Multidimensional engineering of Saccharomyces cerevisiae for improved vanillin synthesis
Qiwen Mo,
Jifeng Yuan
Abstract:Background Vanillin represents one of the most widely used flavoring agents in the world. However, microbial synthesis of vanillin is hindered by the host native metabolism that could rapidly degrade vanillin to the byproducts.
Results Here, we report that the industrial workhorse Saccharomyces cerevisiae was engineered by systematic deletion of oxidoreductases to improve the vanillin accumulation. Subsequently, we harnessed the reduced aromatic aldehyde reduction (RARE) yeast platform for de novo synthesis of… Show more
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