Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration

Zhong, Jinwei; Zhang, Qingfei; Kuang, Gaizhen; Xia, Junhui; Shang, Luoran

doi:10.1016/j.cej.2022.140585

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…This approach showed promise both in vitro and in vivo. Zhong et al conducted a study on multicomponent microspheres (MCMs) designed for post-surgical liver cancer treatment and regeneration (Figure 6J,K) [299]. Utilizing a microfluidic platform, they created MCMs with a sodium alginate (Alg) shell and gelatin methacrylate (GelMA) cores, enabling the dual-drug delivery of doxorubicin and liver regeneration augmenter.…”

Section: Biomedical Applications Of Hybrid Hydrogelsmentioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matrix. Recent chemical advancements have bolstered their versatility, facilitating the integration of the molecules guiding cellular activities and enabling their controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which adversely affect their mechanical properties, diffusion rates, and biological activity. In response to these challenges, hybrid hydrogels have emerged, aiming to enhance their strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. The scientific community has increasingly recognized the versatile characteristics of hybrid hydrogels, particularly in the biomedical sector. This comprehensive review delves into recent advancements in hybrid hydrogel systems, covering the diverse types, modification strategies, and the integration of nano/microstructures. The discussion includes innovative fabrication techniques such as click reactions, 3D printing, and photopatterning alongside the elucidation of the release mechanisms of bioactive molecules. By addressing challenges, the review underscores diverse biomedical applications and envisages a promising future for hybrid hydrogels across various domains in the biomedical field.

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Section: Biomedical Applications Of Hybrid Hydrogelsmentioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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“…In addition, these MCMs exhibited a rapid release of DOX and a persistent release of ALR. These dual-drug-loaded MCMs exhibited significant postoperative tumor-killing effects and the promotion of liver regeneration [105]. Espinoza et al studied the efficiency of a dual-pH-sensitive intelligent nanocarrier based on silica nanoparticles (SNPs) extracted from rice husk ash (RHAs) in the inhibition of liver cancer cell proliferation.…”

Section: Research Progress On Dual-drug-delivery Nano-theranostic Age...mentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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Liver cancer has high incidence and mortality rates and its treatment generally requires the use of a combination treatment strategy. Therefore, the early detection and diagnosis of liver cancer is crucial to achieving the best treatment effect. In addition, it is imperative to explore multimodal combination therapy for liver cancer treatment and the synergistic effect of two liver cancer treatment drugs while preventing drug resistance and drug side effects to maximize the achievable therapeutic effect. Gold nanoparticles are used widely in applications related to optical imaging, CT imaging, MRI imaging, biomarkers, targeted drug therapy, etc., and serve as an advanced platform for integrated application in the nano-diagnosis and treatment of diseases. Dual-drug-delivery nano-diagnostic and therapeutic agents have drawn great interest in current times. Therefore, the present report aims to review the effectiveness of dual-drug-delivery nano-diagnostic and therapeutic agents in the field of anti-tumor therapy from the particular perspective of liver cancer diagnosis and treatment.

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Netrin1-carrying magnetic microspheres with magnetic field activate neurotrophin factors to guide neuronal outgrowth in vitro and in vivo

Liu,

An,

et al. 2024

Chemical Engineering Journal

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Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration

Cited by 10 publications

References 33 publications

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Netrin1-carrying magnetic microspheres with magnetic field activate neurotrophin factors to guide neuronal outgrowth in vitro and in vivo

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