Multicore Magnetic Fe<sub>3</sub>O<sub>4</sub>@C Beads With Enhanced Magnetic Response for MRI in Brain Biomedical Applications

Vargas-Osorio, Zulema; Argibay, Bárbara; Piñeiro, Yolanda; Vázquez–Vázquez, C.; López‐Quintela, M. Arturo; Alvarez-Perez, M. A.; Sobrino, Tomás; Campos, Francisco; Castillo, José; Rivas, José

doi:10.1109/tmag.2016.2529699

Cited by 16 publications

(12 citation statements)

References 13 publications

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“…In spite of the certainly wide variety of magnetic nanoparticles (MNPs) with different geometries, compositions and functionalizations [1,2,3,4,5,6,7,8] that have become available in recent years, and of the number of applications that have been devised for them [1,9,10,11,12], when the goal is to provide a nanocarrier suitable for targeted chemotherapy, there is still room for progress. On one hand, the methods for obtaining MNPs need to be more cost- and time-effective, eco-friendly, and scalable.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

et al. 2019

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In this work we report on the synthesis and characterization of magnetic nanoparticles of two distinct origins, one inorganic (MNPs) and the other biomimetic (BMNPs), the latter based on a process of bacterial synthesis. Each of these two kinds of particles has its own advantages when used separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality (around pH 4.4), while MNPs show a zero-zeta potential at pH 7, and appear to be excellent agents for magnetic hyperthermia. This means that the biomimetic particles are better suited to be loaded with drug molecules positively charged at neutral pH (notably, doxorubicin, for instance) and releasing it at the acidic tumor environment. In turn, MNPs may provide their transport capabilities under a magnetic field. In this study it is proposed to use a mixture of both kinds of particles at two different concentrations, trying to get the best from each of them. We study which mixture performs better from different points of view, like stability and magnetic hyperthermia response, while keeping suitable drug transport capabilities. This composite system is proposed as a close to ideal drug vehicle with added enhanced hyperthermia response.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

et al. 2019

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“…[ 84 ] Vargas-Osorio et al . [ 85 ] have assessed magnetite-carbon nanoparticles with core-shell structure, which have been synthesized through SFM, for both hyperthermia and MRI in brain biomedical applications. Despite mentioned applications, the biocompatibility of as-prepared nanoparticles has been assessed and the results showed that their biological performance shows very good biocompatibility and labeling capacities after incubation in rat mesenchymal stem cells.…”

Section: Case Study Of Spinel Ferrite Nanoparticlesmentioning

confidence: 99%

Solvothermal synthesis of magnetic spinel ferrites

2018

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At present, solvothermal fabrication method has widely been applied in the synthesis of spinel ferrite nanoparticles (SFNs), which is mainly because of its great advantages such as precise control over size, shape distribution, and high crystallinity that do not require postannealing treatment. Among various SFNs, Fe3O4 nanoparticles have attracted tremendous attention because of their favorable physical and structural properties which are advantageous, especially in biomedical applications, among which the vast application of these materials as targeted drug delivery systems, hyperthermia, and imaging agents in cancer therapy can be mentioned. The main focus of this study is to present an introduction to solvothermal method and key synthesis parameters of SFNs through this synthesis route. Moreover, most recent progress on the potential applications of Fe3O4 nanoparticles as the most important compound among the spinel ferrites family members is discussed.

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“…To date, several Pd-doped MNPs were successfully synthesized and used as the catalyst for C-C bond formation reactions. [34,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] The C-C bond formation reaction is a critical synthesis procedure in synthesizing natural products, agrochemicals, biologically active compounds, and pharmaceuticals. [33,34,38,44,48,50,[54][55][56] Although structurally similar catalysts exist in the literature, Pd complex of NHC ligand attached to the supporting material via the OH-group is not available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Magnetite@MCM‐41 nanoparticles as support material for Pd‐N‐heterocyclic carbene complex: A magnetically separable catalyst for Suzuki–Miyaura reaction

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et al. 2021

Applied Organom Chemis

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The Magnetite@MCM‐41@NHC@Pd catalyst was obtained with Pd metal bound to the NHC ligand anchored to the surface of Fe3O4@MCM‐41. It was characterized by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), energy disperse X‐ray analysis (EDX), thermogravimetric analysis (TGA), differential thermal analysis (DTA), and scanning electron microscopy (SEM). The amount of Pd in the Magnetite@MCM‐41@NHC@Pd was measure by inductively coupled plasma–optical emission spectroscopy (ICP‐OES) analysis. The catalytic activity of Magnetite@MCM‐41@NHC@Pd heterogeneous catalyst done on Suzuki–Miyaura reactions of aryl halides with different substituted arylboronic acid derivatives. All coupling reactions afforded excellent yields and up to 408404 Turnover Frequency (TOF) h−1 in the presence of 2 mg of Magnetite@MCM‐41@NHC@Pd catalyst (0.0564 mmol g−1, 0.01127 mmol% Pd) at room temperature in 2‐propanol/H2O (1:2). Moreover, Magnetite@MCM‐41@NHC@Pd catalyst was recover by applying the magnet and reused for another reaction. The catalyst showed excellent structural and chemical stability and reused ten times without a substantial loss in its catalytic performance.

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Multicore Magnetic Fe₃O₄@C Beads With Enhanced Magnetic Response for MRI in Brain Biomedical Applications

Cited by 16 publications

References 13 publications

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Solvothermal synthesis of magnetic spinel ferrites

Magnetite@MCM‐41 nanoparticles as support material for Pd‐N‐heterocyclic carbene complex: A magnetically separable catalyst for Suzuki–Miyaura reaction

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Multicore Magnetic Fe3O4@C Beads With Enhanced Magnetic Response for MRI in Brain Biomedical Applications

Cited by 16 publications

References 13 publications

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Solvothermal synthesis of magnetic spinel ferrites

Magnetite@MCM‐41 nanoparticles as support material for Pd‐N‐heterocyclic carbene complex: A magnetically separable catalyst for Suzuki–Miyaura reaction

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Product

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Multicore Magnetic Fe₃O₄@C Beads With Enhanced Magnetic Response for MRI in Brain Biomedical Applications