Multicore Magnetic Nanoparticles Coated with Oligomeric Micelles: Characterization and Potential for the Extraction of Contaminants over a Wide Polarity Range

Abstract

Oligomeric micelles from sodium undecylenate (oSUD) were chemisorbed to magnetic iron oxide nanoparticles (MNPs) through a single-step synthetic route involving the simultaneous nanoparticle formation and functionalization in an aqueous medium. The resulting spherical nanoparticles (MNPs-oSUD) consisted of a concatenation of iron oxide cores, with an average size of 7.7 nm, bound by oSUD micelles (particle average diameter of ca. 200 nm). Micellar coverage was ∼50% of the MNP-oSUD (by weight) and offered multiple retention mechanisms (e.g., dispersion, hydrogen bonding, polar, and ionic) for solute solubilization while keeping it intact during analyte elution. The high density of micelles and variety of interactions provided by this sorbent rendered it highly efficient for the extraction of aromatic amines in a wide polarity range (log K values from -0.80 to 4.05) from textiles, urine, and wastewater. Extraction took 5 min, no cleanup or evaporation of the extracts was needed and the method, based on LC-MS/MS quantitation, proved matrix-independent. Recoveries for 17 aromatic amines in samples were in the range of 93%-123% while those with negative log K values were in the range of 69%-87%. Detection limits for aromatic amines in textiles (0.007-2 mg kg) were well below the limits legislated by the European Union (EU) (30 mg kg) and those in urine and wastewater (0.004-1.5 μg L) were at the level usually found in real-world applications. All the analyzed samples were positive in aromatic amines. The easy synthesis and excellent extraction properties of MNPs-oSUD anticipate their high potential not only for multiresidue analysis but also in other fields such as water remediation.

Novel Magnetic Microprobe with Benzoboroxole-Modified Flexible Multisite Arm for High-Efficiency cis-Diol Biomolecule Detection

“…Magnetic nanoparticles are widely used in target extraction and enrichment, because of their outstanding convenience for retrieval from a sample matrix. − In addition, the modifiable surface and high specific surface area make it the superior platform for a variety of diverse applications in the field of analytical chemistry. − We also noticed the recent reported boronic acid derivatives; ortho -hydroxymethyl-phenylboronic acids (benzoboroxoles) showed excellent water solubility and improved cis -diol units binding capacity, even superior to the Wulff-type boronic acid in neutral water. − Inspired by these, we anticipated that the combination of the advantages of magnetic extraction and benzoboroxoles receptor enable the development of a high-efficiency approach for saccharides or glycoproteins detection.…”

Highly Chemiluminescent Magnetic Beads for Label-Free Sensing of 2,4,6-Trinitrotoluene

“…Over the past decade, magnetic materials have attracted considerable attention due to their excellent performance in the fields of bioassays, − drug delivery, − electronics, , magnetic resonance imaging, − and environmental remediation. − As typical magnetic materials, magnetic beads (MBs) can be concentrated, trapped, or used in rapid separation by applying a magnetic field. Owing to their outstanding properties, such as high loading capacity, high magnetic susceptibility, and good biocompatibility, MBs have extensively been used for label-based bioassays such as immunoassays − and DNA assays. − Particularly, label-based chemiluminescence (CL) technology with MBs has been successfully commercialized in immunoassays.…”

Multi-Functional Drug Carrier Micelles With Anti-inflammatory Drug

“…The micelles synthesized in this study showed the good outcomes form the LCST results and anti-inflammation drug releasing tests in a narrow window of pH change of 6.6 and 7.4, which compared other micelles pH-dependent LCST responding to different pH value of 5.5 and 7.4 (Yu et al, 2014) and pH value of 5 and 7.4 (Chen et al, 2013). In addition, magnetic nanoparticle grafted on PNDU micelles provided a higher magnetic property which was 6.67 emu/g, than others MNPs-loaded micelles 0.06 emu/g (Yang et al, 2016), 1.71 emu/g (Naous et al, 2017) it promoted the potential of magnetic targeting or other manipulating application.…”