Multicomponent metal-organic framework nanocomposites for tumor-responsive synergistic therapy

Hur, Won; Park, Yeongwon; Seo, EunBi; Son, Seong Eun; Kim, Seongnyeon; Seo, Hyemyung; Seong, Gi Hun

doi:10.1016/j.jcis.2023.04.161

Cited by 7 publications

(1 citation statement)

References 55 publications

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“…Due to their different iron oxidation states, Prussian blue nanoparticles (PBNPs) exhibit multifunctional catalytic activities, including peroxidase (POD), catalase (CAT), and superoxide dismutase-like activities (Estelrich and Busquets 2021). Currently, PBNPs have garnered significant attention in cancer treatment, with widespread applications in diseases such as lung cancer, breast cancer, and melanoma (Hur et al 2023;Sahoo et al 2023;Wang, Chiou, et al 2023). However, their application research in OSCC treatment is limited.…”

Section: Introductionmentioning

confidence: 99%

An Acid-Responsive Iron-Based Nanocomposite for OSCC Treatment

Zhao,

Leng,

Wang

et al. 2024

J Dent Res

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Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, characterized by invasiveness, local lymph node metastasis, and poor prognosis. Traditional treatment and medications have limitations, making the specific inhibition of OSCC growth, invasion, and metastasis a challenge. The tumor microenvironment exhibits mildly acidity and high concentrations of H2O2, and its exploitation for cancer treatment has been widely researched across various cancers, but research in the oral cancer field is relatively limited. In this study, by loading ultra-small Prussian blue nanoparticles (USPBNPs) into mesoporous calcium–silicate nanoparticles (MCSNs), we developed an acid-responsive iron-based nanocomposite, USPBNPs@MCSNs (UPM), for the OSCC treatment. UPM demonstrated excellent dual enzyme activities, generating toxic ·OH in a mildly acidic environment, effectively killing OSCC cells and producing O2 in a neutral environment to alleviate tissue hypoxia. The results showed that UPM could effectively inhibit the proliferation, migration, and invasion of OSCC cells, as well as the growth of mice solid tumors, without obvious systemic toxicity. The mechanisms may involve UPM inducing ferroptosis of OSCC cells by downregulating the xCT/GPX4/glutathione (GSH) axis, characterized by intracellular iron accumulation, reactive oxygen species accumulation, GSH depletion, lipid peroxidation, and abnormal changes in mitochondrial morphology. Therefore, this study provides empirical support for ferroptosis as an emerging therapeutic target for OSCC and offers a valuable insight for future OSCC treatment.

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Section: Introductionmentioning

confidence: 99%

An Acid-Responsive Iron-Based Nanocomposite for OSCC Treatment

Zhao,

Leng,

Wang

et al. 2024

J Dent Res

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Advanced porous materials for antimicrobial treatment

Miguel Sábio,

Corrêa Carvalho,

et al. 2023

Nano Select

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Infectious diseases are a global public health concern generated by uncontrolled uses of antimicrobials resulting in multidrug‐resistant (MDR) pathogens. The antimicrobial resistance (AMR) has made explicit the ineffective action of the current medicines and vaccines. Rapid diagnosis and effective treatment are the keys to reduce the capacity of MDR pathogens spreading very fast, avoiding high socioeconomic impact, severe and prolonged illness and death. Advanced porous materials have emerged as promising alternatives to the conventional diagnoses and therapy due to their low‐cost production, high biocompatibility, adjustable porous structure, large surface area, easy surface functionalization and capacity of loading high drugs amount. In this review, we first highlighted the current strategies to fight against infectious diseases. Then, we introduce the main advanced porous materials used in infectious diseases, including mesoporous silica nanoparticles (MSNs), porous silicon nanoparticles (PSiNPs), metal–organic frameworks (MOFs), covalent–organic frameworks (COFs), hydrogen‐bonded organic frameworks (HOFs) and porous carbon materials. The strategies to fabricate these materials and their characterization for the application in the recent years for antimicrobial treatment is also discussed. Finally, we present an overview outlook and challenges on the future application of such materials for infectious diseases.

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