Multidetector Computed Tomographic Imaging in Chronic Obstructive Pulmonary Disease

Litmanovich, Diana; Hartwick, Kirsten; Silva, Mario; Bankier, Alexander A.

doi:10.1016/j.rcl.2013.09.002

Cited by 14 publications

(6 citation statements)

References 136 publications

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“…THORACIC IMAGING: Pulmonary Function and CT Attenuation in Chronic Obstructive Pulmonary Disease Paoletti et al C omputed tomography (CT) is currently considered the method of choice for providing accurate in vivo information about the pathologic changes in the lung that occur in chronic obstructive pulmonary disease (COPD) (1,2). Many CT studies have been dedicated to in vivo quantification of the extent and severity of Implications for Patient Care n Prediction of CT-determined emphysema with pulmonary function measurements might be of use in clinical practice and in clinical or pharmacologic studies in which CT is not feasible or cost-effective.…”

Section: Discussionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease: Pulmonary Function and CT Lung Attenuation Do Not Show Linear Correlation

Paoletti¹,

Cestelli²,

Bigazzi³

et al. 2015

Radiology

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Section: Discussionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease: Pulmonary Function and CT Lung Attenuation Do Not Show Linear Correlation

Paoletti¹,

Cestelli²,

Bigazzi³

et al. 2015

Radiology

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“…73,74 The characterization of parenchyma and airway in obstructive pulmonary diseases has been anatomically and functionally covered by volumetric and multiphase CT acquisition. 75,76 State of the art Parenchymal quantification Pulmonary texture in obstructive lung disease shows relatively low tightness compared to normal lung because of air abundance. Air abundance can be caused either by tissue loss (e.g.…”

Section: Obstructive Pulmonary Diseasementioning

confidence: 99%

Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications

Silva

Milanese

Seletti

et al. 2018

The British Journal of Radiology

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The frenetic development of imaging technology-both hardware and software-provides exceptional potential for investigation of the lung. In the last two decades, CT was exploited for detailed characterization of pulmonary structures and description of respiratory disease. The introduction of volumetric acquisition allowed increasingly sophisticated analysis of CT data by means of computerized algorithm, namely quantitative CT (QCT). Hundreds of thousands of CTs have been analysed for characterization of focal and diffuse disease of the lung. Several QCT metrics were developed and tested against clinical, functional and prognostic descriptors. Computer-aided detection of nodules, textural analysis of focal lesions, densitometric analysis and airway segmentation in obstructive pulmonary disease and textural analysis in interstitial lung disease are the major chapters of this discipline. The validation of QCT metrics for specific clinical and investigational needs prompted the translation of such metrics from research field to patient care. The present review summarizes the state of the art of QCT in both focal and diffuse lung disease, including a dedicated discussion about application of QCT metrics as parameters for clinical care and outcomes in clinical trials.

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“…upper lung, lower lung, diffuse), small airway disease, air‐trapping, bronchial wall dilatation, wall thickening, as well as large airway disease . With the introduction of clinical CT in the 1970s, and with the use of computer‐based image‐analysis methods (summary of technical terms and concepts is provided in Table ), the qualitative evaluation of underlying lung disease in COPD patients has matured to the evaluation of quantitative and objective regional measurements …”

Section: X‐ray Ctmentioning

confidence: 99%

This is what COPD looks like

2015

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Despite decades of research, and the growing healthcare and societal burden of chronic obstructive pulmonary disease (COPD), therapeutic COPD breakthroughs have not occurred. Sub-optimal COPD patient phenotyping, an incomplete understanding of COPD pathogenesis and a scarcity of sensitive tools that provide patient-relevant intermediate endpoints likely all play a role in the lack of new, efficacious COPD interventions. In other words, COPD patients are still diagnosed based on the presence of persistent airflow limitation measured using spirometry. Spirometry measurements reflect the global sum of all the different possible COPD pathologies and perhaps because of this, we lose sight of the different contributions of airway and parenchymal abnormalities. With recent advances in thoracic X-ray computed tomography (CT) and magnetic resonance imaging (MRI), lung structure and function abnormalities may be regionally identified and measured.These imaging endpoints may serve as biomarkers of COPD that can be used to better phenotype patients. Therefore, here we review novel CT and MRI measurements that help reveal COPD phenotypes and what COPD really 'looks' like, beyond spirometric indices. We discuss MR and CT imaging approaches for generating reproducible and sensitive measurements of COPD phenotypes related to pulmonary ventilation and perfusion as well as airway and parenchyma anatomical and morphological features. These measurements may provide a way to advance the development and testing of new COPD interventions and therapies.

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Multidetector Computed Tomographic Imaging in Chronic Obstructive Pulmonary Disease

Cited by 14 publications

References 136 publications

Chronic Obstructive Pulmonary Disease: Pulmonary Function and CT Lung Attenuation Do Not Show Linear Correlation

Chronic Obstructive Pulmonary Disease: Pulmonary Function and CT Lung Attenuation Do Not Show Linear Correlation

Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications

This is what COPD looks like

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