Multidetector CT imaging features of invasive renal parenchyma urothelial carcinoma

Zhu, Qi; Zhu, Wei; Wu, Jingtao; Chen, Wenxin

doi:10.1259/bjr.20151068

Cited by 9 publications

(14 citation statements)

References 26 publications

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“…Previous reports of the CT features of RUC did not include flowcharts depicting the selection of the patients. 9,10,35 The description and characteristics of ERUC cases in the present study differed in certain ways from those in previous studies. In the present ERUC cases, renal calculi and hydronephrosis were recorded, which were not mentioned in 3 previous reports, 9,10,35 and were reported only as unusual imaging manifestations by Prando et al 36 Zhu et al 35 reported a few RUCs with necrosis, whereas Raza et al 9 did not mention the number of necrosis.…”

Section: Discussioncontrasting

confidence: 74%

“…9,10,35 The description and characteristics of ERUC cases in the present study differed in certain ways from those in previous studies. In the present ERUC cases, renal calculi and hydronephrosis were recorded, which were not mentioned in 3 previous reports, 9,10,35 and were reported only as unusual imaging manifestations by Prando et al 36 Zhu et al 35 reported a few RUCs with necrosis, whereas Raza et al 9 did not mention the number of necrosis. Moreover, we observed higher incidence of flank pain and hematuria in the present cases of ERUC as compared to that of previous reports.…”

Section: Discussioncontrasting

confidence: 74%

See 1 more Smart Citation

CT and clinical features for distinguishing endophytic clear cell renal cell carcinoma from urothelial carcinoma

Chen¹,

Chen²,

Leia³

et al. 2022

Diagn Interv Radiol

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Section: Discussioncontrasting

confidence: 74%

Section: Discussioncontrasting

confidence: 74%

CT and clinical features for distinguishing endophytic clear cell renal cell carcinoma from urothelial carcinoma

Chen¹,

Chen²,

Leia³

et al. 2022

Diagn Interv Radiol

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“…5 a-d). These results were consistent with previous reports [ 12 , 18 , 19 ]. The cyst-solid lesions were found uncommon in both RUC and ccRCC.…”

Section: Discussionsupporting

confidence: 94%

“…Neither Raza nor Bata et al determined the correlation between clinical data and CT in identifying RUC and ccRCC [ 12 , 13 ]. Zhu and Ding et al only described the clinical and CT features of RUC without comparing RUC and RCC [ 18 , 19 ]. Clinical characteristics have yielded reference value for diagnosis, such as smoking history, presence of nephrolith, hematuria, and flank pain [ 20 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

CT findings and clinical characteristics in distinguishing renal urothelial carcinoma mimicking renal cell carcinoma from clear cell renal cell carcinoma

Chen,

Feng,

Chen

et al. 2024

BMC Urol

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Background We aimed to characterize the clinical and multiphase computed tomography (CT) features, which can distinguish renal urothelial carcinoma (RUC) mimicking renal cell carcinoma (RCC) from clear cell renal cell carcinoma (ccRCC) with collecting system invasion (CSI). Methods Data from 56 patients with RUC (46 men and 10 women) and 366 patients with ccRCC (262 men and 104 women) were collected and assessed retrospectively. The median age was 65.50 (IQR: 56.25–69.75) and 53.50 (IQR: 42.25–62.5) years, respectively. Univariate and multivariate logistic regression analyses were performed on clinical and CT characteristics to determine independent factors for distinguishing RUC and ccRCC, and an integrated predictive model was constructed. Differential diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUC). Results The independent predictors for differentiating RUC from ccRCC were infiltrative growth pattern, hydronephrosis, heterogeneous enhancement, preserving reniform contour, and hematuria. The differential diagnostic performance of the integrated predictive model-1 (AUC: 0.947, sensitivity: 89.07%, specificity: 89.29%) and model-2 (AUC: 0.960, sensitivity: 92.1%, specificity: 89.3%) were both better than that of the infiltrative growth pattern (AUC: 0.830, sensitivity: 71.9%, specificity: 92.9%), heterogeneous enhancement (AUC: 0.771, sensitivity: 86.3%, specificity: 67.9%), preserving reniform contour (AUC = 0.758, sensitivity: 85.5%, specificity: 66.1%), hydronephrosis (AUC: 0.733, sensitivity: 87.7%, specificity: 58.9%), or hematuria (AUC: 0.706, sensitivity: 79.5%, specificity: 51.8%). Conclusion The CT and clinical characteristics showed extraordinary discriminative abilities in the differential diagnosis of RUC and ccRCC, which might provide helpful information for clinical decision-making.

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“…There was no obvious tendency about sex. Zhu et al (16) retrospectively assessed 29 patients with invasive renal parenchymal urothelial carcinoma (IRPUC) and found that IRPUC was more likely to occur in the right kidney (82.7%). However, in the present study, the ratio of malignancies in left and right kidneys was 11 vs. 10.…”

Section: Discussionmentioning

confidence: 99%

Intrarenal urothelial cancers confused as infiltrative renal masses: Report of 22�cases and literature review

Ding

Jia

et al. 2018

Oncol Lett

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Distinguishing infiltrative renal masses (IRMs) from intrarenal urothelial cancers (IUCs) is critically important, but may be challenging for any radiologist or urologist. The present study aimed to summarize the clinical, imaging and pathological characteristics of IRM, which were postoperatively confirmed as IUC. The analysis was performed using the records of 22 patients who were preoperatively diagnosed with IRM but the results of percutaneous biopsies or postoperative pathological analyses led to diagnoses of urothelial cancers (UCs) from January 2011 to December 2017. The demographic data, computed tomography (CT) imaging features and pathological characteristics were evaluated. The present study also reviewed the literature concerning the IRM and IUC. The mean age of patients was 62 years and 86.4% of them were >55 years. The sex and tumor side distributions were equal. Hematuria and/or flank pain were observed in 86.4% of patients. All patients exhibited endophytic solid renal masses with unclear tumor boundaries on CT images. The kidneys of 81.8% of patients maintained their normal shape while mild alternations were observed in 18.2% of cases. A total of 81.8% of patients maintained the reniform shape and 18.2% exhibited mild contour change. Of all patients, all tumors exhibited less or equal attenuation on unenhanced CT images and they were mildlyimproved on enhanced CT. A total of 6 cases were confirmed by biopsy, when patients underwent laparoscopic nephroureterectomy instead of radical nephrectomy. The remaining 16 patients underwent laparoscopic nephrectomy but the postoperative pathological diagnoses revealed the presence of UCs. All postoperatively confirmed cancers were stages T3 and T4 (62.5 and 37.5%, respectively). UCs should be suspected in middle aged or elderly middle-elderly patients presenting renal masses with endophytic solid unclear tumor boundary on unenhanced and slightly enhanced CT images, accompanied with hematuria and/or flank pain. Preoperative biopsy is preferred for complicated cases.

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Multidetector CT imaging features of invasive renal parenchyma urothelial carcinoma

Cited by 9 publications

References 26 publications

CT and clinical features for distinguishing endophytic clear cell renal cell carcinoma from urothelial carcinoma

CT and clinical features for distinguishing endophytic clear cell renal cell carcinoma from urothelial carcinoma

CT findings and clinical characteristics in distinguishing renal urothelial carcinoma mimicking renal cell carcinoma from clear cell renal cell carcinoma

Intrarenal urothelial cancers confused as infiltrative renal masses: Report of 22�cases and literature review

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