Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer

Guo, Yu; Shi, Jian; Zhao, Zeyun; Wang, Min

doi:10.2147/ijgm.s337876

Cited by 10 publications

(8 citation statements)

References 38 publications

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“…Charged multivesicular body protein 7 (CHMP7) forms a complex with ESCRT III in the ESCRT system, and initiates the degradation of cell surface receptors ( 40 , 41 ). In addition, CHMP7 is highly expressed in certain hematological malignancies, which is consistent with our research ( 42 ). Cytochrome c somatic (CYCS) is associated with mitochondrial dysfunction and autophagy defects, and it also has potential mechanism in tumor cell proliferation and apoptosis ( 43 , 44 ).…”

Section: Discussionsupporting

confidence: 92%

Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma

Wang

Shao

et al. 2022

Front. Oncol.

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PurposePyroptosis is an inflammation-based programmed cell death that holds great potential as a novel cancer therapeutic target in patients with multiple myeloma (MM). However, thus far, the function of pyroptosis-related genes (PRGs) in MM and their prognostic relevance remains undetermined.MethodsThe model was established by the LASSO analysis, based on the Gene Expression Omnibus (GEO) dabatase, and its efficacy was verified using two external datasets. The model’s predictive ability was assessed by the Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) curves. Finally, a nomogram was established for clinical application. We also confirmed the validity of our model using specimens and in vitro experiments.ResultsWe established an 11-PRG signature profile, and verified its efficacy using two validation cohorts (VCs). In both cohorts, patients were separated into two subpopulations, according to their median risk scores (RS). Our analysis revealed that high-risk (HR) patients experienced considerably lower overall survival (OS), compared to the low-risk (LR) patients. Using functional enrichment and immune infiltration analyses, we demonstrated that the immunologic status was strongly related to RS. Furthermore, using a pyroptosis inhibitor Q-VD-OPh, we revealed that MM cell proliferation and progression was drastically suppressed and the doxorubicin (DOX)-induced apoptosis was reversed.ConclusionBased on our analysis, pyroptosis not only serves as a measure of MM treatment efficiency and patient prognosis, but is also a possible target for anti-MM therapy.

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Section: Discussionsupporting

confidence: 92%

Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma

Wang

Shao

et al. 2022

Front. Oncol.

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“…40 According to a study, CHMP7 interacts with invading immune cells in the tumor microenvironment and has reduced expression in a variety of tumors compared to normal tissue, which may be a factor in cancer patients' poor prognoses. 41 A member of the GSDM family, GSDMB, can induce pyroptosis by being cleaved by caspase-1/3/4/5/6/7/11; however, further research is needed to determine the precise mechanism by which GSDMB is cleaved by caspase-3/6/7 and engaged in pyroptosis. 15,16,42 According to previous studies, GSDMB is located in genomic regions that are frequently amplified during cancer development and is highly expressed in a variety of cancer tissues, such as cervical, gastric, pancreatic and breast cancers, amongst others.…”

Section: Discussionmentioning

confidence: 99%

“…Contraction, shearing necking and ultimate membrane shedding can all be accomplished with the help of CHMP7, which is essential for the endosomal sorting pathway 40 . According to a study, CHMP7 interacts with invading immune cells in the tumor microenvironment and has reduced expression in a variety of tumors compared to normal tissue, which may be a factor in cancer patients' poor prognoses 41 . A member of the GSDM family, GSDMB, can induce pyroptosis by being cleaved by caspase‐1/3/4/5/6/7/11; however, further research is needed to determine the precise mechanism by which GSDMB is cleaved by caspase‐3/6/7 and engaged in pyroptosis 15,16,42 .…”

Section: Discussionmentioning

confidence: 99%

Relevance of pyroptosis‐associated genes in nasopharyngeal carcinoma diagnosis and subtype classification

Wang,

Zou,

Chen

et al. 2024

The Journal of Gene Medicine

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BackgroundNasopharyngeal carcinoma (NPC) is a highly aggressive and metastatic malignancy originating in the nasopharyngeal tissue. Pyroptosis is a relatively newly discovered, regulated form of necrotic cell death induced by inflammatory caspases that is associated with a variety of diseases. However, the role and mechanism of pyroptosis in NPC are not fully understood.MethodsWe analyzed the differential expression of pyroptosis‐related genes (PRGs) between patients with and without NPC from the GSE53819 and GSE64634 datasets of the Gene Expression Omnibus (GEO) database. We mapped receptor operating characteristic profiles for these key PRGs to assess the accuracy of the genes for disease diagnosis and prediction of patient prognosis. In addition, we constructed a nomogram based on these key PRGs and carried out a decision curve analysis. The NPC patients were classified into different pyroptosis gene clusters by the consensus clustering method based on key PRGs, whereas the expression profiles of the key PRGs were analyzed by applying principal component analysis. We also analyzed the differences in key PRGs, immune cell infiltration and NPC‐related genes between the clusters. Finally, we performed differential expression analysis for pyroptosis clusters and obtained differentially expressed genes (DEGs) and performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses.ResultsWe obtained 14 differentially expressed PRGs from GEO database. Based on these 14 differentially expressed PRGs, we applied least absolute shrinkage and selection operator analysis and the random forest algorithm to obtain four key PRGs (CHMP7, IL1A, TP63 and GSDMB). We completely distinguished the NPC patients into two pyroptosis gene clusters (pyroptosis clusters A and B) based on four key PRGs. Furthermore, we determined the immune cell abundance of each NPC sample, estimated the association between the four PRGs and immune cells, and determined the difference in immune cell infiltration between the two pyroptosis gene clusters. Finally, we obtained and functional enrichment analyses 259 DEGs by differential expression analysis for both pyroptosis clusters.ConclusionsPRGs are critical in the development of NPC, and our research on the pyroptosis gene cluster may help direct future NPC therapeutic approaches.

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“…MAPK9 belongs to the MAPK pathway, it has been reported that genetic variation in the MAPK signaling pathway genes can mediate cell proliferation and migration of colorectal cancer cells ( Schwartsmann et al, 2005 ). CHMP7 plays a significant role in the endosomal sorting pathway, and the deficient expression of CHMP7 in the majority of tumor tissues has been reported ( Guo Y. et al, 2021 ). However, the role of CHMP2B, BID and CHMP6 in colorectal cancer have not been reported yet, which may provide new biomarkers for future research on the relationship between necrosis and colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Necroptosis-Related Genes Associated With Immune Activity and Prognosis of Colorectal Cancer

Peng

Guo

et al. 2022

Front. Genet.

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This study aims at screening out the key necroptosis-related genes in colorectal cancer and elucidating the role of necroptosis-related genes in the immune activity and prognosis of colorectal cancer (CRC). The CRC patients’ data were downloaded from The Cancer Genome Atlas (TCGA). The non-negative matrix factorization method was applied to identify new molecular subgroups. Survival analysis and single sample Gene Set Enrichment Analysis were performed to determinate the differences in the overall survival time and immune status of the subgroups. Prognostic model was constructed on the basis of univariate Cox regression and LASSO analysis. Functional analyses were used to explore the potential mechanisms. Based on prognostic related necroptosis genes, we identify two molecular subgroups with significantly different survival. The better prognosis was associated with more active immune infiltration and upregulated expression of immune checkpoints. We screened nine necroptosis related genes as key prognostic genes and established a risk model, which showed a good potential for survival prediction in colorectal cancer. Nomogram assessment showed that the model had high reliability for predicting the prognosis of colorectal cancer patients. The high-risk and low-risk group also has different sensitivity to immunotherapy and commonly used drugs for colorectal cancer. Overall, necroptosis related genes were involved in the immune microenvironment of colorectal cancer patient, could be utilized to predict the prognosis of colorectal cancer and develop more individualized treatment.

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Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer

Cited by 10 publications

References 38 publications

Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma

Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma

Relevance of pyroptosis‐associated genes in nasopharyngeal carcinoma diagnosis and subtype classification

Necroptosis-Related Genes Associated With Immune Activity and Prognosis of Colorectal Cancer

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