Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity

Abstract

The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH 3 ) 2 ) 2 O] 4 {[CeW 5 O 18 ] [TeW 4 O 16 ]-[CeSn(CH 3 ) 2 ] 4 [TeW 8 O 31 ] 4 } 2 } 46À (1 a) features dimensions of ca. 2.2 2.3 3.4 nm 3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.

Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity

“…Furthermore, several previous studies reported that the oral administration of POMs is presumed safe with a low risk of negative health effects. ,− For instance, polyoxotungstates show a potential antitumor activity and lower toxicity in vitro as well as in vivo experiments . Especially, vanadotungstates and polyoxovanadates have evidenced a good antitumor activity against some human cancer cells (MCF-7 human breast cells, HepG2 hepatocellular carcinoma cell, etc.)…”

Synthesis of a Polyoxometalate-Encapsulated Metal–Organic Framework via In Situ Ligand Transformation Showing Highly Catalytic Activity in Both Hydrogen Evolution and Dye Degradation

“…The unique properties of POMs with various sizes, shapes, and high negative charges could enable the POM-based MOFs to exhibit adjustable porous sizes. , In addition, besides their structural advantages, POMs allow chemical and structural modifications at a molecular level and can carry out reversible, fast, and multistep electron-transfer reactions without changing their structures. , Therefore, POM-encapsulated MOFs have emerged as a new family of multifunctional hybrids that includes two key research fields: MOFs and POMs. One of the first proposed applications of POM-encapsulated MOFs is in heterogeneous catalysis, and thus, recently, such materials have made significant contributions to fields such as photo- and electrocatalysis. − Nevertheless, very few examples of POM-encapsulated MOFs have been reported because the assembly of such MOFs is still a significant synthetic challenge. − Organic ligands are key synthons to obtain the desired MOF skeleton . Mixed-ligand MOFs have more advantages than single-ligand ones, as a high level of practical molecular design and the potential synergetic coordinated interactions of distinct ligands with metals result in novel POM-encapsulated MOFs .…”

Engineering Nonprecious Metal Oxides Electrocatalysts for Two‐Electron Water Oxidation to H2O2

“…Considering the crucial role of multiple intermediates adsorption over the electrocatalyst's surface/interfaces, more attention should be paid to creating multi-active sites in one catalytic material like high-entropy alloys to collaboratively optimize their interaction with different intermediates during 2e-WOR. [128][129][130][131][132][133][134] Recent years have witnessed a surge of interest in restructuring and strain engineering of nanocatalysts for electrocatalytic applications with improved activities including hydrogen evolution, oxygen reduction, and oxygen evolution, which may be extendable for 2e-WOR catalysts. [135,136] To promote mass transfer, tailoring the morphology of the catalysts with 3D hierarchically open porous architectures can effectively increase the availability of active sites and accelerate the diffusion of relevant species.…”