Multiclonal emergence of ciprofloxacin-resistant clinical isolates of <i>Escherichia coli</i> and <i>Kleb-siella pneumoniae</i>

Bauernfeind, A.; Abele‐Horn, Marianne; Emmerling, P; Jungwirth, R.

doi:10.1093/jac/34.6.1074

Cited by 21 publications

(15 citation statements)

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“…The susceptibility analysis detected an increased incidence of fluoroquinolone-resistant strains in the control group along with a possible crossresistance to other antibacterial agents of unrelated classes such as betalactams, as previously reported, 20 although the low number of isolates precluded statistical analysis. In the study group, bacterial isolates did not show such a resistance pattern.…”

Section: Discussionsupporting

confidence: 73%

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Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin–tazobactam

Solano

Gutiérrez

Martínez

et al. 2005

Bone Marrow Transplant

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Summary:The safety and efficacy of early bacterial prophylaxis with piperacillin-tazobactam were prospectively evaluated in 51 autologous peripheral blood stem cell transplantation (PBSCT) recipients. The results were compared with those obtained in 51 control patients receiving oral fluoroquinolones in a retrospective matched-pair control study. Overall, 76% of the study group and 98% of the control group developed at least one febrile episode during neutropenia (P ¼ 0.002). Time from neutropenia to the first febrile episode (FFE) was significantly longer in the study group than in the control group (P ¼ 0.04). Once a febrile episode appeared, the duration of fever was significantly longer in cases than in controls (median of 5 and 2 days respectively, Po0.001), and led to a more frequent use of empirical amphotericin B (AmB), not statistically significant (P ¼ 0.13). However, the total time of antibiotic administration was significantly greater in the control than in the study group (P ¼ 0.05). The duration of AmB treatment shows a trend toward a longer duration in the control than in study group (P ¼ 0.2). Overall, 86% of the Gram-positive bacteremia and 85% of the Gram-negative bacteria were susceptible to the tested antibiotics. Our study suggests that a subgroup of patients could benefit from prophylaxis with piperacillintazobactam without increasing toxicity or bacterial resistance. Bone Marrow Transplantation (2005) 36, 59-65.

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Section: Discussionsupporting

confidence: 73%

“…In spite of the low number of patients, the quinolone group presented a higher rate of quinolone resistance, as previously described. 20,21 Response to treatment and toxicity…”

Section: Patient Characteristicsmentioning

confidence: 99%

Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin–tazobactam

Solano

Gutiérrez

Martínez

et al. 2005

Bone Marrow Transplant

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“…and Pseudomonas aeruginosa, and imipenem and amikacin resistance in Acinetobacter spp. [4][5][6] However, the clinical significance of multiresistant gram-negative bacilli (MRGNB) is not clear. Our previous observations indicated that multiresistant S. maltophilia 7 and Acinetobacter spp.…”

Section: Introductionmentioning

confidence: 99%

Bacteremia due to multiresistant gram-negative bacilli in neutropenic cancer patients: a case-controlled study

Špánik

Novotný

Mateicka

et al. 1999

Journal of Infection and Chemotherapy

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“…In Taiwan the frequency of ESBL-KP has increased steadily in recent years with reports of 10 to 30% frequency among clinical isolates of K. pneumoniae (6,12,13). Quinolones are potential therapeutic options for treatment of infections caused by ESBL-KP; however, resistance to quinolones among K. pneumoniae strains has been increasingly reported (1,2,4,6,10,14) and ranges from 5 to 33% in Taiwan (6). The main quinolone resistance mechanisms include genetic mutations in DNA gyrase and/or topoisomerase IV, caused by prior usage (3,5).…”

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confidence: 99%

Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing, Fluoroquinolone-Resistant Isolates of Klebsiella pneumoniae in Taiwan

Jones

Hollis

et al. 2002

J Clin Microbiol

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Strains of extended-spectrum ␤-lactamase-producing Klebsiella pneumoniae (ESBL-KP) have emerged worldwide. Concomitant ciprofloxacin resistance with ESBL production in K. pneumoniae isolates would severely restrict treatment options. Among 39 (18.5%) of 211 ESBL-KP isolates resistant to ciprofloxacin (MIC, >4 g/ ml), 37 (95%) were high level resistant (MIC, >16 g/ml). These isolates were also cross resistant to the newer fluoroquinolones, including levofloxacin, gatifloxacin, gemifloxacin, and garenoxacin (BMS 284756). Sitafloxacin was most active against these ciprofloxacin-resistant ESBL-KP isolates with MICs for 67% of the isolates being <2 g/ml. The molecular epidemiology of these multiresistant isolates was investigated by automated ribotyping and pulsed-field gel electrophoresis (PFGE). Ribotyping identified 18 different strains among the 39 ciprofloxacin-resistant ESBL-KP isolates. The majority (67%) of these isolates were contained in six ribogroups which were further confirmed by PFGE. The distribution of the six major strains of ciprofloxacinresistant ESBL-KP within Taiwan included one (ribogroup 255.3-PFGE type E) with a nationwide distribution and several institution-specific strains. Interhospital cooperation appears necessary, with strict infection control practices coupled with restriction of fluoroquinolone and extended-spectrum ␤-lactam use to control both the major epidemic strain and the more diverse strains observed within individual institutions.

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Multiclonal emergence of ciprofloxacin-resistant clinical isolates of Escherichia coli and Kleb-siella pneumoniae

Cited by 21 publications

References 0 publications

Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin–tazobactam

Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin–tazobactam

Bacteremia due to multiresistant gram-negative bacilli in neutropenic cancer patients: a case-controlled study

Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing, Fluoroquinolone-Resistant Isolates of Klebsiella pneumoniae in Taiwan

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