Multicomponent Reactions-Based Modified/Functionalized Materials in the Biomedical Platforms

Javanbakht, Siamak; Shaabani, Ahmad

doi:10.1021/acsabm.9b00799

Cited by 55 publications

(26 citation statements)

References 132 publications

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“…The structural resemblance of these compounds to the coenzyme reduced nicotinamide adenine dinucleotide (NADH) sparked the potential pharmaceutical properties, and till today, the Hantzsch synthesis is the main route for obtaining such products, which are eventually used as active pharmaceutical ingredients in the pharmaceutical industry [ 3 , 8 ]. An analysis of the market shows that there are over 7000 drugs derived from dihydropyridines, some of which are blockbuster drugs, such as Tamiflu ® , dioscorine, ibogaine, and isoquinuclidines [ 9 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

Bosica¹,

Demanuele²,

Padrón³

et al. 2020

Beilstein J. Org. Chem.

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A rapid route for obtaining unsymmetrical 1,2-dihydropyridines (1,2-DHPs) as opposed to 1,4-dihydropyridines (1,4-DHPs) has been achieved via a one-pot multicomponent Hantzsch reaction. A benign protocol has been developed for the preparation of various 1,2-dihydropyridine derivatives using heterogenized phosphotungstic acid on alumina support (40 wt %). High yields of over 75% have been accomplished in just 2–3.5 h after screening several heterogeneous catalysts and investigating the optimal reaction conditions. The catalyst chosen has passed the heterogeneity test and was shown to have the potential of being reused for up to 8 consecutive cycles before having a significant loss in activity. In addition, aromatic aldehydes gave the aforementioned regioisomer while the classical 1,4-DHPs were obtained when carrying out the reaction using aliphatic aldehydes. The preliminary study of the antiproliferative activity against human solid tumor cells demonstrated that 1,2-DHPs could inhibit cancer cell growth in the low micromolar range.

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Section: Introductionmentioning

confidence: 99%

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

Bosica¹,

Demanuele²,

Padrón³

et al. 2020

Beilstein J. Org. Chem.

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“…Javanbakht et al synthesized a pH-responsive photoluminescent nanocarrier via encapsulation of graphene quantum dots by MIPs. [199] A pH-responsive MIP layer was fabricated via precipitation FRP in water media using doxorubicin, 2-hydroxyethyl methacrylate, and N,N′-methylenebisacrylamide ethylene as the template, functional monomer, and crosslinker, respectively, to form a nontoxic and biocompatible drug delivery system. In vitro drug release studies revealed that at a pH of 7.4, minimal drug leakage occurred, which could decrease harmful effects in normal tissues.…”

Section: Ph-responsive Mipsmentioning

confidence: 99%

Molecular Imprinting: Green Perspectives and Strategies

et al. 2021

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Large quantities of organic solvents and reagents are usually required in the fabrication of these materials. Moreover, the use of excess reagents in solvent extraction, purification, filtration/ centrifugation, and cleaning processes is essential for adequate product purity. Because of the numerous practical applications of advanced materials, some are synthesized on a large scale and commercialized. [3] The excessive consumption of nonrenewable, hazardous chemicals is an unsustainable practice and a prominent criticism of these materials. Nonetheless, the use of advanced materials in sensing applications, medicine, electronics, and catalysis is inevitable. [4] During various research activities, such as fabricating advanced materials, as well as in the subsequent stage, i.e., industrial operations, new challenges have arisen that impact not only almost every aspect of human life but also other living creatures and ecosystems. It is estimated that the impact of these practices will endure into the next century. [5] Since the advancement of science, industry, and technology is inevitable, scientists have been persuaded to search for methods to counteract or minimize the negative impacts of human activities. [6] Thus, green chemistry has advanced and green principles have been defined for most sciences, including synthesis, [7] analytical chemistry, [8] engineering, [9] and pharmaceutical science. [10] Fortunately, contemporary society has great awareness of deleterious environmental side effects, resulting in a sense Advances in revolutionary technologies pose new challenges for human life; in response to them, global responsibility is pushing modern technologies toward greener pathways. Molecular imprinting technology (MIT) is a multidisciplinary mimic technology simulating the specific binding principle of enzymes to substrates or antigens to antibodies; along with its rapid progress and wide applications, MIT faces the challenge of complying with green sustainable development requirements. With the identification of environmental risks associated with unsustainable MIT, a new aspect of MIT, termed green MIT, has emerged and developed. However, so far, no clear definition has been provided to appraise green MIT. Herein, the implementation process of green chemistry in MIT is demonstrated and a mnemonic device in the form of an acronym, GREENIFICATION, is proposed to present the green MIT principles. The entire greenificated imprinting process is surveyed, including element choice, polymerization implementation, energy input, imprinting strategies, waste treatment, and recovery, as well as the impacts of these processes on operator health and the environment. Moreover, assistance of upgraded instrumentation in deploying greener goals is considered. Finally, future perspectives are presented to provide a more complete picture of the greenificated MIT road map and to pave the way for further development.

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“…Isocyanides are hubs in chemistry, having reaction plasticity yet conserved reactivities, and can function as integral members of large multimolecular assemblies, or just contribute a few atoms. The isocyanide functional group is of high relevance to different fields of science, 1 including astronomy, 2 biology, 3 information technology, 4,5 materials science, 6 and most importantly chemistry. 7 Isocyanides are isolobal to carbon monoxide and therefore there is a rich metalorganic chemistry.…”

Section: Introductionmentioning

confidence: 99%

“…A recent bibliometric analysis using Sci-Finder revealed that isocyanides are mentioned in >21 000 publications, excluding patents. However, just 9 isocyanides (1)(2)(3)(4)(5)(6)(7)(8)(9) account for >19 000 citations (>90%) of all isocyanide research papers. These reoccurring isocyanides are the commercially available tert-butyl 1, cyclohexyl isocyanide 2, TOSMIC 3, isocyanoaceticacid esters 4 and 9, 2,6-dimethyl phenyl 5, benzyl 6, methyl 7 and phenyl isocyanide 8.…”

Section: Introductionmentioning

confidence: 99%