Multidetector computed tomography aspects of tracheal mucosal leishmaniasis localization

Viglianesi, A.; Mauro, Davide Di; Petrillo, Giuseppe

doi:10.1007/s11604-010-0493-2

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…Other findings include anemia, leucopenia, thrombocytopenia, and hypergammaglobulinemia. Moreover, VL can also manifest itself atypically, mostly in patients infected with HIV, transplants, and elderly immunocompetent patients [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

The Role of F-18 FDG PET in the Diagnosis of Visceral Leishmaniasis: Two Case Reports

Chianura¹,

Ferrari²,

Popescu³

et al. 2014

JCR

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Abstract:Visceral leishmaniasis (VL) is endemic in Mediterranean countries. Among immunosuppressed patients, the disease can manifest with atypical clinical features. An unusual clinical manifestation of the disease is fever of unknown origin (FUO). F-18 fluorodeoxyglucose positron emission tomography-computed tomography (F-18 FDG PET) may be useful for detecting inflammatory foci by observing increased metabolism in activated granulocytes and macrophages. We report two cases of PET/CT total body imaging showing a diffuse increase of reticuloendothelial metabolic activity in the spleen and vertebral bodies in two patients diagnosed with VL by direct detection of amastigotes in bone marrow biopsy.

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Section: Discussionmentioning

confidence: 99%

The Role of F-18 FDG PET in the Diagnosis of Visceral Leishmaniasis: Two Case Reports

Chianura¹,

Ferrari²,

Popescu³

et al. 2014

JCR

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“…Most of the included studies were case reports and one study followed a cross-sectional design. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] The majority of the studies came from India, southern European countries, and Brazil. The studies included 59 patients with a mean age (standard deviation) of 40.3 (±5.9) years, with males predominating (74.5%; 44) and 20% (12) patients co-infected with HIV/AIDS and immunocompromised.…”

Section: Study Characteristics and Patient Demographicsmentioning

confidence: 99%

Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review

Hailemariam,

Mebratu,

Andrias

et al. 2023

SAGE Open Medicine

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Objectives: Visceral leishmaniasis remains a deadly parasitic disease with diagnostic complexities. Currently, point-of-care chest imaging is gaining momentum in the diagnosis of infectious diseases. Respiratory symptoms are common in visceral leishmaniasis. Here we aimed to systematically synthesize the evidence on the utility of chest imaging on the diagnosis and management of patients with visceral leishmaniasis. Methods: We searched PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar databases for studies reporting chest imaging findings in patients with visceral leishmaniasis, published in English from database inception to November 2022. We used the Joanna Briggs Institute checklists to evaluate the risk of bias. The protocol of this systematic review was registered with the Open Science Framework: https://doi.org/10.17605/OSF.IO/XP24W . Results: Of 1792 studies initially retrieved, 17 studies with 59 participants were included. Of the 59 patients, 51% (30) had respiratory symptoms and 20% (12) were human immunodeficiency virus co-infected. Chest X-ray, high-resolution computed tomography, and chest ultrasound findings were available for 95% (56), 93% (55), and 2% (1) of the patients, respectively. The most common findings were pleural effusion (20%; 12), reticular opacities (14%; 8), ground-glass opacities (12%; 7), and mediastinal lymphadenopathies (10%; 6). High-resolution computed tomography was more sensitive than chest X-ray and detected lesions that were lost on chest X-ray, 62% (37) versus 29% (17). In almost all cases, regression of the lesions was observed with treatment. Microscopy of pleural or lung biopsy detected amastigotes. Polymerase chain reaction yield was better in pleural and bronchoalveolar lavage fluids. A parasitological diagnosis from pleural and pericardial fluid was possible in AIDS patients. Overall, the risk of bias was low. Conclusions: Visceral leishmaniasis patients frequently had abnormal findings on high-resolution computed tomography. Chest ultrasound is a useful alternative in resource-limited settings to aid in diagnosis and subsequent treatment follow-up, especially when routine tests yield negative results despite clinical suspicion.

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“…2). This has included the use of computer tomography (CT) scanning to examine tracheal involvement in cutaneous leishmaniasis (Viglianesi et al ., 2011) and identification of nodules in the liver and spleen of visceral leishmaniasis patients (Angarano et al ., 1998; Bukte et al ., 2004). Additionally, radiographic and scintigraphic studies were used to determine the level of bone involvement in a diffuse cutaneous leishmaniasis patient (Costa et al ., 2005).…”

Section: Clinical Imaging and Leishmaniamentioning

confidence: 99%

Leishmania-host interactions: what has imaging taught us?

Beattie

Kaye

2011

Cellular Microbiology

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Leishmania parasites are well adapted to initiate infection, resist the onslaught of innate immunity and achieve a state of long-lived persistence. In recent years, the tools available to study these interactions have developed enormously and have become much more widely available. Confocal microscopy, live cell imaging, whole animal imaging and intra-vital 2-photon now complement and extend the classical light and electron microscopical techniques. Coupled with approaches to generate transgenic parasites that express imaging friendly reporter proteins, these tools are making the full breadth of the life cycle accessible to imaging studies. New insights into the life history of these highly successful parasites are emerging with increasing frequency, and often with startling clarity and visual drama. In this short review, we focus on how this new generation of imaging-based research tools has augmented our understanding of the complex interplay that occurs between Leishmania and the cells that it infects in mammalian hosts.

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Multidetector computed tomography aspects of tracheal mucosal leishmaniasis localization

Cited by 5 publications

References 9 publications

The Role of F-18 FDG PET in the Diagnosis of Visceral Leishmaniasis: Two Case Reports

The Role of F-18 FDG PET in the Diagnosis of Visceral Leishmaniasis: Two Case Reports

Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review

Leishmania-host interactions: what has imaging taught us?

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