Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men

Mueller, S.; Gehrig, Saskia Maria; Frese, Sebastian; Wagner, Carsten A.; Boutellier, Urs; Toigo, Marco

doi:10.1186/1550-2783-10-16

Cited by 32 publications

(35 citation statements)

References 42 publications

(63 reference statements)

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“…Thus, a pCO2 value exceeding 45 mmHg is associated with respiratory inefficiencies and pH decrease in acid values [22]. pCO2 value which falls below 35 mmHg is associated with hyperventilation, and an increase in pH, in alkalosis stage [23].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: SECONDARY ELEMENTS OF BLOOD pH VARIATION CAN INFLUENCE THE EFFORT EFFECTIVENESS BASED ON ADAPTIVE CHANGES WITHIN A GROUP OF ELITE ATHLETES

Şa

Tomescu²,

Voidăzan

2016

Medicine and Pharmacy Reports

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AimpH is the direct indicator of the body reaction following the activities performed. Establishing precise correlations between pH and blood biochemical parameters might support the balancing of values during periods of marked physical activity.MethodWe conducted a case study in a group of elite rowers. Twelve athletes were included in the study. Monitoring was carried out by collecting biological samples several times a day: in the morning, 80 minutes pre-workout, 12 hours after the last physical effort performed, at two different times, 10 days apart. Determinations were aimed at adapting the reported biochemical parameters depending on the effort performed. The following parameters were monitored: pH, HCO3, pCO2, pO2, BE, SBE, SBC, Ca++, Mg++, LDH, GPT, T-Pro, and Alb.ResultsThe mean value of pH found in athletes was 7.41±0.024. The value obtained was significantly correlated to biochemical parameters such as BE (2.32±1.79), SBC (1.67±1.45), SBE (2.70±1.75). However, bicarbonate (HCO3) was statistically significantly related with SBE, SBC, SBE, and pO2, but did not present a strong association with the pH value (p=0.094). However, values such as Alb, Ca++, LDH, BE, SBC are related to pH value as a result of variations in the data submitted.ConclusionsThe processed data evidence the fact that blood pH, in this case, is significantly influenced by a number of indices that correlate energy system activity, individual adaptation to effort, and the recovery process. The parameters under investigation (SBE, SBC, SBE, CPK, LDH) are associated with pH changes that could confirm the recovery efficiency of the athlete, along with a possible metabolic acidosis/alkalosis.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: SECONDARY ELEMENTS OF BLOOD pH VARIATION CAN INFLUENCE THE EFFORT EFFECTIVENESS BASED ON ADAPTIVE CHANGES WITHIN A GROUP OF ELITE ATHLETES

Şa

Tomescu²,

Voidăzan

2016

Medicine and Pharmacy Reports

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“…Irrespective of performance, little is known about the acute and chronic consequences of regular GI disturbances, which may be detrimental to health. Previous investigations have examined the efficacy of various ingestion strategies such as multiday dosing (Mueller et al, 2013), split-dosing (Sale et al, 2011) and carbohydrate co-ingestion (Carr et al, 2011a) to reduce GI disturbances. However, regardless of adopting these strategies, GI disturbances remain problematic in some individuals following ingestion, therefore emphasising the need for alternative ingestion strategies (Lancha Junior et al, 2015 The primary aim of the present study was to determine the optimal ingestion form to minimise GI disturbances following NaHCO 3 ingestion.…”

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confidence: 99%

Enteric-Coated Sodium Bicarbonate Attenuates Gastrointestinal Side-Effects

Hilton

Leach

Craig

et al. 2020

International Journal of Sport Nutrition and Exercise Metabolism

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Enteric-formulated capsules can mitigate gastrointestinal (GI) side effects following sodium bicarbonate (NaHCO3) ingestion; however, it remains unclear how encapsulation alters postingestion symptoms and acid–base balance. The current study aimed to identify the optimal ingestion form to mitigate GI distress following NaHCO3 ingestion. Trained males (n = 14) ingested 300 mg/kg body mass of NaHCO3 in gelatin (GEL), delayed-release (DEL), and enteric-coated (ENT) capsules or a placebo in a randomized cross-over design. Blood bicarbonate anion concentration, potential hydrogen, and GI symptoms were measured pre- and postingestion for 3 hr. Fewer GI symptoms were reported with ENT NaHCO3 than with GEL (p = .012), but not with DEL (p = .106) in the postingestion phase. Symptom severity decreased with DEL (4.6 ± 2.8 arbitrary units) compared with GEL (7.0 ± 2.6 arbitrary units; p = .001) and was lower with ENT (2.8 ± 1.9 arbitrary units) compared with both GEL (p < .0005) and DEL (p = .044) NaHCO3. Blood bicarbonate anion concentration increased in all NaHCO3 conditions compared with the placebo (p < .0005), although this was lower with ENT than with GEL (p = .001) and DEL (p < .0005) NaHCO3. Changes in blood potential hydrogen were reduced with ENT compared with GEL (p = .047) and DEL (p = .047) NaHCO3, with no other differences between the conditions. Ingestion of ENT NaHCO3 attenuates GI disturbances for up to 3 hr postingestion. Therefore, ENT ingestion forms may be favorable for those who report GI disturbances with NaHCO3 supplementation or for those who have previously been deterred from its use altogether.

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“…Interestingly, there is some variety in the timing of pre-exercise administration in the literature which typically ranges from 60-90 min 29,30,31,32 . In some cases a multiple acute dose has been used starting at 90 mins and continuing until 50 min pre-exercise 33 or more chronic supplementation across several days 34 . This range of pre-exercise ingestion times are likely to influence the effectiveness of the supplement and therefore the magnitude of the potential performance benefits which are reported.…”

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confidence: 99%

Sodium bicarbonate ingestion and individual variability in time-to-peak pH

Sparks

Williams

Robinson

et al. 2016

Research in Sports Medicine

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The aim of this study was to determine the individual variability in time to peak pH after the consumption of a 300mg . kg -1 dose of sodium bicarbonate (NaHCO 3 ). Seventeen active males volunteered to participate in the study (mean ± SD: age 21.38 ± 1.5y; mass 75.8 ± 5.8kg; height 176.8 ± 7.6cm). Participants reported to the laboratory where a resting capillary blood sample was taken aseptically from the fingertip. After this, 300 mg . kg -1 of NaHCO 3 in 400ml of water with 50ml of flavoured cordial was ingested.Participants then rested for 90 min during which repeated blood samples were procured at 10 minute intervals for 60 mins and then every 5 min until 90 min. Blood pH concentrations were measured using a blood gas analyser. Results suggested that time to peak pH (64.41±18.78 min) was highly variable with a range of 10-85 min and a coefficient of variation of 29.16%. A bi-modal distribution occurred, at 65 and 75 min. In conclusion, researchers and athletes, when using NaHCO 3 as an ergogenic aid, should determine, in advance their time to peak pH to best utilise the added buffering capacity this substance allows.

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Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men

Cited by 32 publications

References 42 publications

RETRACTED: SECONDARY ELEMENTS OF BLOOD pH VARIATION CAN INFLUENCE THE EFFORT EFFECTIVENESS BASED ON ADAPTIVE CHANGES WITHIN A GROUP OF ELITE ATHLETES

RETRACTED: SECONDARY ELEMENTS OF BLOOD pH VARIATION CAN INFLUENCE THE EFFORT EFFECTIVENESS BASED ON ADAPTIVE CHANGES WITHIN A GROUP OF ELITE ATHLETES

Enteric-Coated Sodium Bicarbonate Attenuates Gastrointestinal Side-Effects

Sodium bicarbonate ingestion and individual variability in time-to-peak pH

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