Multicompartment Block Polymer Micelles

Moughton, Adam O.; Hillmyer, Marc A.; Lodge, Timothy P.

doi:10.1021/ma201865s

Cited by 445 publications

(429 citation statements)

References 156 publications

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“…90,107 Polypeptide-Based l-ABC Star Copolymers Another emerging polymer topology are miktoarm l-ABC star terpolymers. Lodge has demonstrated multicompatment micelle formation in aqueous media for synthetic star terpolymers, 15,[120][121][122] yet research in the area of peptide-containing l-ABC systems has been limited to bulk self-assembly properties. 103,104 In one such study, PS-PI-poly(e-tert-butyloxycarbonyl-L-Lysine) (PS-PI-PBLL) was found to self-assemble into lamellar nano-domains of amorphous PS and PI oriented perpendicular to liquid crystalline (smectic) PBLL domains (Fig.…”

Section: Feature Articlementioning

confidence: 99%

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Ray¹,

Johnson²,

Savin³

2013

J Polym Sci B Polym Phys

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Polypeptide-based amphiphilic block copolymers are an attractive class of materials given their ability to form welldefined aqueous nanoassemblies that respond to external stimulus through secondary structure transitions. This report will highlight recent literature in the area of polypeptide-based block copolymer self-assembly, with the major focus being on how the responsive nature and structural complexity of the polypeptide blocks can be incorporated into systems with complex topologies such as ABA/BAB/ABC triblock copolymers, AB 2 and A 2 B star copolymers, and miktoarm l-ABC star terpolymers. In particular, the role of interfacial curvature changes and how they result in morphology transitions will be discussed. The 'smart' assembly properties of peptides in complex block copolymer topologies can lead to enhanced responsiveness, morphological complexity, and unique morphological transitions with varying solution conditions. V C 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013, 51, 508-523 KEYWORDS: amphiphiles; biomimetic; block copolymers; selfassembly INTRODUCTION Amphiphilic block copolymers are able to self-assemble into well-defined nanostructures in aqueous solution. [1][2][3][4][5] The equilibrium morphology and aggregation number of diblock copolymer assemblies is primarily determined by the balance of three energetic factors: (1) interfacial tension, (2) corona chain crowding, and (3) core chain stretching. The balance of these three factors dictates an equilibrium curvature for the aggregate. 6-8 Typically, solution morphologies formed by amphiphilic block copolymers follow a trend of increasing interfacial curvature. As the hydrophilic fraction is increased in the copolymer, vesicles, cylindrical micelles, and spherical micelles (in the order of increasing interfacial curvature,) are the most common morphologies (Figure 1). 5,9,10 Physically, this is explained as a balance between entropic freedom of the hydrophilic coronal chains and shielding of the hydrophobic blocks from the aqueous solution; as the hydrophilic fraction increases, the chains are more able to effectively stabilize these assemblies without close-packing, and the free energy of the system is lowered when the coronal chains are provided more entropic freedom/mobility through increased curvature.

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Section: Feature Articlementioning

confidence: 99%

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Ray¹,

Johnson²,

Savin³

2013

J Polym Sci B Polym Phys

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“…Upon addition of a selective solvent for one of these blocks, core-shell nanoparticles are formed which have an insoluble core and solvated corona. 1 The solution self-assembly of BCPs has enabled the preparation of different micelles morphologies, including spherical 2,3 , vesicles 2,4 , cylinders [5][6][7] , and platelets 8,9 . These selfassembled materials are of interest for a range of applications from drug delivery [10][11][12][13] to composite reinforcement.…”

Section: Introductionmentioning

confidence: 99%

Versatile and controlled functionalization of polyferrocenylsilane‐b‐polyvinylsiloxane block copolymers using a N‐hydroxysuccinimidyl ester strategy

Boott

Lunn

Manners

2015

J. Polym. Sci. Part A: Polym. Chem.

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“…Over the past few decades, amphiphilic copolymers have attracted considerable interest owing to their unique self-assembly and phase behavior properties in solution and their numerous practical applications in surfactants, flocculating agents, drug delivery systems, and biomedical field [1][2][3]. Amphiphilic copolymers composed of hydrophilic and hydrophobic segments can form micelles with a hydrophobic compact inner core and a hydrophilic swollen outer shell in aqueous media [4,5].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Studies on Self-association of Biodegradable Pyrene-labeled Poly(L-lysine) Grafted with Poly(caprolactone)

Kimura

Fukushima

2014

J. Photopol. Sci. Technol.

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The biodegradable amphiphilic graft copolymer (PolyLysPy-PCL) containing hydrophilic pyrene end-labeled poly(L-lysine) (PolyLysPy) backbone and hydrophobic polycaprolactone (PCL) side chains was synthesized by the amide condensation of PolyLysPy and PCL. PolyLysPy was prepared from ring-opening polymerization of N-ε-benzyloxycarbonyl-L-lysine N-carboxyanhydride (Lys(Z)-NCA) initiated by 1-pyrenemethylamine and followed by removing the side-chain protective groups. PCL was prepared from the enzymatic ring-opening polymerization of ε-caprolactone by a porcine pancreas lipase. The structures and number-average molecular weights (Mn) of the graft copolymer and its precursors were confirmed and investigated by the 1 H NMR measurement. The self-assembly of the graft copolymer in water/DMSO mixture solution was examined by fluorescent signals assigned to the pyrene moiety. The increase in the grafting percent of PCL to a PolyLysPy polymer backbone can facilitate the self-assembly by the hydrophobic interaction of associated PCL grafts.

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Multicompartment Block Polymer Micelles

Cited by 445 publications

References 156 publications

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Versatile and controlled functionalization of polyferrocenylsilane‐b‐polyvinylsiloxane block copolymers using a N‐hydroxysuccinimidyl ester strategy

Fluorescence Studies on Self-association of Biodegradable Pyrene-labeled Poly(L-lysine) Grafted with Poly(caprolactone)

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