Multicomponent Fibers by Multi‐interfacial Polyelectrolyte Complexation

Wan, Andrew C.A.; Leong, Meng Fatt; Toh, Jerry K. C.; Zheng, Yuangang; Ying, Jackie Y.

doi:10.1002/adhm.201100020

Cited by 55 publications

(44 citation statements)

References 21 publications

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“…Micro/nanoscaled fibres have recently gained attention for tissue engineering approaches due to their promising potential for constructing three-dimensional structures that can be utilized as carriers for bioactive factors, drugs, and cells (Ostrovidov, Shi, et al, 2014;Tamayol, Wong, & Bahrami, 2012). Cell-loaded microfibres can simulate the hierarchical assembly of natural tissues and have been bioengineered to mimic several tissues, including cardiac, neural, muscular, and skin tissues (Jun, Kang, Chae, & Lee, 2014;Tamayol et al, 2015;Wan, Leong, Toh, et al, 2012). Thus, Onoe et al (2013) fabricated a cell-laden microfibre encapsulating primary pancreatic islet cells that was transplanted into the subrenal capsular space of diabetic mice and induced the normalization of the blood glucose concentrations post transplantation.…”

Section: Discussionmentioning

confidence: 99%

Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Ebrahimi

Ostrovidov

Salehi

et al. 2018

J Tissue Eng Regen Med

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Bioengineered functional muscle tissues are beneficial for regenerative medicine due to their treatment potential for various debilitating disorders, including myopathy and traumatic injuries. However, the contractile properties of engineered muscle constructs are lacking compared with their native counterparts. Here, we used microfluidic spinning to fabricate photocrosslinkable gelatin methacryloyl (GelMA) hydrogel fibres with well-defined surface morphologies for engineering muscle tissues. We examined whether the combination of topographical cues from surface micropatterning and biochemical stimulation with recombinant agrin can improve the generation of bioengineered muscle tissue. Topographical cues on micropatterned fibres promoted alignment of C2C12 myoblasts and augmented myotube formation during differentiation, as assessed by increased myotube length, aspect ratio, and the elevated mRNA expression of myogenic genes. Moreover, agrin treatment significantly increased acetylcholine receptor expression/clustering and myotube formation and upregulated dystrophin expression in differentiated C2C12 myotubes. Interestingly, the combination of topographical cues with agrin treatment further enhanced myotube maturation and functionality as shown by improved contractility under electrical stimulation. Thus, combining topographical cues and agrin treatment improved functions of engineered muscle tissue, which has potential in biorobotics, drug screening, tissue engineering, and regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Ebrahimi

Ostrovidov

Salehi

et al. 2018

J Tissue Eng Regen Med

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“…Sang‐Hoon Lee et al have adopted a coaxial flow microfluidic device to fabricate NaA‐CS microfibers; however, the filtering procedure, which is to remove undesired aggregated suspension of NaA and CS before spinning, makes the amount of CS component left in the NaA‐CS microfibers uncertain. Wan et al have used interfacial complexation technique to fabricate NaA/CS solid microfibers; however, the diameter of the microfibers fabricated by this method was varied from 10 to 20 μm. Large‐scale cells encapsulation and bulk production of the microfibers remain a bottleneck.…”

Section: Introductionmentioning

confidence: 99%

Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability

Liu

Wang

et al. 2019

J Biomed Mater Res

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Sodium alginate (NaA) has been widely used as microfiber‐based scaffold material. However, Ca‐alginate microfiber might disintegrate in the physiological environment due to the loss of calcium ions, which will limit its long‐term application in tissue engineering. In this work, to enhance the stability of Ca‐alginate microfiber in the physiological environment, an inner chitosan coating was introduced to Ca‐alginate hollow microfiber by one step via a microfluidic device. A more stable composite microfiber with double cross‐linking layers was generated. The stability of the microfiber was studied in the PBS solution (pH 7.4) to identify the coating effect on the hollow structure. The results revealed that chitosan component bonded an NaA layer to form a stable polyelectrolyte complex membrane in the inner wall of the microfiber, which stabilized the hollow region even though the Ca‐alginate shell was disintegrated by PBS solution. In addition, the introduction of chitosan coating improved the inner environment of the low affinity of alginate to cell surfaces and facilitated the cell adhesion and culture in the microfiber. HepG2 cells in the microfibers displayed favorable cell viability and proliferation ability. We believe that this work will lead to the development of innovative methodologies and materials for both cell culture and tissue engineering application. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2527–2536, 2019.

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“…This combination of characteristics have been recognized as beneficial for preparation of fibers for biomedical applications. [44][45][46][47] As an additional benefit, large scale high throughput IPC spinning has been demonstrated to be feasible. [48][49][50] While IPC spinning of colloidal materials such as carbon nanotubes and protein amyloids into strong fibers has been shown, [49][50][51] IPC spinning of CNF-based fibers remains yet to be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Interfacial Polyelectrolyte Complex Spinning of Cellulose Nanofibrils for Advanced Bicomponent Fibers

et al. 2017

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ABSTRACT. Fiber spinning of anionic TEMPO-oxidized cellulose (TOCN) nanofibrils with polycations by interfacial polyelectrolyte complexation is demonstrated. The formed fibers were mostly composed of cellulose nanofibrils and the polycations were a minor constituent, leading to yield and ultimate strengths of ca. 100 MPa and ca. 200 MPa, and Young's modulus of ca. 15 GPa.Stretching of the as-formed wet filaments of TOCN/polycation by 20 % increased the Young's modulus, yield strength, and ultimate tensile strength by approximately 45, 36 and 26 %, respectively. Importantly, feasibility of compartmentalized wound bicomponent fibers by simultaneous spinning of two fibers of different compositions and entwining them together was shown. This possibility was further exploited to demonstrate reversible shape change of a bicomponent fiber directly by humidity change, and indirectly by temperature changes based on thermally dependent humidity absorption.The demonstrated route for TOCN-based fiber preparation is expected to open up new avenues in the application of nanocelluloses in advanced fibrous materials, crimping, and responsive smart textiles.

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Multicomponent Fibers by Multi‐interfacial Polyelectrolyte Complexation

Cited by 55 publications

References 21 publications

Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Simple fabrication of inner chitosan‐coated alginate hollow microfiber with higher stability

Interfacial Polyelectrolyte Complex Spinning of Cellulose Nanofibrils for Advanced Bicomponent Fibers

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