Multicomponent Cross-Dehydrogenative Coupling of Imidazo[1,2-a]pyridine: Access to Abnormal Mannich and Mannich-Type Reaction
Segufa Rahaman,
Suhag Singh Sahay,
Annu Kumari
et al.
Abstract:This study showcases successfully switchable approaches to accomplish the C3-aryl methylation and C3amino methylation of privileged nitrogen-containing pharmaceutical compounds "imidazopyridines" with distinct amines, which surmounts the long-standing requirement for a superfluous directing group. These two transformations manifest pronounced regio-and chemo-divergent behavior, successfully demonstrating unprecedented multicomponent "abnormal Mannich and Mannichtype" reactions. The remarkable environmentally b… Show more
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