Multicystic degeneration of the Cowper's gland in a Large White boar

Grahofer, Alexander; Gurtner, Corinne

doi:10.1111/rda.12768

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Due to the high use of semen from boar studs for artificial insemination, there is an increased risk of distributing a hereditary disease in the pig population [33][34][35]. Therefore, a thorough diagnostic and rapid analysis of this genetic disorder was conducted to avoid spreading of the disease in the pig population.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and Genomic Analysis of Cystic Hygroma in Pigs

Letko

Schauer

Derks

et al. 2021

Genes

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Cystic hygroma is a malformation of the lymphatic and vascular system and is recognized as a benign congenital tumor that affects humans and animals in the perinatal period. This congeni-tal disorder is rarely described in animals, and until today, cystic hygroma in pigs has not been described in the literature. In a purebred Piètrain litter with twelve live-born piglets, cystic hy-groma was noticed on the rump of two male pigs within the first week of life. In addition, a third case of a crossbred weaner (Large White × Landrace) was detected during a herd examina-tion. To rule out common differential diagnoses, e.g., abscess or hematoma, further clinical and pathological investigations were conducted. During clinical examination, a painless and soft mass, which was compressible, was detected on the rump of all affected animals. The ultra-sonographic examination revealed a fluid-filled and cavernous subcutaneous structure. In addi-tion, a puncture of the cyst was conducted, revealing a serosanguinous fluid with negative bacte-riological culture. In all cases, a necropsy was performed, showing that the animals had fluid-filled cysts lined by well-differentiated lymphatic endothelium. Based on the clinicopathological examination, cystic hygroma was diagnosed. Furthermore, SNP array genotyping and whole-genome sequencing was performed and provided no evidence for a chromosomal disorder. In the Piètrain family, several genome regions were homozygous in both affected piglets. None-theless, a dominant acting de novo germline variant could not be ruled out, and therefore differ-ent filtering strategies were used to find pathogenic variants. The herein presented lists of pri-vate variants after filtering against hundreds of control genomes provide no plausible candidate and no shared variants among the two sequenced cases. Therefore, further studies are needed to evaluate possible genetic etiology. In general, systematic surveillance is needed to identify ge-netic defects as early as possible and to avoid the occurrence of losses in the pig population.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and Genomic Analysis of Cystic Hygroma in Pigs

Letko

Schauer

Derks

et al. 2021

Genes

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“…The relative hyperintensity of the prostate part, compared to the hypointensity of the proprostate and paraprostate parts, has demonstrated the important role of the prostate part in the secretory function of the glandular complex [12]. An MRI anatomical study of the urethra and periurethral tissues has been used in the morphological investigation of urethral anomalies in humans, such as Syringocele, Cobb's collar, cowperitis, lithiasis and cancer [13][14][15][16][17][18][19][20]. In an MRI (T2-weighted images) of the urogenital diaphragm in the man, the bulbourethral glands appeared as encapsulated, heterogeneous findings with intermediate intensity.…”

Section: Introductionmentioning

confidence: 99%

MRI Anatomical Investigation of Rabbit Bulbourethral Glands

Dimitrov

Stamatova-Yovcheva

2023

Animals

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Anatomical MRI is appropriate for the interpretation of soft tissue findings in the retroperitoneal part of the pelvic cavity. The aim of the current study was to use rabbits as an imaging model to optimize MRI protocols for the investigation of bulbourethral glands. The research was conducted on twelve clinically healthy, sexually mature male rabbits, eight months of age (New Zealand White), weighing 2.8 kg to 3.2 kg. Tunnel MRI equipment was used. The transverse MRI in the T2-weighted sequence obtained detailed images that were of higher anatomical contrast than those in T1-weighted sequences. The hyperintensity of the glandular findings at T2, compared to the adjacent soft tissues, was due to the content of secretory fluids. The quality of the anatomical tissue contrast has not shown much dependence on the choice of the sequence in dorsal MRI. The sagittal visualization of the rabbit bulbourethral glands corresponded to the localization of the research plane toward a median plane. The imaging results could be used as a morphological base for clinical practice and reproduction.

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