Multicompartment Microgel Beads for Co-Delivery of Multiple Drugs at Individual Release Rates

Lai, Wing‐Fu; Susha, Andrei S.; Rogach, Andrey L.

doi:10.1021/acsami.5b10274

Cited by 67 publications

(50 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug release sustainability in different compartments of a bead has also been demonstrated to be tuneable by manipulating the hydrogel composition to modulate the release proles of the codelivered agents. 20 In this study, we further extend the capacity of microuidic electrospray, and develop a novel yet facile method for the fabrication of compositionally homogeneous core-shell hydrogel microspheres. The size of the microspheres can be tuned by simply adjusting the ow rate, the solution concentration and the electric eld strength.…”

Section: Introductionmentioning

confidence: 98%

“…We have previously adopted the microuidic electrospray technology to successfully manipulate the microstructure of hydrogel particles to generate multicompartment microgels for co-delivery of incompatible agents. 20 With the use of lightemitting cadmium telluride (CdTe) quantum dots (QDs) and poly(ethylenimine) (PEI) as a model pair, the microgels have been shown to be able to partition different agents in separate compartments to minimize the interactions between the codelivered agents during the delivery process. The drug release sustainability in different compartments of a bead has also been demonstrated to be tuneable by manipulating the hydrogel composition to modulate the release proles of the codelivered agents.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrospray-mediated preparation of compositionally homogeneous core–shell hydrogel microspheres for sustained drug release

et al. 2017

Self Cite

View full text Add to dashboard Cite

Incorporating hydrogel particles with the core-shell architecture is a promising route to fabricate colloidal "smart gels" with tuneable properties. This study reports a facile electrospray-based method to generate compositionally homogeneous core-shell hydrogel microspheres. By manipulating different process parameters (e.g., electric field strength, flow rate, and gel-forming polymer concentration), the size of the microspheres can be tuned from microns to millimetres. Drug release studies demonstrate that coating the surface of the hydrogel microsphere with a hydrogel layer remarkably prolongs the drug release sustainability. In 3T3 and HEK293 cells, both the acute and delayed toxicity caused by the hydrogel microspheres are shown to be negligible. Together with the ease of operation of the production method, the compositionally homogeneous core-shell microspheres generated by our method may enhance the versatility and flexibility in future drug delivery.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Electrospray-mediated preparation of compositionally homogeneous core–shell hydrogel microspheres for sustained drug release

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, mushroom‐like alginate microgels with the cap loaded with AuNPs were synthesized by spatially confining the synthesis of AuNPs in the alginate microgels based on the floating of sodium alginate drops on calcium chloride solution . Furthermore, Janus alginate microgels loaded with incompatible drugs could be prepared and used in multidrug therapy . Regarding the shape transformation of smart hybrid materials, to date, a majority of hybrid microgels are able to change their morphology uniformly responding to external stimuli, like temperature, microwave, light exposure, etc ., however, it is still a challenge to achieve anisotropic shape transformation of hybrid microgels via external stimuli, with good recovery and high reproducibility.…”

Section: Introductionmentioning

confidence: 99%

“…[20] Furthermore, Janus alginate microgels loaded with incompatible drugs could be prepared and used in multidrug therapy. [21] Regarding the shape transformation of smart hybrid materials, to date, a majority of hybrid microgels are able to change their morphology uniformly responding to external stimuli, like temperature, microwave, light exposure, etc., [22] however, it is still a challenge 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 to achieve anisotropic shape transformation of hybrid microgels via external stimuli, with good recovery and high reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Controlled Shape Transformation and Loading Release of Smart Hemispherical Hybrid Microgels Triggered by ‘Inner Engines’

Zhu

Wei²,

et al. 2018

ChemistrySelect

View full text Add to dashboard Cite

The dynamic controlling and changing the shape of microgels, especially the anisotropic change, remains a challenge for the construction of advanced smart materials. To this end, the fabrication of hemispherical hybrid microgels (HHMs) with Au nanorods(AuNRs)‐based vesicles was demonstrated, with the thermo‐ and NIR light‐triggered anisotropic shape transformation and controlled release induced by ‘inner engines’. AuNRs‐based vesicles acting as ‘inner engines’ were first fabricated by the self‐assembly of thiol‐terminated block copolymers modified AuNRs, with the absorbance of NIR light (808 nm), thus generating heat in the system; second, poly(N‐isopropyl acrylamide) (pNIPAM)‐based HHMs containing AuNRs‐based vesicles were synthesized by the assistance of both microfluidics and photopolymerization. Importantly, uneven heat generated by the gradationally distributed AuNRs‐based vesicles in the hybrid microgels could cause an anisotropic shape change from hemispherical to mushroom‐like shape via external stimuli, with good reversibility and reproducibility. Based on this, the controlled release of loadings (e. g. Rhodamine B (RhB)) inside the engines of the microgels can be realized by combining NIR light irradiation and the shape transformation. Thus, HHMs with AuNRs‐vesicle‐based engines provide a novel platform for the investigation of drug release, artificial actuators, and micromotors.

show abstract

“…17,18 In contrast to macroscopic hydrogels, microgels exhibit reduced characteristic lengths and increased surface area, which provides potential for manipulation as a delivery platform. These strategies have been used to promote cellular encapsulation, 19,20 control drug release, 21,22 and have formed a platform for responsive materials. [23][24][25][26] Microgel encapsulation may hold advantage for the delivery of lentivectors, [27][28][29] but adapting these microfluidic techniques for producing lentivector-compatible microgels represents an engineering challenge.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic generation of alginate microgels for the controlled delivery of lentivectors

et al. 2016

View full text Add to dashboard Cite

Microgels fabricated through distinct microfluidic procedures encapsulate and release functioning lentivectors in a controlled manner.Please check this proof carefully. Our staff will not read it in detail after you have returned it.Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached -do not change the text within the PDF file or send a revised manuscript. Corrections at this stage should be minor and not involve extensive changes. All corrections must be sent at the same time.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.Please note that, in the typefaces we use, an italic vee looks like this: n, and a Greek nu looks like this: n.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: materialsB@rsc.orgQueries for the attention of the authors However, achieving safe, localized, and sufficient gene expression remain key challenges for effective lentivectoral therapy. Localized and efficient gene expression can be promoted by developing material systems to deliver lentivectors. Here, we address the utility of microgel encapsulation as a strategy for the controlled release of lentivectors. Three distinct routes for ionotropic gelation of alginate were incorporated into microfluidic templating to create lentivector-loaded microgels. Comparisons of the three microgels revealed marked differences in mechanical properties, crosslinking environment, and ultimately lentivector release and functional gene expression in vitro. Gelation with chelated calcium demonstrated low utility for gene delivery due to a loss of lentivector function with acidic gelation conditions. Both calcium carbonate gelation, and calcium chloride gelation, preserved lentivector function with a more sustained transduction and gene expression over 4 days observed with calcium chloride gelated microgels. The validation of these two strategies for lentivector microencapsulation may provide a platform for controlled gene delivery.

show abstract

Multicompartment Microgel Beads for Co-Delivery of Multiple Drugs at Individual Release Rates

Cited by 67 publications

References 64 publications

Electrospray-mediated preparation of compositionally homogeneous core–shell hydrogel microspheres for sustained drug release

Electrospray-mediated preparation of compositionally homogeneous core–shell hydrogel microspheres for sustained drug release

Controlled Shape Transformation and Loading Release of Smart Hemispherical Hybrid Microgels Triggered by ‘Inner Engines’

Microfluidic generation of alginate microgels for the controlled delivery of lentivectors

Contact Info

Product

Resources

About