Multiclass method for the quantification of 92 veterinary antimicrobial drugs in livestock excreta, wastewater, and surface water by liquid chromatography with tandem mass spectrometry

Jinfang, Gao; Cui, Yonghui; Tao, Yanfei; Huang, Lingli; Peng, Dapeng; Xie, Shuyu; Wang, Xu; Liu, Zhenli; Chen, Dongmei; Zhang, Yuan

doi:10.1002/jssc.201600531

Cited by 19 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gao et al (2016a) developed a method for measurement of several classes of veterinary antimicrobial drugs in water and in livestock feces and urine. Optimization of extraction and clean-up conditions, including adjustment of pH, solvent, and solid-phase extraction media, are presented for each class of drug.…”

Section: Methodsmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow¹,

Cassada²,

Larsen³

et al. 2017

Water Environment Research

View full text Add to dashboard Cite

A total of 79 papers published in 2016 were reviewed ranging from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, steroids, antibiotic resistance genes, cyanotoxins, and potential effects of biochar use in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Steroid Hormones, Anthelmintics, Antibiotic Fate and Occurrence, Antibiotic Resistance Genes, Cyanotoxins, and Implications of Biochar in Agricultural Environments.

show abstract

Section: Methodsmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow¹,

Cassada²,

Larsen³

et al. 2017

Water Environment Research

View full text Add to dashboard Cite

show abstract

“…Due to the highly varied physico-chemical properties of VPRs, their low concentration levels in the environment and the complexity of environmental matrices, it is difficult to develop an optimal multi-residue analysis method for a large number of compounds, especially when they belong to different therapeutic classes. There are many analytical methods dedicated to veterinary antibiotics (Gao et al, 2016;Hu et al, 2014;Tong et al, 2009;Wei et al, 2011;Xue et al, 2015;Yao et al, 2017;Zhang et al, 2014) and some dedicated to antiparasitic drugs (Krogh et al, 2008;Thompson et al, 2009;Zrnčić et al, 2014), but few include different therapeutic classes (Iglesias et al, 2012). There is therefore a need to develop specific analytical methods and the selection of the VPRs needs to be performed according to the veterinary uses on the study site (Soulier et al, 2015).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Veterinary pharmaceutical residues in water resources and tap water in an intensive husbandry area in France

Charuaud

Jardé

Jaffrézic

et al. 2019

Science of The Total Environment

View full text Add to dashboard Cite

In intensive livestock areas, veterinary pharmaceutical residues (VPRs) can occur in water resources, but also in tap water because treatment processes are not designed to remove these contaminants. The main objective of this study is to assess the occurrence of VPRs in water resources and tap waters in Brittany. As several identical compounds are used in both veterinary and human medicine, a toolbox (stanols and pharmaceuticals) is used to help determine the origin of contamination in the case of mixed-use molecules. Water resources samples were collected from 25 sites (23 surface waters and two groundwaters) used for tap water production and located in watersheds considered as sensitive due to intensive husbandry activities. Samples were also taken at 23 corresponding tap water sites. A list of 38 VPRs of interest was analyzed. In water resources, at least one VPR was quantified in 32% of the samples. 17 different VPRs were quantified, including antibiotics, antiparasitic drugs and anti-inflammatory drugs. Concentration levels ranged between 5 ng/L and 2946 ng/L. Mixeduse pharmaceuticals were quantified in twelve samples of water resources and among these samples nine had a mixed overall fecal contamination. In the context of this large-scale study, it appeared difficult to determine precisely the factors impacting the occurrence of VPRs. VPRs were quantified in 20% of the tap water samples. Twelve VPRs were quantified, including ten compounds exclusively used in veterinary medicine and two mixed-use compounds. Concentration levels are inferior to 40 ng/L for all compounds, with the exception of the antibiotic florfenicol which was quantified at 159 ng/L and 211 ng/L. The population of Brittany may therefore be exposed to these contaminants through tap water. These observations should be put into perspective with the detection frequencies per compound which are all below 10% in both water resources and tap water.

show abstract

“…Consequently, all of the parameters involved should be adequately studied. In prior studies, a mobile phase consisting of an organic solvent and a buffer solution, which was used to adjust the pH of eluents, has been reported for separation of TCAs [17][18][19][20][21][22][23]. The mobile phase with isocratic elution often consists of ACN combined with phosphoric acid [17], oxalic acid [18], formic acid [19,20], and acetic acid [21].…”

Section: Effects Of Hplc Conditionsmentioning

confidence: 99%

Selective and sensitive determination of tetracyclines by HPLC with chemiluminescence detection based on a cerium(IV)‐methoxylated cypridina luciferin analogue system

Zeng

Lai

et al. 2018

J of Separation Science

Self Cite

View full text Add to dashboard Cite

A novel approach for the simultaneous and selective analysis of chlortetracycline, doxycycline, 4-epichlortetracycline, oxytetracycline, metacycline, and tetracycline by high-performance liquid chromatography coupled with sensitive post-column chemiluminescence reaction was set up. Six tetracyclines were separated through a simple and effective isocratic procedure using a mixture of acetonitrile and 3.5 mM methanesulfonic acid. After that, intensive chemiluminescence signals were produced by the reaction between cerium(IV) and methoxylated cypridina luciferin analogues system in the presence of tetracyclines. Under the appropriate experimental conditions, the developed method was evaluated by testing of linearity, limits of detection, precision, and accuracy. The limit of detection was from 2 to 10 nM and relative standard deviation of intraday precision was below 9%. The developed high-performance liquid chromatography with chemiluminescence method has been performed for the with trace analysis of tetracycline antibiotic residues in milk samples with satisfactory results.

show abstract

Multiclass method for the quantification of 92 veterinary antimicrobial drugs in livestock excreta, wastewater, and surface water by liquid chromatography with tandem mass spectrometry

Cited by 19 publications

References 29 publications

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Veterinary pharmaceutical residues in water resources and tap water in an intensive husbandry area in France

Selective and sensitive determination of tetracyclines by HPLC with chemiluminescence detection based on a cerium(IV)‐methoxylated cypridina luciferin analogue system

Contact Info

Product

Resources

About