Smart Specialisation is dedicated to be a key driving force for entrepreneurial discovery and innovation in the European innovation policy paradigm in line with the European Strategy 2020 and the funding period 2014-2020. At the current stage, all EU NUTS-2 regions are monitoring their individually developed Regional Innovation Strategies on Smart Specialisation (RIS3) including monitoring systems that are needed to adjust upcoming future RIS3 strategies in the new funding periods. Despite the thematic topicality, the procedure of RIS3 evaluation and monitoring lacks a sound supra-regional approach when it comes to RIS3 implementation performance governance and institutional arrangements across all European regions. In fact, the blurring of RIS3 monitoring can be traced back to the policy nature that monitoring systems are set up, implemented and evaluated on individual regional and or national basis including a set of regionally tailored regional and national indicators. With regard to the policy challenges and research gaps of developing, and, later, using a joint macro-regional systemic institutional approach towards RIS3 implementation and monitoring, this paper provides a conceptual model for RIS3 performance, evaluation and monitoring governance based on case study analysis, best practices from RIS3 research and policy stakeholders' interviews. It is intended to serve as a comprehensive and comparative governance model on regional, national and * This research was supported by the EU project "SMART_watch", part-financed by the European Regional Development Fund (ERDF) within the INTERREG Central Europe Programme 2014 -2020. The project is dedicated to foster the cooperation between the Regional Innovation Strategies on Smart Specialisation (RIS3) monitoring and the actual needs of the implementing regional stakeholders.