Multicommutated generation of concentration gradients in a flow-batch system for metronidazole spectrophotometric determination in drugs

Multi-commutation in flow analysis: Recent developments and applications

“…The most often used strategy is to replace the reagent merging streams according to the aimed determinations, and the random access reagent selection [14] is beneficial in this regard. Other possibilities involve multi-site detection [46], exploitation of concentration gradients [51], sandwich techniques [23], addition of a discriminating reagent for speciation [63], flow reversals [64], stream splitting [65], etc.…”

“…obtaining the analytical curve [50], implementing the standard addition method [51] and performing spiking [52].…”

Voltammetric sensitive determination of metronidazole at poly(p-aminobenzene sulfonic acid)-modified glassy carbon electrode

“…Metronidazole has been determined in various pharmaceutical preparations, blood plasma and urine by gas chromatography mass spectrometry [3], liquid chromatography [4], high performance liquid chro matography [5][6][7], packed column supercritical fluid chromatography [8], amperometric [9], colorimetric [10], ultra performance liquid chromatography mass spectrometry [11], nuclear magnetic resonance spec troscopy [12], short wavelength near infrared spec troscopy [13], and spectrophotometry [14,15]. A few electrochemical studies have been conducted on the electrochemical behavior and determination of metronidazole in pharmaceuticals and biological sam ples by voltammetric techniques.…”

Automatic Flow-Batch System for Cold Vapor Atomic Absorption Spectroscopy Determination of Mercury in Honey from Argentina Using Online Sample Treatment

“…These systems are characterized by the use of a dilution/mixing/reaction chamber, containing a magnetic stirring bar and three-way solenoids valves fully computer-controlled. During the past decade, these systems have been used for many determinations including fluorescent determination with online extraction, titrations, , preparation of calibration solutions, screening analysis, nephelometric, turbidimetric and chemiluminescence determinations, chemometric-assisted method, extraction procedures, and online matching of pH . The developments of new methods in the context of green analytical chemistry are promising.…”