Multicomponent and Multicatalytic Reactions – A Synthetic Strategy Inspired by Nature

Abstract

Abstract:The dream of chemists to imitate the efficiency of Nature for the construction of complex molecules from simple starting materials has driven the development of new concepts in the area of catalysis. In this context, "Multicomponent and Multicatalytic Reactions" have emerged as a highly valuable synthetic tool. These reactions try to mimic the way the enzy-

Site-Divergent Delivery of Terminal Propargyls to Carbohydrates by Synergistic Catalysis

“…In recent years, synergistic catalysis-in which two distinct catalysts simultaneously activate two reaction partners-has gained increasing amount of attention. [54][55][56] Synergistic catalysis could enable reactivities that were difficult to attain with a single catalyst, as was demonstrated in transformations reported by other groups [54][55][56] and by us. 57,58 Meanwhile, with two (or more) catalysts functioning in synergy, this mode of catalysis proffers additional handles for selectivity control.…”

Light opens a new window for N-heterocyclic carbene catalysis

“…In addition, nature always inspires synthetic chemists to mimic its multienzymatic systems for constructing molecular complexity. 12 In this context, the combination of photocatalysis with other catalytic modes, 13 including NHC catalysis, has been established as an important platform for modern green synthesis. This distinct catalysis mode could generate products with remarkable selectivity, which are inaccessible through a single NHC catalyst system.…”

Multicatalytic Approach to One-Pot Stereoselective Synthesis of Secondary Benzylic Alcohols

“…Because the bulk of organic solvents is used for isolation and purification of synthetic intermediates, rather than as the medium of the actual chemical reactions, procedures that execute multiple synthetic steps in a one-pot fashion are advantageous from the efficiency standpoint. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The economy of one-pot synthesis 21 that connects stoichiometric and catalytic reactions, with or without limited intermediary work-up, proved highly beneficial for the synthesis of complex molecules, 22 including natural products and pharmaceuticals. [23][24][25] However, the development of one-pot protocols with multiple transition-metal catalyzed reactions operating in one vessel remains a challenge.…”