Multicomponent reactions in nucleoside chemistry

Abstract

SummaryThis review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized types of the MCRs. Biochemical properties of the novel nucleoside analogs are also presented (if provided by the authors).

Nucleoside Analogues as Antibacterial Agents

“…One class of drugs that are important from a clinical perspective is nucleoside analogues, a pharmacologically diverse class of drugs that arose from chemically modified natural ribose or 2′-deoxyribose nucleosides (Koszytkowska-Stawinska and Buchowicz, 2014). Nucleoside analogues are among the most important drugs in the clinical setting and are used widely as both anticancer and antiviral agents (Jordheim et al., 2013).…”

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

“…They all increase the application options for MCRs, such as MCR nanosystems and mechanochemical reactions [65]. MCRs have been also applied in polymer [74], nucleoside [75] and carbohydrate [76] chemistry. Main field of application remains the production of heterocyclic compounds and many natural products by means of MCR [38,[77][78][79][80][81][82][83][84][85][86][87][88][89], leading directly towards drug design and discovery [90][91][92][93][94].…”

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

“…They all increase the application options for MCRs, such as MCR nanosystems and mechanochemical reactions [ 65 ]. MCRs have been also applied in polymer [ 74 ], nucleoside [ 75 ] and carbohydrate [ 76 ] chemistry. Main field of application remains the production of heterocyclic compounds and many natural products by means of MCR [ 38 , 42 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ], leading directly towards drug design and discovery [ 89 , 90 , 91 , 92 , 93 ].…”