Multicomponent Polyanions. 43. A Study of Aqueous Equilibria in the Vanadocitrate System.

Probing for missing links in the binary and ternary V(V)–citrate–(H2O2) systems: Synthetic efforts and in vitro insulin mimetic activity studies

“…A number of solution studies have been carried out, in the past, on V(V) [29][30][31][32][33][34][35] and V(IV) [24] bioinorganic systems. Among these, the study on the binary V(V)-citrate system stands prominent, proposing the existence of dinuclear species in aqueous biodistribution schemes throughout the physiological pH range [35].…”

“…Concurrently, it has been shown to exhibit bioactivities including antitumorigenicity [14][15][16], mitogenicity [17,18], and inhibition of metabolic enzymes such as phosphoglucomutases and others [19,20]. Noteworthy, however, has been the association of vanadium with the heterogeneous syndrome of Diabetes mellitus by virtue of its insulin mimetic activity [21][22][23][24][25][26][27][28][29][30][31][32][33].…”

“…Understanding such interactions has been one of the most significant goals of vanadium research, specifically targeting the solubility and biovailability of vanadium species bound to organic substrates. To this end, solution speciation studies [24][25][26][27][28][29][30][31][32][33][34][35] projecting fundamental characteristics on binary and ternary vanadium systems, containing physiological as well as biologically relevant ligands, were reported. Among the various ligands studied in the presence of vanadium were hydroxycarboxylate-containing organic ligands, such as citric acid.…”

Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates

“…The interpretation of the 51 V NMR spectral data was supplemented by speciation calculations based on constants measured previously (Pettersson et al, 1983 ; Ehde et al, 1989 ; Selling et al, 1994 ). The species distribution diagrams were calculated by using HySS 2009 software (Alderighi et al, 1999 ; Carsella et al, 2017 ) and known speciation constants of the system at hand (Pettersson et al, 1983 ; Ehde et al, 1989 ; Selling et al, 1994 ). The citrate and the phosphate concentrations found in the Middlebrook 7H9 broth medium supplemented with 5% BSA, 2% dextrose, 5% catalase (ADC) enrichment, glycerol (0.2%, v/v), and Tween 80 (0.05%, v/v) were 0.48 and 24 mM, respectively ( Bbl tm , 2018 ).…”

“…The vanadium concentrations that were investigated were concentrations of 5, 3.3, and 10 mM. The speciation diagrams were constructed using the following equilibrium reactions for the binary H + -H 2 V system [see equation (1)] (Pettersson et al, 1983 ), and two ternary system, H + -H 2 V C 6 H 5 and H + -H 2 V H 2 P [see equation (2) (Ehde et al, 1989 ) and (3) (Selling et al, 1994 )]. The alternate formulas were provided in the format of the equations provided for comparison.…”