Multicolor, injectable BSA-based lanthanide luminescent hydrogels with biodegradability

Bovine Serum Albumin/Polyvinyl Alcohol Double‐Network Hydrogel Containing ϵ‐Polylysine for Antibacterial Performance

“…In this paper, TCEP was used to open the original disulfide bond of BSA to produce more sulfhydryl groups, so that new disulfide bonds could be formed among multiple BSA, thus forming the first network through cross-linking. [29,30] By adding PVA as the second network, the two are cross-linked to form BP double network hydrogel, which makes up for the deficiencies of insufficient mechanical strength, limited hydrophilicity and insufficient elasticity of the single PVA hydrogel network. On the basis of BP hydrogel preparation, BPE double network hydrogel was prepared by adding different concentrations of EPL (Figure 1).…”

“…A key research content of antibacterial hydrogels designed for wound dressing application is to study their degradability under physiological conditions [40] . Hydrogel degradation can be achieved by degradation of main chain or its crosslinking agent, and protease is one of the main substances inducing biodegradation of hydrogel, so this paper mainly uses trypsin to induce and promote the degradation of BSA main chain to achieve the degradation of hydrogel [30,41] . As shown in Figure 7, BSA hydrogels, BP hydrogels, and BPE hydrogels also degraded to varying degrees in trypsin-free PBS buffers (pH 7.4).…”