Multicomponent Reactions: A Brief History and their Versatility for the Synthesis of Biologically Active Molecules

Bio Inspired CdO Nanoparticles: A Robust and Recyclable Catalyst Towards the Synthesis of Dihydropyrimidone Derivatives via One Pot Three‐Component Coupling Reaction

“…One-pot multicomponent reactions (MCRs) have gained considerable prominence in recent times, involving the combination of three or more reactants to yield a product containing all constituent atoms. [1,2] Such reactions have garnered substantial importance within the realm of organic synthesis due to their atomic and energetic efficiency, making them highly advantageous compared to linear organic synthesis approaches in terms of their applications within the fields of organic chemistry and pharmacology. [3][4][5] Amongst these, the Biginelli reaction stands out as one of the most versatile multicomponent reactions (MCRs), [6][7][8][9][10] with its products finding significant relevance in diverse biological activities, including anticancer, [11] antimicrobial and therapeutic agents, [12,13] anti-inflammatory, antibacterial, and antifungal agents.…”

“…One‐pot multicomponent reactions (MCRs) have gained considerable prominence in recent times, involving the combination of three or more reactants to yield a product containing all constituent atoms [1,2] . Such reactions have garnered substantial importance within the realm of organic synthesis due to their atomic and energetic efficiency, making them highly advantageous compared to linear organic synthesis approaches in terms of their applications within the fields of organic chemistry and pharmacology [3–5] .…”