Multicommutation in flow analysis: concepts, applications and trends

Rocha, Fábio R.P.; Reis, Boaventura F.; Zagatto, Elias A.G.; Lima, José L.F.C.; Lapa, Rui A. S.; Santos, João L.M.

doi:10.1016/s0003-2670(02)00628-1

Cited by 213 publications

(70 citation statements)

References 81 publications

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“…3) for automatic flow analysis was reported by Cerda et al (1999)) to combine the multi-channel operation of FIA and the flexibility of multi-commutation flow systems (Rocha et al 2002). MSFIA was developed for the determination of total antioxidant capacity, measured as the cumulative capacity of the compounds present in the sample to scavenge free radicals, using DPPH• reaction at 517 nm.…”

Section: Developments In Dpph Methodsmentioning

confidence: 99%

Genesis and development of DPPH method of antioxidant assay

2011

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α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method offers the first approach for evaluating the antioxidant potential of a compound, an extract or other biological sources. This is the simplest method, wherein the prospective compound or extract is mixed with DPPH solution and absorbance is recorded after a defined period. However, with the advancement and sophistication in instrumental techniques, the method has undergone various modifications to suit the requirements, even though the basic approach remains same in all of them. This article presents a critical review on various developments to the DPPH method.

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Section: Developments In Dpph Methodsmentioning

confidence: 99%

Genesis and development of DPPH method of antioxidant assay

2011

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“…3 In this sense, flow systems are excellent tools for dealing with solutions in wet chemical analysis. 4 Among them, Multicommuted Flow Analysis (MCFA) can be considered an evolution of the flow injection concept towards Green Analytical Chemistry (GAC), 5 since the addition of the reagent to the sample zone occurs only in a strict amount when required in the analytical procedure. 4,6 MCFA design uses solenoid valves on binary sampling operation mode that makes its operation straightforward, very versatile, robust and enables the development of green analytical methodologies with low consumption of reagents and samples.…”

Section: Introductionmentioning

confidence: 99%

Versatility of a Multicommuted Flow System in the Spectrometric Determination of Three Analytes

Gomes

Lima

et al. 2017

Rev. Virtual Quim.

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Resumo: Neste trabalho foi desenvolvido um sistema de multicomutação em fluxo para a determinação de diclofenaco de sódio, ácido acetilsalicílico e fluoretos em injetáveis, comprimidos e águas de torneira, respectivamente. Para o diclofenaco de sódio, o método usado foi baseado em sua reação com permanganato de potássio (20 -80 mg L -1 ).Para o ácido acetilsalicílico, o método usado foi baseado na reação de Trinder após hidrólise alcalina do analito (25 -100 mg L -1 ). Para os íons fluoreto, o método usado foi o bem conhecido SPADNS (0,4 -1,6 mg L -1 ).Os resultados foram comparados com seus respectivos métodos de referência e, aplicando o teste-t emparelhado, nenhuma diferença estatisticamente significativa foi verificada entre eles ao nível de confiança de 95%. Após a otimização das variáveis do sistema analítico, ele foi capaz de analisar 80, 72 e 68 amostras h -1 contendo diclofenaco de sódio, ácido acetilsalicílico e fluoretos, respectivamente com geração de resíduos reduzida de acordo com os princípios básicos da química verde.Palavras-chave: Sistema de injeção em fluxo; multicomutação; injetáveis; comprimidos; águas de torneira. AbstractIn this work was developed a multicommuted flow system for determination of sodium diclofenac, acetylsalicylic acid and fluoride ions in ampoules, tablets and tap waters, respectively. For sodium diclofenac the method used was based on its reaction with potassium permanganate (20 -80 mg L -1 ). For acetylsali yli a id the ethod used as ased o Tri der s rea tio after alkali e hydrolysis of the analyte (25 -100 mg L -1 ). For fluoride ions the method used was the well-known SPADNS (0.4 -1.6 mg L -1 ). Results were compared with their respective reference methods and, by applying the paired t-test, no statistic difference between them was verified at the 95% confidence level. After optimization of the variables of the analytical system, it was able to analyze 80, 72 and 68 sample h -1 containing sodium diclofenac, acetylsalicylic acid and fluoride, respectively with reduced waste generation according to basic principles of green chemistry.

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“…However, FI techniques had suffered from the limitation of multi-quantification with a separation procedure. Nevertheless, some approaches were proposed for multiquantification without implying separation procedures [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Optimizing SIC assay method for acetyl salicylic acid and rosuvastatin and adapting to HPLC with performance comparison

Idris¹,

Alnajjar²

2015

Acta Chromatographica

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Summary. Acetyl salicylic acid (ASA), as the major drug consumed in the world, has been combined with other various drugs. In this regard, ASA-rosuvastatin is the most recent combination. The current article reported the first two separation methods for the assay of that combination utilizing sequential injection chromatography (SIC) and highperformance liquid chromatography (HPLC). The optimization process was conducted for SIC, and the optimum conditions were then adapted to HPLC. Both methods, SIC and HPLC, were validated and successfully applied to tablet formulation. In both methods, the analytes were chromatographed onto a short C18 monolithic column (4.6 × 25 mm) by a mobile phase composition of 10 mmol L −1 phosphate:acetonitrile: methanol (50:30:20, v/v/v at pH 3.0). The performances of both methods were compared. The remarkable advantages of the SIC method over HPLC method were the reduction in reagent consumption and instrumentation simplicity and cost-effectiveness. The total volume of mobile phase consumed is three orders of magnitude larger in HPLC than that in SIC. Other analytical features of the SIC and HPLC methods were comparable and acceptable for pharmaceutical analysis. Accordingly, the SIC method could be more suitable for routine analysis of simple matrices after examining the capability of the technique to work under industrial conditions.

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Multicommutation in flow analysis: concepts, applications and trends

Cited by 213 publications

References 81 publications

Genesis and development of DPPH method of antioxidant assay

Genesis and development of DPPH method of antioxidant assay

Versatility of a Multicommuted Flow System in the Spectrometric Determination of Three Analytes

Optimizing SIC assay method for acetyl salicylic acid and rosuvastatin and adapting to HPLC with performance comparison

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