, mainly focusing on developing novel vaccines and drugs, expediting medical authorization processes, and keeping epidemic surveillance. These measures are crucial to combat the Coronavirus disease (COVID-19) pandemic and achieve sustained, long-term prevention, management, and disease control. Here, we summarized the characteristics of existing COVID-19 vaccines and drugs and suggested potential future directions for their development. Furthermore, we discussed the COVID-19-related policies implemented over the past years and presented some strategies for the future.

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Severity-onset prediction of COVID-19 via artificial-intelligence analysis of multivariate factors

Fu¹,

Zeng²,

Huang³

et al. 2023

Heliyon

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Multidimensional futuristic approaches to address the pandemics beyond COVID-19

Cited by 4 publications

References 294 publications

Animal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspective

Animal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspective

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

Severity-onset prediction of COVID-19 via artificial-intelligence analysis of multivariate factors

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