Multicomponent carrier-free nanodrugs for cancer treatment

Abstract

Nanocarriers can be used to deliver insoluble anticancer drugs to optimize therapeutic efficacy. However, the potential toxicity of nanocarriers cannot be ignored. Carrier-free nanodrugs are emerging safe drug delivery systems,...

Sonodynamic-chemotherapy synergy with chlorin e6-based carrier-free nanoparticles for non-small cell lung cancer

“…33 In addition, the incorporation of functional drug components typically endows carrier-free nanomedicines with a variety of therapeutic modalities, such as photodynamic therapy, sonodynamic therapy, and synergistic chemotherapy. 34 As a result, the co-assembly behavior of carrier-free nanoparticles provides an effective platform for dual-drug or multi-drug combination therapy, addressing the challenges associated with the synergistic delivery of multiple drugs in cancer treatment.…”

Application of carrier free nanomaterials in healthcare

“…This solves the problems of poor solubility and adverse side effects of chemical drugs. The materials currently used as drug carriers include polymers, dendrimers, liposomes, inorganic nanoparticles and cellular components [1]. The use of diverse nanocarrier materials is of great significance for the development of nanodrugs.…”

Advance Progress in Assembly Mechanisms of Carrier-Free Nanodrugs for Cancer Treatment

“…Commonly, carrier-free nanodrugs are fabricated via the self-assembly or coassembly of several drug active ingredients without or with little use of inert materials, in which the active ingredients are mainly drugs with different therapeutic mechanisms [15], including chemotherapeutic drugs [16], photosensitizers [17], targeting agents [18], antibodies to certain proteins [19], genes [20], and other functional biomolecules. This endows carrier-free nanodrugs with desirable advantages over nanocarrier-based DDS: (i) simple and green assembly process; (ii) integration of nano-based diagnosis and therapy; (iii) inhibition of multidrug resistance (MDR); (iv) synergistic therapeutic effects superior to multidrug combinations with equal-dose; (v) high drug loading capacity; (vi) low toxicity and good pharmacokinetics [21][22][23]. Therefore, carrier-free nanodrugs can compensate for the shortcomings of traditional nanocarriers, achieving efficient drug utilization and synergistic therapy effects.…”

“…Nowadays, many excellent published reviews have summarized the preparation methods, assembled ingredients, physicochemical properties, and external modifications [11,21,23,[34][35][36]. The self-assembly mechanisms and strategies involved in their preparation are few systematically discussed.…”