Multidex gel for use in wound care

McFadden, Ellen A.

doi:10.1016/s0882-5963(97)80037-1

Cited by 6 publications

(6 citation statements)

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“…However, the benefit of maltodextrin for wound healing and its mechanisms have been described. [20][21][22][23] MD is a mixture of monosaccharides and polysaccharides. Effectively, MD serves as a chemotactant for white blood cells, macrophages, and fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

et al. 2014

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BACKGROUND: Tracheostomy wounds are commonly encountered in children but rarely reported. Relatively few treatments are available or have been investigated to manage this problem. Healing times for pediatric tracheostomy wounds are often unpredictable and protracted. Recent use of maltodextrin gel (MD) and a silver alginate sponge (AG) at our institution has demonstrated expedited healing and interest in this novel treatment for tracheostomy wounds. METHODS: We conducted an 11-month retrospective review of children with wound complications following tracheostomy placement at a tertiary care facility. Wounds were evaluated and rated based upon the National Pressure Ulcer Advisory Panel staging system. Subjects identified with stage 2 or greater tracheostomy-related ulcers treated with MD and/or AG were included. Subject characteristics and wound healing rates were tabulated in a database that included age, wound site, initial and final wound stage, type of treatment, length of treatment, and complications. Tracheostomy wounds treated as an out-patient were excluded from the study. RESULTS: Eighteen subjects, which included both in-patients and out-patients, were treated with AG and/or MD during the study period for tracheostomy-related wounds. Of the 26 subjects with tracheostomies performed during the study period, 10 (38.5%) were treated for postoperative wounds. A total of 11 subjects completed their in-patient wound treatment and were thus included in the study. Average subject age was 5.3 y (range 0.25-15.6 y). Wound locations were as follows: infrastomal region (n ‫؍‬ 8), stoma (n ‫؍‬ 2), and lateral neck (n ‫؍‬ 1). Six subjects had stage 2 wounds, 4 had stage 3 wounds, and 1 had a stage 4 ulcer. All wounds achieved complete epithelialization following treatment with MD and/or AG. The average length of treatment was 12.8 d (range 6 -28 d). No adverse effects were identified. CONCLUSIONS: Postoperative tracheostomy wounds are common. The use of MD and AG provides an effective and safe treatment for tracheostomy-related ulcers.

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Section: Discussionmentioning

confidence: 99%

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

et al. 2014

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“…[16][17][18] Their most important features are designed to allow excess fluid to be lost by water vapor transmission through the membrane but prevent dehydration of the wound, thus providing an environment for moist wound healing. 19 Film dressings are well suited for superficial wounds, but a lack of absorbing capacity and impermeability to water vapor and gases cause the accumulation of wound fluid beneath the dressing and hence allow the leakage of exudates and the entry of exogenous bacterial to the wound surface. If the exudates that are produced exceed the water vapor transmission rate (WVTR), the dressing becomes plugged, and fluid will accumulate underneath the dressing, making is less effective.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of waterborne polyurethane/poly(N‐vinylpyrrolidone) composite films for wound‐healing dressings

Yoo

Kim

2007

J of Applied Polymer Sci

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For ideal wound-healing dressings, a series of waterborne polyurethane (WBPU)/poly(N-vinylpyrrolidone) (PVP) composite films (transparent film dressings) were prepared by in situ polymerization in an aqueous medium. Stable WBPU/PVP composites, which had a high remaining weight greater than 98.4%, were obtained. The maximum content of PVP for stable WBPU/PVP dispersions was found to be about 15 wt %. The water absorption (%) and equilibrium water content (%) of the WBPU/ PVP composite films remarkably increased in proportion to the PVP content and the time of water immersion. The maximum water absorption and equilibrium water content of the WBPU/PVP composite films were in the range of 21-158 and 22-56%, respectively. The water vapor transmission rate of the WBPU/PVP composite films was in the range of 1816-2728 g/m 2 /day. These results suggest that WBPU/PVP composite films may have high potential as new wound-dressing materials that provide and maintain the moist environment needed to prevent scab formation and dehydration of the wound bed. By a wound-healing evaluation using a full-thickness rat model experiment, it was found that a wound covered with a typical WBPU/ PVP composite film (15 wt % PVP) was completely filled with new epithelium without any significant adverse reactions.

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“…In practice, the e-scaffold can be overlaid onto a biofilm-infected wound in conjunction with a maltodextrin gel or solution. Such treatment can eliminate biofilms while helping to maintain an environment favorable for wound healing5270. Overall, our proposed technology offers enhanced effectiveness in biofilm-infected wound treatment.…”

Section: Discussionmentioning

confidence: 98%

“…We previously demonstrated that an e-scaffold generates a low concentration of H 2 O 2 that can be an effective, nontoxic alternate treatment for biofilm-infected wounds10. Maltodextrin benefits wound healing by promoting collagen formation, granulation tissue growth and epithelial proliferation52697071. The combination of an e-scaffold and maltodextrin clearly enhances the elimination of biofilms of two nosocomial infectious agents, Gram-negative A. baumannii and Gram-positive S. aureus .…”

Section: Discussionmentioning

confidence: 99%

Maltodextrin enhances biofilm elimination by electrochemical scaffold

Sultana

Call

Beyenal

2016

Sci Rep

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Electrochemical scaffolds (e-scaffolds) continuously generate low concentrations of H2O2 suitable for damaging wound biofilms without damaging host tissue. Nevertheless, retarded diffusion combined with H2O2 degradation can limit the efficacy of this potentially important clinical tool. H2O2 diffusion into biofilms and bacterial cells can be increased by damaging the biofilm structure or by activating membrane transportation channels by exposure to hyperosmotic agents. We hypothesized that e-scaffolds would be more effective against Acinetobacter baumannii and Staphylococcus aureus biofilms in the presence of a hyperosmotic agent. E-scaffolds polarized at −600 mVAg/AgCl were overlaid onto preformed biofilms in media containing various maltodextrin concentrations. E-scaffold alone decreased A. baumannii and S. aureus biofilm cell densities by (3.92 ± 0.15) log and (2.31 ± 0.12) log, respectively. Compared to untreated biofilms, the efficacy of the e-scaffold increased to a maximum (8.27 ± 0.05) log reduction in A. baumannii and (4.71 ± 0.12) log reduction in S. aureus biofilm cell densities upon 10 mM and 30 mM maltodextrin addition, respectively. Overall ~55% decrease in relative biofilm surface coverage was achieved for both species. We conclude that combined treatment with electrochemically generated H2O2 from an e-scaffold and maltodextrin is more effective in decreasing viable biofilm cell density.

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Multidex gel for use in wound care

Cited by 6 publications

References 0 publications

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

Characteristics of waterborne polyurethane/poly(N‐vinylpyrrolidone) composite films for wound‐healing dressings

Maltodextrin enhances biofilm elimination by electrochemical scaffold

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